Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Thody, Anthony"'
Autor:
Nicolaou, Anna, Masoodi, Mojgan, Gledhill, Karl, Haylett, A.K., Thody, Anthony J., Tobin, Desmond J., Rhodes, L.E.
High personal UVR doses can be gained during leisure activities, causing intense self-resolving inflammation (sunburn) of unprotected skin. UVR activates release of membrane fatty acids and upregulates their metabolism by cyclooxygenases (COX) and li
Externí odkaz:
http://hdl.handle.net/10454/5229
Autor:
Gledhill, Karl, Rhodes, L.E., Brownrigg, M., Haylett, A.K., Masoodi, Mojgan, Thody, Anthony J., Nicolaou, Anna, Tobin, Desmond J.
Erythema occurs in human skin following excessive exposure to ultraviolet radiation (UVR), and this is in part mediated by the vasodilator prostaglandin E2 (PGE2). While keratinocytes are a major source of this pro-inflammatory eicosanoid, epidermal
Externí odkaz:
http://hdl.handle.net/10454/4579
Autor:
Masoodi, Mojgan, Nicolaou, Anna, Gledhill, Karl, Rhodes, L.E., Tobin, Desmond J., Thody, Anthony J.
This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independen
Externí odkaz:
http://hdl.handle.net/10454/4581
Autor:
Rhodes, L.E., Gledhill, Karl, Masoodi, Mojgan, Haylett, A.K., Brownrigg, M., Thody, Anthony J., Tobin, Desmond J., Nicolaou, Anna
Yes
Sunburn is a commonly occurring acute inflammatory process, with dermal vasodilatation and leukocyte infiltration as central features. Ultraviolet (UV) B-induced hydrolysis of membrane phospholipids releases polyunsaturated fatty acids and t
Sunburn is a commonly occurring acute inflammatory process, with dermal vasodilatation and leukocyte infiltration as central features. Ultraviolet (UV) B-induced hydrolysis of membrane phospholipids releases polyunsaturated fatty acids and t
Externí odkaz:
http://hdl.handle.net/10454/4586
The proopiomelanocortin (POMC)-derived peptides, ACTH and alpha-MSH, are the principal mediators of human skin pigmentation via their action at the melanocortin-1 receptor (MC-1R). Recent data have demonstrated the existence of a functionally active
Externí odkaz:
http://hdl.handle.net/10454/3456
The pro-opiomelanocortin (POMC)-derived peptides, -melanocyte-stimulating hormone, and adrenocorticotropic hormone, are important mediators of human skin pigmentation via action at the melanocortin-1 receptor. Recent data suggests that such a regulat
Externí odkaz:
http://hdl.handle.net/10454/3606
Autor:
Hoogduijn, Martin J., Cemeli, Eduardo, Ross, K., Anderson, Diana, Thody, Anthony J., Wood, John M.
Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) are produced in the skin under the influence of UV radiation. These compounds are highly reactive and can induce DNA lesions in epidermal cells. Melanin is considered to protect human ski
Externí odkaz:
http://hdl.handle.net/10454/2311
Autor:
Nicolaou, Anna, Estdale, Siân E., Tsatmali, Marina, Herrero, Daniel Pascual, Thody, Anthony J.
Prostaglandins are potent mediators of the inflam-matory response and are also involved in cancer development. In this study, we show that human melanocytes and FM55 melanoma cells express cyclooxygenase-1 and -2 (COX-1 and-2) and thus have the capa
Externí odkaz:
http://hdl.handle.net/10454/4098
Autor:
Wood, John M., Hoogduijn, Martin J., Smit, N.P., Thody, Anthony J., Van Der Laarse, A., Van Nieuwpoort, A.F.
We have examined whether melanin affects Ca2+ homeostasis in cultured normal human melanocytes. Intracellular Ca2+ concentrations ([Ca2+]i), were measured in four Caucasian and in three Negroid melanocyte cultures. Under resting conditions [Ca2+]i wa
Externí odkaz:
http://hdl.handle.net/10454/4126
Autor:
Ancans, Janis, Tobin, Desmond J., Hoogduijn, Martin J., Smit, N.P., Wakamatsu, K., Thody, Anthony J.
The skin pigment melanin is produced in melanocytes in highly specialized organelles known as melanosomes. Melanosomes are related to the organelles of the endosomal/lysosomal pathway and can have a low internal pH. In the present study we have shown
Externí odkaz:
http://hdl.handle.net/10454/3681