Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Tho V Thieu"'
1
Copper-Catalyzed Synthesis of 5-Carboxyl-4-perfluoroalkyl Triazoles
Autor: Tho V. Thieu, Jaume Balsells, Robert Panish
Publikováno v: Organic letters. 23(15)
A facile, scalable synthesis of previously inaccessible trifluoromethyl and perfluoroalkyl triazoles is disclosed. Mediated by copper, this catalytic protocol enables access to 4-perfluoroalkyl triazoles from commodity chemicals. A catalytic Cu(II) s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea2c5e210bccd1e69da3e1b30e52792
https://pubmed.ncbi.nlm.nih.gov/34286985
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4
Discovery and Process Synthesis of Novel 2,7-Pyrrolo[2,1-f][1,2,4]triazines
Autor: Daniel V. Levy, Henry J. Breslin, Joseph A. Sclafani, Bruce D. Dorsey, Gregory R. Ott, Tho V. Thieu, Roger P. Bakale, Andrew McLean
Publikováno v: Organic Letters. 13:4204-4207
The synthesis of a new kinase inhibitor template 2-anilino-7-aryl-pyrrolo[2,1-f][1,2,4]triazine is described which includes a late stage orthogonally reactive key intermediate amenable to rapid diversification as well an optimized in situ triflate di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113264902338733b336ff27c9adf2d53
https://doi.org/10.1021/ol2015237
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5
Amorphous fluoropolymers from tetrafluoroethylene and bulky vinyl esters or vinyl ethers
Autor: M.Reza Nassirpour, Edward R. Wonchoba, Tho V Thieu, Andrew Edward Feiring, Brian E. Fischel
Publikováno v: Journal of Fluorine Chemistry. 118:95-98
Copolymers of tetrafluoroethylene (TFE) with vinyl esters and vinyl ethers having adamantyl or norbornyl side chains are prepared in good yield by radical polymerizations in organic solvents. The polymers are thermally stable, soluble in standard org
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f29b9370924baf442bf6dc5f2764179d
https://doi.org/10.1016/s0022-1139(02)00205-1
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7
2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation
Autor: Karen L. Milkiewicz, Henry J. Breslin, Mark S. Albom, Ted L. Underiner, Linda Weinberg, Gregory J. Wells, Joseph G. Lisko, Kevin J. Wells-Knecht, Diane E. Gingrich, Tho V. Thieu, Zeqi Huang, Bruce D. Dorsey, Thelma S. Angeles, Jennifer L. Mason
Publikováno v: Bioorganicmedicinal chemistry letters. 21(24)
The JAK2/STAT pathway has important roles in hematopoiesis. With the discovery of the JAK2 V617F mutation and its presence in many patients with myeloproliferative neoplasms, research in the JAK2 inhibitor arena has dramatically increased. We report
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54bd80066163478b796ed8fa11f3b001
https://pubmed.ncbi.nlm.nih.gov/22041060
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8
7-fluoroindazoles as potent and selective inhibitors of factor Xa
Autor: Bruce P. Damiano, Tho V Thieu, Thomas P. Markotan, Tianbao Lu, Yu-Kai Lee, Karen L. Milkiewicz, Nisha S. Ninan, David F. McComsey, Daniel J. Parks, Mark R. Player, Bruce E. Maryanoff, Wenxi Pan, Edward C. Giardino, Marta C. Abad, Carl Crysler
Publikováno v: Journal of medicinal chemistry. 51(2)
We have developed a novel series of potent and selective factor Xa inhibitors that employ a key 7-fluoroindazolyl moiety. The 7-fluoro group on the indazole scaffold replaces the carbonyl group of an amide that is found in previously reported factor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b58da6624a5c78fdfd45cb53da201e6
https://pubmed.ncbi.nlm.nih.gov/18159923
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