Zobrazeno 1 - 4 of 4 pro vyhledávání: '"Thn Wong"'
2
Akademický článek
Usefulness of the Bristol Stool Form Chart scoring system for the laboratory processing of faecal samples in suspected Clostridioides difficile cases.
Autor: Corrigan RA; Department of Medical Microbiology, Buckinghamshire Healthcare NHS Trust, Stoke Mandeville Hospital, Aylesbury, UK; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address: Ruth.Corrigan@doctors.org.uk., Sithamparanathan K; Department of Medical Microbiology, Buckinghamshire Healthcare NHS Trust, Stoke Mandeville Hospital, Aylesbury, UK; Department of Infection Prevention and Control, Buckinghamshire Healthcare NHS Trust, Stoke Mandeville Hospital, Aylesbury, UK., Kenny C; Department of Infection Prevention and Control, Buckinghamshire Healthcare NHS Trust, Stoke Mandeville Hospital, Aylesbury, UK., Wong THN; Department of Medical Microbiology, Buckinghamshire Healthcare NHS Trust, Stoke Mandeville Hospital, Aylesbury, UK.
Publikováno v: The Journal of hospital infection [J Hosp Infect] 2020 May; Vol. 105 (1), pp. 95-97. Date of Electronic Publication: 2019 Dec 10.
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3
Akademický článek
Cross-sectional study of the prevalence, causes and management of hospital-onset diarrhoea.
Autor: Mawer D; Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds, LS9 7TF, UK. Electronic address: damian.mawer@york.nhs.uk., Byrne F; Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds, LS9 7TF, UK., Drake S; Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds, LS9 7TF, UK., Brown C; Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds, LS9 7TF, UK., Prescott A; Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds, LS9 7TF, UK., Warne B; Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Bousfield R; Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Skittrall JP; Royal Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge, CB23 3RE, UK., Ramsay I; Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Somasunderam D; Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Bevan M; Department of Infection Prevention, Royal Gwent Hospital, Newport, NP20 2UB, UK., Coslett J; Department of Infection Prevention, Royal Gwent Hospital, Newport, NP20 2UB, UK., Rao J; Department of Microbiology, Barnsley Hospital NHS Foundation Trust, Barnsley, S75 2EP, UK., Stanley P; Infection Prevention and Control, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ, UK., Kennedy A; Infection Prevention and Control, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ, UK., Dobson R; Infection Prevention and Control, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ, UK., Long S; Department of Microbiology, East Lancashire Hospitals NHS Trust, Blackburn, BB2 3HH, UK., Obisanya T; Department of Microbiology, East Lancashire Hospitals NHS Trust, Blackburn, BB2 3HH, UK., Esmailji T; Department of Microbiology, East Lancashire Hospitals NHS Trust, Blackburn, BB2 3HH, UK., Petridou C; Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester, SO22 5DG, UK., Saeed K; Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester, SO22 5DG, UK., Brechany K; Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester, SO22 5DG, UK., Davis-Blue K; Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester, SO22 5DG, UK., O'Horan H; Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester, SO22 5DG, UK., Wake B; Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester, SO22 5DG, UK., Martin J; Department of Microbiology, Harrogate and District NHS Foundation Trust, Harrogate, HG2 7SX, UK., Featherstone J; Department of Microbiology, Harrogate and District NHS Foundation Trust, Harrogate, HG2 7SX, UK., Hall C; Department of Infectious Diseases, Hull and East Yorkshire Hospitals NHS Trust, Hull, HU3 2JZ, UK., Allen J; Department of Infectious Diseases, Hull and East Yorkshire Hospitals NHS Trust, Hull, HU3 2JZ, UK., Johnson G; Department of Infectious Diseases, Hull and East Yorkshire Hospitals NHS Trust, Hull, HU3 2JZ, UK., Hornigold C; Department of Infectious Diseases, Hull and East Yorkshire Hospitals NHS Trust, Hull, HU3 2JZ, UK., Amir N; Department of Microbiology, Mid Yorkshire Hospitals NHS Trust, Wakefield, WF1 4DG, UK., Henderson K; Inverclyde Royal Hospital, Greenock, PA16 0XN, UK., McClements C; Inverclyde Royal Hospital, Greenock, PA16 0XN, UK., Liew I; Inverclyde Royal Hospital, Greenock, PA16 0XN, UK., Deshpande A; Department of Microbiology, Inverclyde Royal Hospital, Greenock, PA16 0XN, UK., Vink E; Department of Microbiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, UK., Trigg D; Department of Infection Prevention & Control, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK., Guilfoyle J; Department of Infection Prevention & Control, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK., Scarborough M; Department of Infectious Diseases, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK., Scarborough C; Nuffield Department of Medicine, University of Oxford, OX3 7FZ, UK., Wong THN; Department of Infectious Diseases, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK., Walker T; Department of Infectious Diseases, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK., Fawcett N; Department of Medicine, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK., Morris G; Department of Microbiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, S10 2JF, UK., Tomlin K; Department of Infection Prevention & Control, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, S10 2JF, UK., Grix C; Department of Infection Prevention & Control, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, S10 2JF, UK., O'Cofaigh E; Department of Medicine, Friarage Hospital, South Tees Hospital NHS Foundation Trust, Northallerton, DL6 1JG, UK., McCaffrey D; Department of Infection Prevention & Control, James Cook University Hospital, South Tees Hospital NHS Foundation Trust, Middlesborough, TS4 3BW, UK., Cooper M; Department of Microbiology, The Royal Wolverhampton NHS Trust, Wolverhampton, WV10 0QP, UK., Corbett K; Department of Infection Prevention & Control, The Royal Wolverhampton NHS Trust, Wolverhampton, WV10 0QP, UK., French K; Department of Microbiology, The Royal Wolverhampton NHS Trust, Wolverhampton, WV10 0QP, UK., Harper S; Department of Infection Prevention & Control, The Royal Wolverhampton NHS Trust, Wolverhampton, WV10 0QP, UK., Hayward C; Department of Infection Prevention & Control, The Royal Wolverhampton NHS Trust, Wolverhampton, WV10 0QP, UK., Reid M; Department of Infection Prevention & Control, The Royal Wolverhampton NHS Trust, Wolverhampton, WV10 0QP, UK., Whatley V; Corporate Support Services, The Royal Wolverhampton NHS Trust, Wolverhampton, WV10 0QP, UK., Winfield J; Department of Infection Prevention & Control, The Royal Wolverhampton NHS Trust, Wolverhampton, WV10 0QP, UK., Hoque S; Department of Microbiology, Torbay and South Devon Healthcare NHS Foundation Trust, Torquay, TQ2 7AA, UK., Kelly L; Department of Infection Prevention & Control, Torbay and South Devon Healthcare NHS Foundation Trust, Torquay, TQ2 7AA, UK., King I; Department of Infection Prevention & Control, Ulster Hospital, South Eastern Health and Social Care Trust, Belfast, BT16 1RH, UK., Bradley A; Department of Infection Prevention & Control, Ulster Hospital, South Eastern Health and Social Care Trust, Belfast, BT16 1RH, UK., McCullagh B; Pharmacy Department, Ulster Hospital, South Eastern Health and Social Care Trust, Belfast, BT16 1RH, UK., Hibberd C; Pharmacy Department, Ulster Hospital, South Eastern Health and Social Care Trust, Belfast, BT16 1RH, UK., Merron M; Department of Infection Prevention & Control, Ulster Hospital, South Eastern Health and Social Care Trust, Belfast, BT16 1RH, UK., McCabe C; Department of Infection Prevention & Control, Ulster Hospital, South Eastern Health and Social Care Trust, Belfast, BT16 1RH, UK., Horridge S; Department of Microbiology, University Hospital Coventry, University Hospitals of Coventry and Warwickshire, Warwick, CV2 2DX, UK., Taylor J; Department of Virology and Molecular Pathology, University Hospital Coventry, University Hospitals of Coventry and Warwickshire, Warwick, CV2 2DX, UK., Koo S; Department of Microbiology, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW, UK., Elsanousi F; Department of Microbiology, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW, UK., Saunders R; Department of Microbiology, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW, UK., Lim F; Department of Microbiology, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW, UK., Bond A; Department of Microbiology, York Teaching Hospital NHS Foundation Trust, York, YO31 8HE, UK., Stone S; Royal Free Campus, University College Medical School, London, NW3 2QG, UK., Milligan ID; Department of Microbiology, Royal Free Hospital, University College London Hospitals NHS Foundation Trust, London, NW3 2QG, UK., Mack DJF; Department of Microbiology, Royal Free Hospital, University College London Hospitals NHS Foundation Trust, London, NW3 2QG, UK., Nagar A; Department of Microbiology, Antrim Area Hospital, Northern Health and Social Care Trust, Bush Road, Antrim, BT41 2RL, UK., West RM; Leeds Institute of Health Sciences, University of Leeds, Leeds, LS2 9JT, UK., Wilcox MH; Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, LS2 9JT, UK., Kirby A; Leeds Institute of Medical Research, University of Leeds, Leeds, LS2 9JT, UK., Sandoe JAT; Leeds Institute of Medical Research, University of Leeds, Leeds, LS2 9JT, UK.
Publikováno v: The Journal of hospital infection [J Hosp Infect] 2019 Oct; Vol. 103 (2), pp. 200-209. Date of Electronic Publication: 2019 May 08.
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4
Akademický článek
Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Autor: Li HK; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Rombach I; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Zambellas R; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Walker AS; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., McNally MA; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Atkins BL; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Lipsky BA; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Hughes HC; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Bose D; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Kümin M; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Scarborough C; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Matthews PC; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Brent AJ; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Lomas J; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Gundle R; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Rogers M; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Taylor A; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Angus B; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Byren I; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Berendt AR; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Warren S; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Fitzgerald FE; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Mack DJF; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Hopkins S; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Folb J; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Reynolds HE; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Moore E; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Marshall J; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Jenkins N; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Moran CE; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Woodhouse AF; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Stafford S; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Seaton RA; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Vallance C; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Hemsley CJ; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Bisnauthsing K; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Sandoe JAT; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Aggarwal I; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Ellis SC; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Bunn DJ; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Sutherland RK; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Barlow G; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Cooper C; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Geue C; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., McMeekin N; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Briggs AH; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Sendi P; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Khatamzas E; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Wangrangsimakul T; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Wong THN; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Barrett LK; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Alvand A; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Old CF; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Bostock J; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Paul J; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Cooke G; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Thwaites GE; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Bejon P; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation., Scarborough M; From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation.
Publikováno v: The New England journal of medicine [N Engl J Med] 2019 Jan 31; Vol. 380 (5), pp. 425-436.
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