Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thiwanka Bandara Samarakoon"'
Publikováno v:
The Journal of Organic Chemistry
The generation of common and stereochemically rich medium-sized benzo-fused sultams via complementary pairing of heretofore-unknown (o-fluoroaryl)sulfonyl aziridine building blocks with an array of amino alcohols/amines in a modular one-pot, sequenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264ab8fa0e6f8f8086006ba592e90bc7
https://doi.org/10.1021/acs.joc.5b01429
https://doi.org/10.1021/acs.joc.5b01429
Autor:
R. John Booth, Bryan D. Smith, Daniel L. Flynn, Lance Stewart, Tristan W. Patt, Scott C. Wise, Timothy M. Caldwell, Benjamin A. Turner, Molly M. Hood, Thomas J. Rutkoski, Wei-Ping Lu, Yu Mi Ahn, Michael Kaufman, Hanumaiah Telikepalli, Michael Clare, Subha Vogeti, Patt William Chester, Thiwanka Bandara Samarakoon, Karen M. Yates, Lakshminarayana Vogeti, Cynthia B. Leary, Lawrence Chun, Carol L. Ensinger
Publikováno v:
Molecular Cancer Therapeutics. 14:2023-2034
Altiratinib (DCC-2701) was designed based on the rationale of engineering a single therapeutic agent able to address multiple hallmarks of cancer (1). Specifically, altiratinib inhibits not only mechanisms of tumor initiation and progression, but als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d9f008c69306495e16c6fdc2698a29
https://doi.org/10.1158/1535-7163.mct-14-1105
https://doi.org/10.1158/1535-7163.mct-14-1105
Autor:
Paul R. Hanson, Naeem Asad, Salim Javed, Thiwanka Bandara Samarakoon, Qin Zang, Joanna K. Loh
Publikováno v:
Organic Letters. 16:82-85
A one-pot, sequential protocol is reported that involves complementary ambiphile pairing (CAP) of a vinyl sulfonamide with a variety of unprotected amino acids via aza-Michael addition and subsequent intramolecular amidation. The method generates div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fbfc7d6bddf8ece1ecea5ad5f88e18
https://doi.org/10.1021/ol403070w
https://doi.org/10.1021/ol403070w
Autor:
Paul R. Hanson, Thiwanka Bandara Samarakoon, Pradip K. Maity, Saqib Faisal, Robert L. Sourk, Qin Zang
Publikováno v:
ACS Combinatorial Science
Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular SNAr, alkylation with silica-sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dd006a17560431a1ff35e37d973795
https://pubmed.ncbi.nlm.nih.gov/27300570
https://pubmed.ncbi.nlm.nih.gov/27300570
Publikováno v:
ChemInform. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5bbe928bf6f436aa2d9beb913bc19ee
https://doi.org/10.1002/chin.201609195
https://doi.org/10.1002/chin.201609195
Autor:
Paul R. Hanson, Alan Rolfe, Joanna K. Loh, Gerald H. Lushington, Benjamin Neuenswander, Thiwanka Bandara Samarakoon, Patrick Porubsky, Sun Young Yoon
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1293-1302 (2012)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
The efficient synthesis of an 80-member library of unique benzoxathiazocine 1,1-dioxides by a microwave-assisted, intermolecular nucleophilic aromatic substitution (SNAr) diversification pathway is reported. Eight benzofused sultam cores were generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924a107badff3574661f9d4d6f5ff7ef
https://doaj.org/article/f068f8b0072a4d89a1cd7033c4f4328e
https://doaj.org/article/f068f8b0072a4d89a1cd7033c4f4328e
Autor:
Thiwanka Bandara Samarakoon, Alan Rolfe, Michael G. Organ, Benjamin Neuenswander, Farman Ullah, Patrick Porubsky, Paul R. Hanson, Gerald H. Lushington, Saqib Faisal, Pradip K. Maity, Fatima Z. Basha
Publikováno v:
ACS Combinatorial Science. 14:268-272
A combination of MACOS scale-out and ROMP-derived oligomeric triazole phosphates (OTP(n)) have been successfully utilized for the preparation of a 106-member library of triazole containing benzothiaoxazepine-1,1-dioxides. This report demonstrates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a4ff2fbb2935ec21ab008f066fb0de
https://doi.org/10.1021/co2001839
https://doi.org/10.1021/co2001839
Publikováno v:
Organic Letters. 12:2182-2185
A formal, one-pot [4 + 4] cyclization pathway for the generation of eight-membered sultams via in situ generation of an ortho-quinone methide (o-QM) is reported. The pairing of ambiphilic synthons in a complementary fashion is examined whereby o-fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519be57ae505b1c6f24cf75d75e407ab
https://doi.org/10.1021/ol100495w
https://doi.org/10.1021/ol100495w
Publikováno v:
Organic Letters. 12:1216-1219
A formal [4+3] epoxide cascade protocol utilizing ambiphilic sulfonamides and a variety of epoxides (masked ambiphiles) has been developed for the generation of benzothiaoxazepine-1,1'-dioxides and oxathiazepine-1,1'-dioxides. This protocol combines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ecdb4f91027c5b3ff274d510e959d7
https://doi.org/10.1021/ol100035e
https://doi.org/10.1021/ol100035e
Autor:
Paul R. Hanson, Thiwanka Bandara Samarakoon, Naeem Asad, Salim Javed, Qin Zang, Joanna K. Loh
Publikováno v:
ChemInform. 45
A one-pot, sequential protocol is reported that involves complementary ambiphile pairing (CAP) of a vinyl sulfonamide with a variety of unprotected amino acids via aza-Michael addition and subsequent intramolecular amidation. The method generates div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::264e9a0a171e4db4ae84f79fb91aed6a
https://doi.org/10.1002/chin.201423193
https://doi.org/10.1002/chin.201423193