Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Thisuri N, Wanniarachchi"'
Autor:
Dake Liu, Thisuri N. Wanniarachchi, Guangde Jiang, Gustavo Seabra, Shugeng Cao, Steven D. Bruner, Yousong Ding
Publikováno v:
RSC Chemical Biology. 3:436-446
The nitroreductase of Haemophilus influenzae metabolizes clinically used nitroimidazoles, generates dimeric metabolites and anaerobically sensitizes an E. coli mutant to antibiotics. We further uncover its biochemical and structural details.
Autor:
Dake, Liu, Thisuri N, Wanniarachchi, Guangde, Jiang, Gustavo, Seabra, Shugeng, Cao, Steven D, Bruner, Yousong, Ding
Publikováno v:
RSC chemical biology. 3(4)
Nitroheterocycle antibiotics, particularly 5-nitroimidazoles, are frequently used for treating anaerobic infections. The antimicrobial activities of these drugs heavily rely on the