Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Thirumalai R Kannan"'
Autor:
Thirumalai R Kannan, Kumaraguruparan Ramasamy, Daniel Szabo, Joel B. Baseman, Lavanya Pandranki, Sowmya Balasubramanian, Alejandra Kirkpatrick
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Mycoplasma pneumoniae is the leading cause of bacterial community-acquired pneumonia among hospitalized children in the United States. It is also responsible for a spectrum of other respiratory tract disorders and extrapulmonary manifestations in chi
Autor:
Sowmya Balasubramanian, Lavanya Pandranki, Alexander B. Taylor, Kumaraguruparan Ramasamy, Joel B. Baseman, Thirumalai R Kannan, Suzanna Maupin, Peter John Hart
Publikováno v:
Cell Microbiol
Mycoplasma pneumoniae is the leading cause of bacterial community-acquired pneumonia among hospitalised children in United States and worldwide. Community-acquired respiratory distress syndrome (CARDS) toxin is a key virulence determinant of M. pneum
Autor:
Santanu Bose, Swechha M. Pokharel, Nathalie Pagé, Jesus A. Segovia, Annabelle Cesaro, Niraj K. Shil, Joan Defrêne, Su Yu Tsai, Joel B. Baseman, Philippe A. Tessier, Te Hung Chang, Thirumalai R Kannan
Publikováno v:
The Journal of Immunology. 195:4426-4437
Recognition of viral dsRNA by endosomal TLR3 activates innate immune response during virus infection. Trafficking of TLR3 to the endolysosomal compartment arising from fusion of late endosome (LE) with lysosome is required for recognition and detecti
Autor:
Joel B. Baseman, P. John Hart, Krishnan Manickam, Lavanya Pandranki, Alexander B. Taylor, Thirumalai R Kannan, Kumaraguruparan Ramasamy, Sowmya Balasubramanian
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
mBio, Vol 9, Iss 1, p e01663-17 (2018)
mBio
mBio, Vol 9, Iss 1, p e01663-17 (2018)
mBio
Mycoplasma pneumoniae is an atypical bacterium that causes respiratory illnesses in humans, including pharyngitis, tracheobronchitis, and community-acquired pneumonia (CAP). It has also been directly linked to reactive airway disease, asthma, and ext
Autor:
Lavanya Pandranki, Jacqueline J. Coalson, Te Hung Chang, Joel B. Baseman, Marianna Cagle, Thirumalai R Kannan, Santanu Bose, Jesus A. Segovia, Vicki T. Winter
Publikováno v:
Infection and Immunity. 86
Mycoplasma pneumoniae is an atypical bacterial respiratory pathogen known to cause a range of airway inflammation and lung and extrapulmonary pathologies. We recently reported that an M. pneumoniae -derived ADP-ribosylating and vacuolating toxin call
Autor:
Thirumalai R Kannan, Kumaraguruparan Ramasamy, Manickam Krishnan, Joel B. Baseman, P. John Hart, Olga N. Pakhomova, Argentina Becker
Publikováno v:
Molecular Microbiology. 93:568-581
Summary Community-acquired respiratory distress syndrome (CARDS) toxin from Mycoplasma pneumoniae is a 591-amino-acid virulence factor with ADP-ribosyltransferase (ADPRT) and vacuolating activities. It is expressed at low levels during in vitro growt
Autor:
Jacqueline J. Coalson, Molly F. R. Principe, Thirumalai R Kannan, Edward G. Brooks, Jorge Medina, Adriana Chaparro, Peter H. Dube, Vicki T. Winter, Joel B. Baseman
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 46:815-822
Mycoplasma pneumoniae causes acute and chronic lung infections in humans, leading to a variety of pulmonary and extrapulmonary sequelae. Of the airway complications of M. pneumoniae infection, M. pneumoniae-associated exacerbation of asthma and pedia
Autor:
Jacqueline J. Coalson, Janet G. Baseman, Jay I. Peters, Edward G. Brooks, Joseph D. Diaz, Marianna Cagle, Thirumalai R Kannan, Harjinder Singh, Joel B. Baseman
Publikováno v:
Chest. 140:401-407
Background The role of Mycoplasma pneumoniae (Mp) in the initiation and persistence of asthma remains elusive. Mp community-acquired respiratory distress syndrome toxin (CARDS Tx) is a unique virulence factor that induces an intense lymphocytic respo
Publikováno v:
Cellular Microbiology. 12:1821-1831
We identified Mpn133 as a Ca(2+)-dependent cytotoxic nuclease of Mycoplasma pneumoniae. Flow cytometry analysis and immunofluorescence studies revealed the binding and internalization of recombinant Mpn133 (rMpn133) in human airway A549 cells. Amino
Publikováno v:
Journal of Bacteriology. 192:4876-4884
In this study, we identified and characterized the enzymatic properties of MG_186, a calcium-dependent Mycoplasma genitalium nuclease. MG_186 displays the hallmarks of nucleases, as indicated by its amino acid sequence similarity to other nucleases.