Zobrazeno 1 - 10
of 2 217
pro vyhledávání: '"Thirumalai D"'
How long threadlike eukaryotic chromosomes fit tidily in the small volume of the nucleus without significant entanglement is just beginning to be understood, thanks to major advances in experimental techniques. Several polymer models, which reproduce
Externí odkaz:
http://arxiv.org/abs/2410.01219
The Random First Order Transition Theory (RFOT) predicts that transport proceeds by cooperative movement of particles in domains whose sizes increase as a liquid is compressed above a characteristic volume fraction, $\phi_d$. The rounded dynamical tr
Externí odkaz:
http://arxiv.org/abs/2409.19372
Autor:
Li, Xin, Huebner, Robert J., Williams, Margot L. K., Sawyer, Jessica, Peifer, Mark, Wallingford, John B., Thirumalai, D.
Cells undergo dramatic changes in morphology during embryogenesis, yet how these changes affect the formation of ordered tissues remains elusive. Here we find that the emergence of a nematic liquid crystal phase occurs in cells during gastrulation in
Externí odkaz:
http://arxiv.org/abs/2407.12124
Local stresses in a tissue, a collective property, regulate cell division and apoptosis. In turn, cell growth and division induce active stresses in the tissue. As a consequence, there is a feedback between cell growth and local stresses. However, ho
Externí odkaz:
http://arxiv.org/abs/2405.01960
Autor:
Morrison, Greg, Thirumalai, D.
We compute the free energy of confinement ${\cal{F}}$ for a wormlike chain (WLC), with persistence length $l_p$, that is confined to the surface of a cylinder of radius $R$ under an external tension $f$ using a mean field variational approach. For lo
Externí odkaz:
http://arxiv.org/abs/2308.14162
Publikováno v:
PRX Life 1, 013010 (2023)
Contact probabilities between loci, separated by arbitrary genomic distance, for a number of cell types have been reported using genome-wide chromosome conformation capture (Hi-C) experiments. How to extract the effective interaction energies between
Externí odkaz:
http://arxiv.org/abs/2304.02795
The well known phenomenon of phase separation in synthetic polymers and proteins has become a major topic in biophysics because it has been invoked as a mechanism of compartment formation in cells, without the need for membranes. Most of the coacerva
Externí odkaz:
http://arxiv.org/abs/2303.04215
Autor:
Hori, Naoto, Thirumalai, D.
Folding of ribozymes into well-defined tertiary structures usually requires divalent cations. How Mg$^{2+}$ ions direct the folding kinetics has been a long-standing unsolved problem because experiments cannot detect the positions and dynamics of ion
Externí odkaz:
http://arxiv.org/abs/2303.02787
The complex spatiotemporal flow patterns in living tissues, driven by active forces, have many of the characteristics associated with inertial turbulence even though the Reynolds number is extremely low. Analyses of experimental data from two-dimensi
Externí odkaz:
http://arxiv.org/abs/2211.14410
A recent experiment on zebrafish blastoderm morphogenesis showed that the viscosity of the non-confluent embryonic tissue grows sharply until a critical cell density, and is a constant as the density is increased further. The increase in the viscosit
Externí odkaz:
http://arxiv.org/abs/2211.14242