Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Thirukumaran Thangaraj Kanagasabapathi"'
Selective pharmacological manipulation of cortical–thalamic co-cultures in a dual-compartment device
Autor:
Sergio Martinoia, Rocco Andrea Barone, Wytse J. Wadman, Maria Franco, Michel Marcel Jose Decre, Thirukumaran Thangaraj Kanagasabapathi
Publikováno v:
Journal of Neuroscience Methods, 214(1), 1-8. Elsevier
In this study, we demonstrate capabilities to selectively manipulate dissociated co-cultures of neurons plated in dual-compartment devices. Synaptic receptor antagonists and tetrodotoxin solutions were used to selectively control and study the networ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95dbf341607b79732ac2406533f24deb
https://doi.org/10.1016/j.jneumeth.2012.12.019
https://doi.org/10.1016/j.jneumeth.2012.12.019
Publikováno v:
Journal of Micromechanics and Microengineering. 17:743-752
Analysis of chemical and biological samples requires one or more of the following sequential steps: sampling, sample transport, sample pretreatment and sample processing. As a result of miniaturization, such total analysis systems offer manifold adva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ffc81398d7eb9832e2ac1f5b80a68a3
https://doi.org/10.1088/0960-1317/17/4/011
https://doi.org/10.1088/0960-1317/17/4/011
Autor:
Thirukumaran Thangaraj Kanagasabapathi, Manuela Marcoli, Chiara Cervetto, Sergio Martinoia, Mariateresa Tedesco, Paolo Massobrio, Przemyslaw Nowak
Publikováno v:
2013 6th International IEEE/EMBS Conference on Neural Engineering (NER).
We present a dual-chamber co-culturing device that permits investigations on network electrophysiology and functional connectivity. In this work, we characterized the dynamics and functional connectivity of interconnected homogeneous and heterogeneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8294b7633cdf4c7bd59a96a82208232
https://doi.org/10.1109/ner.2013.6696085
https://doi.org/10.1109/ner.2013.6696085
Autor:
Sergio Martinoia, Michel Marcel Jose Decre, Wytse J. Wadman, Paolo Massobrio, Mariateresa Tedesco, Thirukumaran Thangaraj Kanagasabapathi
Publikováno v:
EMBC
In this paper, we propose an experimental approach to develop an in vitro dissociated cortical-thalamic co-culture model using a dual compartment neurofluidic device. The device has two compartments separated by 10 μm wide and 3 μm high microchanne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c050da2b249cd11ca80df915b8b84c3
https://doi.org/10.1109/iembs.2011.6090144
https://doi.org/10.1109/iembs.2011.6090144
Autor:
Thirukumaran Thangaraj Kanagasabapathi, Michel Marcel Jose Decre, Davide Ciliberti, Wytse J. Wadman, Sergio Martinoia
Publikováno v:
Frontiers in Neuroengineering
Frontiers in Neuroengineering, 4. Frontiers Media S.A.
Frontiers in Neuroengineering, 4. Frontiers Media S.A.
We developed a dual compartment neurofluidic system with inter-connecting microchannels to connect neurons from their respective compartments, placed on a planar microelectrode array (MEA).The design and development of the compartmented microfluidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6c12bfc5e1998893ed66f75a060aa4
http://hdl.handle.net/11567/276325
http://hdl.handle.net/11567/276325
Autor:
Michel Marcel Jose Decre, Ke Wang, Ger J A Ramakers, Thirukumaran Thangaraj Kanagasabapathi, Marco Mellace
Publikováno v:
IEEE Engineering in Medicine and Biology Magazine, 1, 1655-1658. Institute of Electrical and Electronics Engineers (IEEE)
EMBC 2009: proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society : "engineering the future of biomedicine" : 2-6 September, 2009, Hilton Minneapolis, Minnesota, 1655-1658
STARTPAGE=1655;ENDPAGE=1658;TITLE=EMBC 2009
EMBC 2009: proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society : "engineering the future of biomedicine" : 2-6 September, 2009, Hilton Minneapolis, Minnesota, 1655-1658
STARTPAGE=1655;ENDPAGE=1658;TITLE=EMBC 2009
This work investigates an approach to record electrophysiological measurements of neuronal cell cultures in a dual compartment neurofluidic system. The two compartments are separated by 10-microm-wide and 3-microm-high microchannels and this provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c2f7d841573378838b2c724ae180dc
https://doi.org/10.1109/iembs.2009.5333892
https://doi.org/10.1109/iembs.2009.5333892
Autor:
Rocco Andrea Barone, Thirukumaran Thangaraj Kanagasabapathi, Mariateresa Tedesco, Michel Marcel Jose Decre, Wytse J. Wadman, Paolo Massobrio, Sergio Martinoia
Publikováno v:
Journal of Neural Engineering, 9(3):036010. IOP Publishing Ltd.
Co-cultures containing dissociated cortical and thalamic cells may provide a unique model for understanding the pathophysiology in the respective neuronal sub-circuitry. In addition, developing an in vitro dissociated co-culture model offers the poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7b72f95544b2ff1f54cac6ac5c41a1
https://doi.org/10.1088/1741-2560/9/3/036010
https://doi.org/10.1088/1741-2560/9/3/036010