Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Thirakorn Mokkawes"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8567 (2024)
During gliotoxin biosynthesis in fungi, the cytochrome P450 GliF enzyme catalyzes an unusual C–N ring-closure step while also an aromatic ring is hydroxylated in the same reaction cycle, which may have relevance to drug synthesis reactions in biote
Externí odkaz:
https://doaj.org/article/56721565c8ee4b70a577335f487a94e5
Publikováno v:
Molecules, Vol 28, Iss 19, p 6961 (2023)
Cytochrome P450 enzymes in the human body play a pivotal role in both the biosynthesis and the degradation of the hormone melatonin. Melatonin plays a key role in circadian rhythms in the body, but its concentration is also linked to mood fluctuation
Externí odkaz:
https://doaj.org/article/53dd9f927887425ebdf52f98ffc7ee4f
Autor:
Thirakorn Mokkawes, Sam P. de Visser
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3651 (2023)
Cytochrome P450 enzymes are versatile enzymes found in most biosystems that catalyze mono-oxygenation reactions as a means of biosynthesis and biodegradation steps. In the liver, they metabolize xenobiotics, but there are a range of isozymes with dif
Externí odkaz:
https://doaj.org/article/7b8d200db3714f0ea0b35f785235f989
Autor:
Artur Hermano Sampaio Dias, Rolly Yadav, Thirakorn Mokkawes, Asheesh Kumar, Munir S. Skaf, Chivukula V. Sastri, Devesh Kumar, Sam P. de Visser
Publikováno v:
Inorganic Chemistry. 62:2244-2256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb8777195b0071ef1afe294dc27c0b8
https://doi.org/10.1021/acs.inorgchem.2c03984
https://doi.org/10.1021/acs.inorgchem.2c03984
Autor:
Thirakorn Mokkawes, Sam P. de Visser
Publikováno v:
Mokkawes, T & De Visser, S 2023, ' Caffeine biodegradation by cytochrome P450 1A2. What determines the product distributions? ', Chemistry: A European Journal . https://doi.org/10.1002/chem.202203875
Caffeine is a natural compound found in plant seeds that after consumption by humans effects the central nervous system as well as the cardiovascular system. In general, the cytochrome P450 enzymes in the liver are involved in the biodegradation of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2497513f76ce29bb6a7998688f1397
https://research.manchester.ac.uk/en/publications/81d7eb36-2a26-490e-9dd4-4739fa702314
https://research.manchester.ac.uk/en/publications/81d7eb36-2a26-490e-9dd4-4739fa702314
Autor:
C.-C. George Yeh, Sidra Ghafoor, Jagnyesh Kumar Satpathy, Thirakorn Mokkawes, Chivukula V. Sastri, Sam P. de Visser
Publikováno v:
ACS Catalysis. 12:3923-3937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb1ee49279ddfd306fc8a2992d8b082
https://doi.org/10.1021/acscatal.1c04029
https://doi.org/10.1021/acscatal.1c04029
Publikováno v:
The journal of physical chemistry. B. 126(46)
Melatonin, a widely applied cosmetic active ingredient, has a variety of uses as a skin protector through antioxidant and anti-inflammatory functions as well as giving the body UV-induced defenses and immune system support. In the body, melatonin is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decdd35d7cd02aec9dc7722530811a2f
https://pubmed.ncbi.nlm.nih.gov/36380557
https://pubmed.ncbi.nlm.nih.gov/36380557
Publikováno v:
Wong, H, Mokkawes, T & De Visser, S 2022, ' Can the isonitrile biosynthesis enzyme ScoE assist with the biosynthesis of isonitrile groups in drug molecules? A computational study ', Physical Chemistry Chemical Physics . https://doi.org/10.1039/D2CP03409C
Many drug molecules contain isonitrile substituents; however, synthesizing these compounds remains challenging in organic chemistry. The isonitrile synthesizing enzyme ScoE utilizes a substrate with the γ-Gly substituent, and using two molecules of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b002586b4a7d0f7f3a72fa48a3f5cbc4
http://pubs.rsc.org/en/Content/ArticleLanding/2022/CP/D2CP03409C
http://pubs.rsc.org/en/Content/ArticleLanding/2022/CP/D2CP03409C
Autor:
Chieh‐Chih George Yeh, Thirakorn Mokkawes, Justin M. Bradley, Nick E. Le Brun, Sam P. de Visser
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(13)
Ferritins are ubiquitous diiron enzymes involved in iron(II) detoxification and oxidative stress responses and can act as metabolic iron stores. The overall reaction mechanisms of ferritin enzymes are still unclear, particularly concerning the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b4f7cf3901a968f9b10c1e6e284010
https://pubmed.ncbi.nlm.nih.gov/35510795
https://pubmed.ncbi.nlm.nih.gov/35510795