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Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin

Autor: Ashley J. Winter, Matthew T. Rowe, Angus N. M. Weir, Nahida Akter, Sbusisiwe Z. Mbatha, Paul D. Walker, Christopher Williams, Zhongshu Song, Paul R. Race, Christine L. Willis, Matthew P. Crump

Publikováno v: Winter, A J, Rowe, M T, Weir, A N M, Akter, N, Mbatha, S Z, Walker, P D, Williams, C, Song, Z, Race, P R, Willis, C L & Crump, M P 2022, ' Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin ', Angewandte Chemie-International Edition, vol. 61, no. 50, e202212393 . https://doi.org/10.1002/anie.202212393

Mupirocin is a clinically important antibiotic produced by Pseudomonas fluorescens NCIMB 10586 that is assembled by a complex trans-AT polyketide synthase. The polyketide fragment, monic acid, is esterified by a 9-hydroxynonanoic acid (9HN) side chai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f3287f7bbdf8f76bb39e10e426174f
https://pubmed.ncbi.nlm.nih.gov/36227272

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A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis

Autor: Nahida Akter, Matthew T. Rowe, Ashley J. Winter, Christine L. Willis, Christopher Williams, Matthew P. Crump, Thomas J. Simpson, Paul R. Race, Zhongshu Song, Angus N M Weir, Luoyi Wang, Paul D. Walker

Publikováno v: Walker, P D, Rowe, M T, Winter, A J, Weir, A N M, Akter, N, Wang, L, Race, P R, Williams, C, Song, Z, Simpson, T J, Willis, C L & Crump, M P 2020, ' A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis ', ACS Chemical Biology, vol. 2020 . https://doi.org/10.1021/acschembio.9b00969

Mupirocin, a commercially available antibiotic produced by Pseudomonas fluorescens NCIMB 10586, and thiomarinol, isolated from the marine bacterium Pseudoalteromonas sp. SANK 73390, both consist of a polyketide-derived monic acid homologue esterified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea14d9c93247b430f0a870296365c246
https://doi.org/10.1021/acschembio.9b00969

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Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans-AT Polyketide Synthase Pathway

Autor: Joanne Hothersall, Zhongshu Song, Jack A. Connolly, Thomas J. Simpson, Peter J. Winn, Hadi H. Mohammad, Paul R. Race, Christine L. Willis, Christopher M. Thomas

Publikováno v: Mohammad, H H, Connolly, J A, Song, Z, Hothersall, J, Race, P R, Willis, C L, Simpson, T J, Winn, P J & Thomas, C M 2018, ' Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans-AT Polyketide Synthase Pathway ', ChemBioChem, vol. 19, no. 8, pp. 836-841 . https://doi.org/10.1002/cbic.201800036

The addition or removal of hydroxy groups modulates the activity of many pharmacologically active biomolecules. It can be integral to the basic biosynthetic factory or result from associated tailoring steps. For the anti-MRSA antibiotic mupirocin, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d2026ceac28f9acda4ee2da1cf8ce8
http://www.scopus.com/inward/record.url?scp=85043569007&partnerID=8YFLogxK

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