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Co-crystals of thiobarbituric acid and N-heterocyclic compounds: Synthesis, structural, solubility, computational, and antilymphoma activity

Autor: Nidhi Goel, Hem Lata, Dhananjay S. Raghubanshi, Shiv Govind Rawat, Ajay Kumar, Naresh Kumar

Publikováno v: Next Materials, Vol 7, Iss , Pp 100375- (2025)

Two new co-crystals (1–2) were prepared by the reaction of 2-thiobarbituric acid with N-heterocyclic compounds, and successfully characterized. X-ray analysis shows that 1 and 2 have zig-zag and ladder like supramolecular frameworks, respectively.

Externí odkaz: https://doaj.org/article/53f68dfef64846039f04b050cdbafc70

Synthesis, molecular docking and DFT analysis of novel bis-Schiff base derivatives with thiobarbituric acid for α-glucosidase inhibition assessment

Autor: Saba Gul, Faheem Jan, Aftab Alam, Abdul Shakoor, Ajmal Khan, Abdullah F. AlAsmari, Fawaz Alasmari, Momin Khan, Li Bo

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract A library of novel bis-Schiff base derivatives based on thiobarbituric acid has been effectively synthesized by multi-step reactions as part of our ongoing pursuit of novel anti-diabetic agents. All these derivatives were subjected to in vit

Externí odkaz: https://doaj.org/article/6dfcc8e297ff4cb8a10743f50bab1570

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New formyl indole derivatives based on thiobarbituric acid and their nano-formulations; synthesis, characterization, parasitology and histopathology investigations.

Autor: Abdelhalim WA; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt., Rabee AR; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt. ahmedrabee@alexu.edu.eg., Soliman SM; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt. Saeed.soliman@alexu.edu.eg., Hagar M; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt. mohamed.hagar@alexu.edu.eg., Moneer EA; Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, 21500, Egypt., Bakr BA; Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt., Barakat A; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia., Haukka M; Department of Chemistry, University of Jyväskylä, P.O. Box 35, Jyväskylä, FI-40014, Finland., Rasheed HA; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt.

Publikováno v: Scientific reports [Sci Rep] 2025 Jan 02; Vol. 15 (1), pp. 299. Date of Electronic Publication: 2025 Jan 02.