Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Autor: Teumer, Alexander, Li, Yong, Ghasemi, Sahar, Prins, Bram P, Wuttke, Matthias, Hermle, Tobias, Giri, Ayush, Sieber, Karsten B, Qiu, Chengxiang, Kirsten, Holger, Tin, Adrienne, Chu, Audrey Y, Bansal, Nisha, Feitosa, Mary F, Wang, Lihua, Chai, Jin-Fang, Cocca, Massimiliano, Fuchsberger, Christian, Gorski, Mathias, Hoppmann, Anselm, Horn, Katrin, Li, Man, Marten, Jonathan, Noce, Damia, Nutile, Teresa, Sedaghat, Sanaz, Sveinbjornsson, Gardar, Tayo, Bamidele O, Van Der Most, Peter J, Xu, Yizhe, Yu, Zhi, Gerstner, Lea, Ärnlöv, Johan, Bakker, Stephan JL, Baptista, Daniela, Biggs, Mary L, Boerwinkle, Eric, Brenner, Hermann, Burkhardt, Ralph, Carroll, Robert J, Chee, Miao-Li, Chee, Miao-Ling, Chen, Mengmeng, Cheng, Ching-Yu, Cook, James P, Coresh, Josef, Corre, Tanguy, Danesh, John, De Borst, Martin H, De Grandi, Alessandro, De Mutsert, Renée, De Vries, Aiko PJ, Degenhardt, Frauke, Dittrich, Katalin, Divers, Jasmin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Felix, Janine F, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Gansevoort, Ron T, Giedraitis, Vilmantas, Gögele, Martin, Grundner-Culemann, Franziska, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hamet, Pavel, Harris, Tamara B, Hicks, Andrew A, Holm, Hilma, Foo, Valencia Hui Xian, Hwang, Shih-Jen, Ikram, M Arfan, Ingelsson, Erik, Jaddoe, Vincent WV, Jakobsdottir, Johanna, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Khor, Chiea-Chuen, Kiess, Wieland, Koenig, Wolfgang, Körner, Antje, Kovacs, Peter, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jianjun, Loeffler, Markus, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Maranville, Joseph C, Mascalzoni, Deborah, McMullen, Barbara, Meisinger, Christa, Meitinger, Thomas, Miliku, Kozeta, Mook-Kanamori, Dennis O, Müller-Nurasyid, Martina, Mychaleckyj, Josyf C, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Noordam, Raymond, Connell, Jeffrey O', Olafsson, Isleifur, Palmer, Nicholette D, Peters, Annette, Podgornaia, Anna I, Ponte, Belen, Poulain, Tanja, Pramstaller, Peter P, Rabelink, Ton J, Raffield, Laura M, Reilly, Dermot F, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rivadeneira, Fernando, Runz, Heiko, Ryan, Kathleen A, Sabanayagam, Charumathi, Saum, Kai-Uwe, Schöttker, Ben, Shaffer, Christian M, Shi, Yuan, Smith, Albert V, Strauch, Konstantin, Stumvoll, Michael, Sun, Benjamin B, Szymczak, Silke, Tai, E-Shyong, Tan, Nicholas YQ, Taylor, Kent D, Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris HL, Thomsen, Hauke, Thorsteinsdottir, Unnur, Tönjes, Anke, Tremblay, Johanne, Uitterlinden, André G, Van Der Harst, Pim, Verweij, Niek, Vogelezang, Suzanne, Völker, Uwe, Waldenberger, Melanie, Wang, Chaolong, Wilson, Otis D, Wong, Charlene, Wong, Tien-Yin, Yang, Qiong, Yasuda, Masayuki, Akilesh, Shreeram, Bochud, Murielle, Böger, Carsten A, Devuyst, Olivier, Edwards, Todd L, Ho, Kevin, Morris, Andrew P, Parsa, Afshin, Pendergrass, Sarah A, Psaty, Bruce M, Rotter, Jerome I, Stefansson, Kari, Wilson, James G, Susztak, Katalin, Snieder, Harold, Heid, Iris M, Scholz, Markus, Butterworth, Adam S, Hung, Adriana M, Pattaro, Cristian, Köttgen, Anna

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,

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Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Autor: Tobias Hermle, Holger Kirsten, Karsten B. Sieber, Aiko P. J. de Vries, Su Chi Lim, Peter Kovacs, Charumathi Sabanayagam, Carl D. Langefeld, Bernhard K. Krämer, Kent D. Taylor, Janine F. Felix, Belen Ponte, Markus Loeffler, Mary F. Feitosa, Kai-Uwe Eckardt, Jianjun Liu, Katalin Dittrich, Charlene A. Wong, Uwe Völker, Adriana M. Hung, Thomas Meitinger, Anubha Mahajan, Anselm Hoppmann, Erik Ingelsson, Martin H. de Borst, Oscar H. Franco, Niek Verweij, Kai-Uwe Saum, Vilmundur Gudnason, Bram P. Prins, Carsten A. Böger, Terho Lehtimäki, Andrew A. Hicks, Todd L. Edwards, Olivier Devuyst, Peter P. Pramstaller, Katrin Horn, Leslie A. Lange, Johanne Tremblay, Jin-Fang Chai, Sahar Ghasemi, Kjell Nikus, Tanja Poulain, Massimiliano Cocca, Anna Köttgen, Eric Boerwinkle, Barry I. Freedman, Miao-Ling Chee, Man Li, Stephan J. L. Bakker, Tamara B. Harris, Albert V. Smith, Ton J. Rabelink, Dennis O. Mook-Kanamori, Iris M. Heid, Jasmin Divers, Chaolong Wang, Kathleen A. Ryan, Pavel Hamet, Silke Szymczak, Shih-Jen Hwang, Hauke Thomsen, Rainer Rettig, Ayush Giri, Fernando Rivadeneira, Leo-Pekka Lyytikäinen, Cristian Pattaro, Andrej Teren, Valencia Hui Xian Foo, Myriam Rheinberger, Audrey Y. Chu, Barbara McMullen, Franziska Grundner-Culemann, Masayuki Yasuda, Murielle Bochud, Martin Gögele, Anke Tönjes, Jeannette Lee, Adrienne Tin, Kevin Ho, Konstantin Strauch, Josef Coresh, Renée de Mutsert, Sandra Freitag-Wolf, Gardar Sveinbjornsson, Yizhe Xu, Katalin Susztak, Tien Yin Wong, Mary L. Biggs, Isleifur Olafsson, Qiong Yang, Antje Körner, Chengxiang Qiu, E-Shyong Tai, Martina Müller-Nurasyid, Ben Schöttker, Jeffrey O' Connell, Mengmeng Chen, Daniel F. Gudbjartsson, Dermot F. Reilly, Vincent W. V. Jaddoe, Damia Noce, Pim van der Harst, Sanaz Sedaghat, Chiea Chuen Khor, Adam S. Butterworth, Mathias Gorski, Robert J. Carroll, James G. Wilson, Johan Ärnlöv, Christa Meisinger, Kenneth Rice, Bettina Jung, Christian M. Shaffer, Unnur Thorsteinsdottir, Matthias Nauck, Shreeram Akilesh, Mika Kähönen, Johanna Jakobsdottir, Melanie Waldenberger, Ralph Burkhardt, Daniela Baptista, John Danesh, Benjamin B. Sun, Karlhans Endlich, Holly Kramer, Frauke Degenhardt, Wolfgang Lieb, Kari Stefansson, Joachim Thiery, Lars Lind, Nicholette D. Palmer, Sarah A. Pendergrass, Suzanne Vogelezang, Peter J. van der Most, Afshin Parsa, Markus Scholz, Florian Kronenberg, Joseph C. Maranville, Laura M. Raffield, Hermann Brenner, Wieland Kiess, Anna I. Podgornaia, Yuan Shi, Tanguy Corre, Miao-Li Chee, Deborah Mascalzoni, Bamidele O. Tayo, Navya Shilpa Josyula, Ching-Yu Cheng, Lea Gerstner, Nisha Bansal, Jerome I. Rotter, Alexander Teumer, Vilmantas Giedraitis, Raymond Noordam, Ron T. Gansevoort, Lihua Wang, Andrew P. Morris, Bruce M. Psaty, Boting Ning, Zhi Yu, Christian Fuchsberger, Matthias Wuttke, Heiko Runz, Annette Peters, Yih Chung Tham, James P. Cook, Yong Li, Chris H. L. Thio, Hilma Holm, Alessandro De Grandi, Jonathan Marten, André G. Uitterlinden, Andre Franke, Nicholas Y. Q. Tan, Otis D. Wilson, Georg Ehret, Cecilia M. Lindgren, Josyf C. Mychaleckyj, Wolfgang Koenig, Harold Snieder, Michael Stumvoll, Kozeta Miliku, M. Arfan Ikram, Teresa Nutile

Publikováno v: Nature Communications
Nature Communications, 10. NATURE PUBLISHING GROUP
Nature Communications, 10(1):4130. Nature Publishing Group
Nature Communications, 10:4130. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications, Vol. 10, No 1 (2019) P. 4130
NATURE COMMUNICATIONS
Nat. Commun. 10:4130 (2019)
Teumer, A, Li, Y, Ghasemi, S, Prins, B P, Wuttke, M, Hermle, T, Giri, A, Sieber, K B, Qiu, C, Kirsten, H, Tin, A, Chu, A Y, Bansal, N, Feitosa, M F, Wang, L, Chai, J-F, Cocca, M, Fuchsberger, C, Gorski, M, Hoppmann, A, Horn, K, Li, M, Marten, J, Noce, D, Nutile, T, Sedaghat, S, Sveinbjornsson, G, Tayo, B O, van der Most, P J, Xu, Y, Yu, Z, Gerstner, L, Ärnlöv, J, Bakker, S J L, Baptista, D, Biggs, M L, Boerwinkle, E, Brenner, H, Burkhardt, R, Carroll, R J, Chee, M-L, Chee, M-L, Chen, M, Cheng, C-Y, Cook, J P, Coresh, J, Corre, T, Danesh, J, de Borst, M H, De Grandi, A, de Mutsert, R, de Vries, A P J, Degenhardt, F, Dittrich, K, Divers, J, Eckardt, K-U, Ehret, G, Endlich, K, Felix, J F, Franco, O H, Franke, A, Freedman, B I, Freitag-Wolf, S, Gansevoort, R T, Giedraitis, V, Gögele, M, Grundner-Culemann, F, Gudbjartsson, D F, Gudnason, V, Hamet, P, Harris, T B, Hicks, A A, Holm, H, Foo, V H X, Hwang, S-J, Ikram, M A, Ingelsson, E, Jaddoe, V W V, Jakobsdottir, J, Josyula, N S, Jung, B, Kähönen, M, Khor, C-C, Kiess, W, Koenig, W, Körner, A, Kovacs, P, Kramer, H, Krämer, B K, Kronenberg, F, Lange, L A, Langefeld, C D, Lee, J J-M, Lehtimäki, T, Lieb, W, Lim, S-C, Lind, L, Lindgren, C M, Liu, J, Loeffler, M, Lyytikäinen, L-P, Mahajan, A, Maranville, J C, Mascalzoni, D, McMullen, B, Meisinger, C, Meitinger, T, Miliku, K, Mook-Kanamori, D O, Müller-Nurasyid, M, Mychaleckyj, J C, Nauck, M, Nikus, K, Ning, B, Noordam, R, Connell, J O, Olafsson, I, Palmer, N D, Peters, A, Podgornaia, A I, Ponte, B, Poulain, T, Pramstaller, P P, Rabelink, T J, Raffield, L M, Reilly, D F, Rettig, R, Rheinberger, M, Rice, K M, Rivadeneira, F, Runz, H, Ryan, K A, Sabanayagam, C, Saum, K-U, Schöttker, B, Shaffer, C M, Shi, Y, Smith, A V, Strauch, K, Stumvoll, M, Sun, B B, Szymczak, S, Tai, E-S, Tan, N Y Q, Taylor, K D, Teren, A, Tham, Y-C, Thiery, J, Thio, C H L, Thomsen, H, Thorsteinsdottir, U, Tönjes, A, Tremblay, J, Uitterlinden, A G, van der Harst, P, Verweij, N, Vogelezang, S, Völker, U, Waldenberger, M, Wang, C, Wilson, O D, Wong, C, Wong, T-Y, Yang, Q, Yasuda, M, Akilesh, S, Bochud, M, Böger, C A, Devuyst, O, Edwards, T L, Ho, K, Morris, A P, Parsa, A, Pendergrass, S A, Psaty, B M, Rotter, J I, Stefansson, K, Wilson, J G, Susztak, K, Snieder, H, Heid, I M, Scholz, M, Butterworth, A S, Hung, A M, Pattaro, C & Köttgen, A 2019, ' Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria ', Nature Communications, vol. 10, no. 1, pp. 4130 . https://doi.org/10.1038/s41467-019-11576-0
Teumer, Alexander; Li, Yong; Ghasemi, Sahar; Prins, Bram P; Wuttke, Matthias; Hermle, Tobias; Giri, Ayush; Sieber, Karsten B; Qiu, Chengxiang; Kirsten, Holger; Tin, Adrienne; Chu, Audrey Y; Bansal, Nisha; Feitosa, Mary F; Wang, Lihua; Chai, Jin-Fang; Cocca, Massimiliano; Fuchsberger, Christian; Gorski, Mathias; Hoppmann, Anselm; ... (2019). Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Nature communications, 10(1), p. 4130. Nature Publishing Group 10.1038/s41467-019-11576-0
Nature communications 10 (2019). doi:10.1038/s41467-019-11576-0
info:cnr-pdr/source/autori:Teumer A.; Li Y.; Ghasemi S.; Prins B.P.; Wuttke M.; Hermle T.; Giri A.; Sieber K.B.; Qiu C.; Kirsten H.; Tin A.; Chu A.Y.; Bansal N.; Feitosa M.F.; Wang L.; Chai J.-F.; Cocca M.; Fuchsberger C.; Gorski M.; Hoppmann A.; Horn K.; Li M.; Marten J.; Noce D.; Nutile T.; Sedaghat S.; Sveinbjornsson G.; Tayo B.O.; van der Most P.J.; Xu Y.; Yu Z.; Gerstner L.; Arnlov J.; Bakker S.J.L.; Baptista D.; Biggs M.L.; Boerwinkle E.; Brenner H.; Burkhardt R.; Carroll R.J.; Chee M.-L.; Chee M.-L.; Chen M.; Cheng C.-Y.; Cook J.P.; Coresh J.; Corre T.; Danesh J.; de Borst M.H.; De Grandi A.; de Mutsert R.; de Vries A.P.J.; Degenhardt F.; Dittrich K.; Divers J.; Eckardt K.-U.; Ehret G.; Endlich K.; Felix J.F.; Franco O.H.; Franke A.; Freedman B.I.; Freitag-Wolf S.; Gansevoort R.T.; Giedraitis V.; Gogele M.; Grundner-Culemann F.; Gudbjartsson D.F.; Gudnason V.; Hamet P.; Harris T.B.; Hicks A.A.; Holm H.; Foo V.H.X.; Hwang S.-J.; Ikram M.A.; Ingelsson E.; Jaddoe V.W.V.; Jakobsdottir J.; Josyula N.S.; Jung B.; Kahonen M.; Khor C.-C.; Kiess W.; Koenig W.; Korner A.; Kovacs P.; Kramer H.; Kramer B.K.; Kronenberg F.; Lange L.A.; Langefeld C.D.; Lee J.J.-M.; Lehtimaki T.; Lieb W.; Lim S.-C.; Lind L.; Lindgren C.M.; Liu J.; Loeffler M.; Lyytikainen L.-P.; Mahajan A.; Maranville J.C.; Mascalzoni D.; McMullen B.; Meisinger C.; Meitinger T.; Miliku K.; Mook-Kanamori D.O.; Muller-Nurasyid M.; Mychaleckyj J.C.; Nauck M.; Nikus K.; Ning B.; Noordam R.; Connell J.O.; Olafsson I.; Palmer N.D.; Peters A.; Podgornaia A.I.; Ponte B.; Poulain T.; Pramstaller P.P.; Rabelink T.J.; Raffield L.M.; Reilly D.F.; Rettig R.; Rheinberger M.; Rice K.M.; Rivadeneira F.; Runz H.; Ryan K.A.; Sabanayagam C.; Saum K.-U.; Schottker B.; Shaffer C.M.; Shi Y.; Smith A.V.; Strauch K.; Stumvoll M.; Sun B.B.; Szymczak S.; Tai E.-S.; Tan N.Y.Q.; Taylor K.D.; Teren A.; Tham Y.-C.; Thiery J.; Thio C.H.L.; Thomsen H.; Thorsteinsdottir U.; Tonjes A.; Tremblay J.; Uitterlinden A.G.; van der Harst P.; Verweij N.; Vogelezang S.; Volker U.; Waldenberger M.; Wang C.; Wilson O.D.; Wong C.; Wong T.-Y.; Yang Q.; Yasuda M.; Akilesh S.; Bochud M.; Boger C.A.; Devuyst O.; Edwards T.L.; Ho K.; Morris A.P.; Parsa A.; Pendergrass S.A.; Psaty B.M.; Rotter J.I.; Stefansson K.; Wilson J.G.; Susztak K.; Snieder H.; Heid I.M.; Scholz M.; Butterworth A.S.; Hung A.M.; Pattaro C.; Kottgen A./titolo:Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria/doi:10.1038%2Fs41467-019-11576-0/rivista:Nature communications/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:10

Publisher's version (útgefin grein).
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb733a69b246c6a1b99c26277821ed0d