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CP-673451, a Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor, Induces Apoptosis in Opisthorchis viverrini -Associated Cholangiocarcinoma via Nrf2 Suppression and Enhanced ROS.

Autor: Duangdara J; Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Boonsri B; Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Songkhla 90110, Thailand., Sayinta A; Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Division of Basic and Medical Sciences, Faculty of Allied Health Sciences, Pathumthani University, Pathum Thani 12000, Thailand., Supradit K; Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Department of Radiological Technology, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand., Thintharua P; Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Chakri Naruebodindra Medical Institute (CNMI), Faculty of Medicine Ramathibodi Hospital, Samut Prakan 10540, Thailand., Kumkate S; Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Suriyonplengsaeng C; Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Larbcharoensub N; Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Mingphruedhi S; Department of Surgery, Hepato-Pancreato-Biliary Division, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Rungsakulkij N; Department of Surgery, Hepato-Pancreato-Biliary Division, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Muangkaew P; Department of Surgery, Hepato-Pancreato-Biliary Division, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Tangtawee P; Department of Surgery, Hepato-Pancreato-Biliary Division, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Vassanasiri W; Department of Surgery, Hepato-Pancreato-Biliary Division, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Suragul W; Department of Surgery, Hepato-Pancreato-Biliary Division, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Janvilisri T; Graduate Program in Molecular Medicine, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Tohtong R; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Bates DO; Centre for Cancer Sciences, Division of Cancer and Stem Cells, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK., Wongprasert K; Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Dec 20; Vol. 17 (1). Date of Electronic Publication: 2023 Dec 20.