Gut microbiota diversity repeatedly diminishes over time following maintenance infliximab infusions in paediatric IBD patients.

Autor: Carlsen K; Department of Paediatrics and Adolescence, Copenhagen University Hospital-Amager Hvidovre Hospital, Hvidovre, Denmark.; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescent and Adults, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark., Thingholm LB; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Dempfle A; Institut für Medizinische Informatik und Statistik, Universitätsklinikum Schleswig-Holstein, Christian-Albrechts-Universität zu Kiel, Kiel, Germany., Malham M; Department of Paediatrics and Adolescence, Copenhagen University Hospital-Amager Hvidovre Hospital, Hvidovre, Denmark.; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescent and Adults, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark., Bang C; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Wewer V; Department of Paediatrics and Adolescence, Copenhagen University Hospital-Amager Hvidovre Hospital, Hvidovre, Denmark.; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescent and Adults, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark.

Publikováno v: PloS one [PLoS One] 2024 Dec 12; Vol. 19 (12), pp. e0311604. Date of Electronic Publication: 2024 Dec 12 (Print Publication: 2024).

Reporting guidelines for human microbiome research: the STORMS checklist.

Autor: Mirzayi C; CUNY Graduate School of Public Health and Health Policy, Institute for Implementation Science in Public Health, New York, NY, USA., Renson A; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zohra F; CUNY Graduate School of Public Health and Health Policy, Institute for Implementation Science in Public Health, New York, NY, USA., Elsafoury S; CUNY Graduate School of Public Health and Health Policy, Institute for Implementation Science in Public Health, New York, NY, USA., Geistlinger L; CUNY Graduate School of Public Health and Health Policy, Institute for Implementation Science in Public Health, New York, NY, USA., Kasselman LJ; CUNY Graduate School of Public Health and Health Policy, Institute for Implementation Science in Public Health, New York, NY, USA., Eckenrode K; CUNY Graduate School of Public Health and Health Policy, Institute for Implementation Science in Public Health, New York, NY, USA., van de Wijgert J; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Loughman A; Food & Mood Centre, The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria, Australia., Marques FZ; Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University, Melbourne, Victoria, Australia., MacIntyre DA; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Arumugam M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Azhar R; CUNY Graduate School of Public Health and Health Policy, Institute for Implementation Science in Public Health, New York, NY, USA., Beghini F; Department CIBIO, University of Trento, Trento, Italy., Bergstrom K; Department of Biology, University of British Columbia-Okanagan Campus, Kelowna, British Columbia, Canada., Bhatt A; Division of Hematology and Division of Bone Marrow Transplantation, Department of Medicine, and Department of Genetics, Stanford University, Stanford, CA, USA., Bisanz JE; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA., Braun J; Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bravo HC; Genentech, South San Francisco, CA, USA., Buck GA; Center for Microbiome Engineering and Data Analysis, Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA., Bushman F; University of Pennsylvania, Philadelphia, PA, USA., Casero D; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Clarke G; Department of Psychiatry and Neurobehavioural Science, and APC Microbiome Ireland, University College Cork, Cork, Ireland., Collado MC; Institute of Agrochemistry and Food Technology-National Research Council, Valencia, Spain., Cotter PD; Teagasc Food Research Centre-Moorepark, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland.; VistaMilk, Cork, Ireland., Cryan JF; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Demmer RT; School of Public Health, University of Minnesota, Minneapolis, MN, USA., Devkota S; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Elinav E; Immunology Department, Weizmann Institute of Science, Rehovot, Israel.; Microbiome and Cancer Division, Deutsches Krebsforschungszentrum, Heidelberg, Germany., Escobar JS; Vidarium-Nutrition, Health and Wellness Research Center, Grupo Empresarial Nutresa, Medellin, Colombia., Fettweis J; Center for Microbiome Engineering and Data Analysis, Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA., Finn RD; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK., Fodor AA; Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA., Forslund S; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité University Hospital, Berlin, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Furlanello C; HK3 Lab, Rovereto, Italy., Gilbert J; Department of Pediatrics and Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA., Grice E; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Haibe-Kains B; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Handley S; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Herd P; McCourt School of Public Policy, Georgetown University, Washington, DC, USA., Holmes S; Department of Statistics, Stanford University, Stanford, CA, USA., Jacobs JP; Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Karstens L; Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USA., Knight R; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA., Knights D; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA.; Biotechnology Institute, University of Minnesota, Saint Paul, MN, USA., Koren O; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel., Kwon DS; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Langille M; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada., Lindsay B; University of Maryland School of Medicine, Institute of Human Virology, Baltimore, MD, USA., McGovern D; F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., McHardy AC; Department of Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Brunswick, Germany., McWeeney S; OHSU Knight Cancer Institute, Portland, OR, USA., Mueller NT; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Nezi L; Department of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Europeo di Oncologia, Milan, Italy., Olm M; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA., Palm N; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Pasolli E; Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy., Raes J; Department of Microbiology and Immunology, Rega institute, KU Leuven and VIB Center for Microbiology, Leuven, Belgium., Redinbo MR; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rühlemann M; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany., Balfour Sartor R; Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Schloss PD; Department of Microbiology & Immunology, University of Michigan, Ann Arbor, MI, USA., Schriml L; University of Maryland School of Medicine, Institute for Genome Sciences, Baltimore, MD, USA., Segal E; Department of Computer Science, Weizmann Institute of Science, Rehovot, Israel., Shardell M; University of Maryland School of Medicine, Institute for Genome Sciences, Baltimore, MD, USA., Sharpton T; Department of Microbiology and Department of Statistics, Oregon State University, Corvallis, OR, USA., Smirnova E; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, USA., Sokol H; Gastroenterology Department, Centre de Recherche Saint-Antoine, INSERM, Assistance Publique-Hôpitaux de Paris, Saint Antoine Hospital, Sorbonne Université, Paris, France., Sonnenburg JL; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA., Srinivasan S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Thingholm LB; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany., Turnbaugh PJ; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Upadhyay V; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Walls RL; Critical Path Institute, Tucson, AZ, USA., Wilmes P; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Yamada T; Department of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan., Zeller G; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Zhang M; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Zhao N; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Zhao L; Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA., Bao W; JMP Life Sciences, SAS Institute, Cary, NC, USA., Culhane A; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Devanarayan V; Eisai, Woodcliff Lake, NJ, USA., Dopazo J; Clinical Bioinformatics Area, Hospital Virgen del Rocio, Sevilla, Spain., Fan X; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China., Fischer M; Experimental Pediatric Oncology, University Children's Hospital, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University of Cologne, Cologne, Germany., Jones W; Q2 Solutions-EA Genomics, Durham, NC, USA., Kusko R; Immuneering, Cambridge, MA, USA., Mason CE; Weill Cornell Medicine, New York, NY, USA., Mercer TR; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia., Sansone SA; Oxford e-Research Centre, Department of Engineering Science, University of Oxford, Oxford, UK., Scherer A; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Shi L; State Key Laboratory of Genetic Engineering, Human Phenome Institute, School of Life Sciences and Shanghai Cancer Center, Fudan University, Shanghai, China., Thakkar S; Office of Computational Science, Office of Translational Sciences, Center for Drug Evaluation and Research, Washington, DC, USA., Tong W; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food & Drug Administration, Jefferson, AR, USA., Wolfinger R; Scientific Discovery and Genomics, SAS Institute, Cary, NC, USA., Hunter C; GigaScience Database, BGI Hong Kong, Hong Kong, China., Segata N; Department CIBIO, University of Trento, Trento, Italy.; Department of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Europeo di Oncologia, Milan, Italy., Huttenhower C; Harvard T. H. Chan School of Public Health, Boston, MA, USA., Dowd JB; Department of Sociology, Leverhulme Centre for Demographic Science, University of Oxford, Oxford, UK., Jones HE; CUNY Graduate School of Public Health and Health Policy, Institute for Implementation Science in Public Health, New York, NY, USA., Waldron L; CUNY Graduate School of Public Health and Health Policy, Institute for Implementation Science in Public Health, New York, NY, USA. levi.waldron@sph.cuny.edu.

Publikováno v: Nature medicine [Nat Med] 2021 Nov; Vol. 27 (11), pp. 1885-1892. Date of Electronic Publication: 2021 Nov 17.

Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis.

Autor: Kummen M; Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Department of Oncology, Oslo University Hospital, Oslo, Norway., Thingholm LB; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Rühlemann MC; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Holm K; Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway., Hansen SH; Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway., Moitinho-Silva L; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany., Liwinski T; Institute of Medical Systems Biology, Center for Molecular Neurobiology, Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zenouzi R; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Storm-Larsen C; Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway., Midttun Ø; Bevital, Bergen, Norway., McCann A; Bevital, Bergen, Norway., Ueland PM; Bevital, Bergen, Norway., Høivik ML; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterology, Oslo University Hospital Ullevål, Oslo, Norway., Vesterhus M; Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Department of Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway., Trøseid M; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway., Laudes M; Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine 1, University of Kiel, Kiel, Germany., Lieb W; Institute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany., Karlsen TH; Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway., Bang C; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Schramm C; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Martin Zeitz Centre for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Hov JR; Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. Electronic address: j.e.r.hov@medisin.uio.no.

Publikováno v: Gastroenterology [Gastroenterology] 2021 Apr; Vol. 160 (5), pp. 1784-1798.e0. Date of Electronic Publication: 2020 Dec 31.

Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.

Autor: Rühlemann MC; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Hermes BM; Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.; Institute of Experimental Medicine, Kiel University, Kiel, Germany.; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany., Bang C; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Doms S; Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.; Institute of Experimental Medicine, Kiel University, Kiel, Germany., Moitinho-Silva L; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.; Department of Dermatology, Kiel University, Kiel, Germany., Thingholm LB; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Frost F; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany., Degenhardt F; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Wittig M; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Kässens J; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Weiss FU; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Neuhaus K; ZIEL-Institute for Food & Health, Technical University of Munich, Freising, Germany., Völker U; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Völzke H; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Weiss S; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Grallert H; Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Laudes M; Department of Internal Medicine 1, Kiel University, Kiel, Germany., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Haller D; ZIEL-Institute for Food & Health, Technical University of Munich, Freising, Germany.; Chair of Nutrition and Immunology, Technical University of Munich, Freising, Germany., Lerch MM; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany., Baines JF; Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.; Institute of Experimental Medicine, Kiel University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany. a.franke@mucosa.de.

Publikováno v: Nature genetics [Nat Genet] 2021 Feb; Vol. 53 (2), pp. 147-155. Date of Electronic Publication: 2021 Jan 18.

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.

Autor: Pryor R; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., Norvaisas P; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., Marinos G; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany., Best L; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany., Thingholm LB; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24105 Kiel, Germany., Quintaneiro LM; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., De Haes W; Molecular and Functional Neurobiology, Department of Biology, KU Leuven, 3000 Leuven, Belgium., Esser D; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany., Waschina S; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany., Lujan C; UCL Cancer Institute, University College London, London WC1E 6JD, UK., Smith RL; Laboratory of Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands., Scott TA; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., Martinez-Martinez D; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK., Woodward O; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK., Bryson K; Department of Computer Science, University College London, London WC1E 6BT, UK., Laudes M; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Lieb W; Institute of Epidemiology, Christian Albrechts University Kiel, 24105 Kiel, Germany., Houtkooper RH; Laboratory of Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands., Franke A; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24105 Kiel, Germany., Temmerman L; Molecular and Functional Neurobiology, Department of Biology, KU Leuven, 3000 Leuven, Belgium., Bjedov I; UCL Cancer Institute, University College London, London WC1E 6JD, UK., Cochemé HM; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK., Kaleta C; Institute for Experimental Medicine, Kiel University, 24105 Kiel, Germany. Electronic address: c.kaleta@iem.uni-kiel.de., Cabreiro F; MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK; Institute of Structural and Molecular Biology, University College London and Birkbeck, London WC1E 6BT, UK. Electronic address: f.cabreiro@lms.mrc.ac.uk.

Publikováno v: Cell [Cell] 2019 Sep 05; Vol. 178 (6), pp. 1299-1312.e29. Date of Electronic Publication: 2019 Aug 29.