Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Thimo Rohlf"'
Autor:
Lydia Steiner, Lydia Hopp, Henry Wirth, Jörg Galle, Hans Binder, Sonja J Prohaska, Thimo Rohlf
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46811 (2012)
Current genome-wide ChIP-seq experiments on different epigenetic marks aim at unraveling the interplay between their regulation mechanisms. Published evaluation tools, however, allow testing for predefined hypotheses only. Here, we present a novel me
Externí odkaz:
https://doaj.org/article/2d139c956d2a410094684f9affbf1d5a
Publikováno v:
Aging Cell
During aging, a decline in stem cell function is observed in many tissues. This decline is accompanied by complex changes of the chromatin structure among them changes in histone modifications and DNA methylation which both affect transcription of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac2a0c2a3714643ba5df61eea4111bd
https://doi.org/10.1111/acel.12177
https://doi.org/10.1111/acel.12177
Publikováno v:
BioEssays. 34:841-848
Epigenetic control of gene expression by chromatin remodeling is critical for adult stem cell function. A decline in stem cell function is observed during aging, which is accompanied by changes in the chromatin structure that are currently unexplaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c752545e8ca0fb74d2608ce84000e48
https://doi.org/10.1002/bies.201100190
https://doi.org/10.1002/bies.201100190
Publikováno v:
Journal of Theoretical Biology. 264:838-846
Cancer invasion and metastasis depend on tumor-induced angiogenesis, the means by which cancer cells attract and maintain a blood supply. During angiogenesis, cellular processes are tightly coordinated by signaling molecules and their receptors. Unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18826bb0aa2c5628da7f033dc1d40a29
https://doi.org/10.1016/j.jtbi.2010.03.025
https://doi.org/10.1016/j.jtbi.2010.03.025
Publikováno v:
International Journal of Nanotechnology and Molecular Computation. 1:58-76
Highly structured mesh- or crossbar-like nanoscale architectures have been proposed in the past as possible alternatives to the von Neumann computing architecture. While the top-down engineered semi-conducting technology favors regular and locally in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8b544d352927b859d09fa18dec78dcc
https://doi.org/10.4018/jnmc.2009120904
https://doi.org/10.4018/jnmc.2009120904
Autor:
Christopher R. Winkler, Thimo Rohlf
Publikováno v:
Advances in Complex Systems. 12:293-310
Genetic regulation is a key component in development, but a clear understanding of the structure and dynamics of genetic networks is not yet at hand. In this paper we investigate these properties within an artificial genome model originally introduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40602c0e8f64df1ab2587863c0426d7
https://doi.org/10.1142/s0219525909002210
https://doi.org/10.1142/s0219525909002210
Autor:
Constantino Tsallis, Thimo Rohlf
Publikováno v:
Physica A: Statistical Mechanics and its Applications. 379:465-470
We numerically study the dynamics of elementary 1D cellular automata (CA), where the binary state $\sigma_i(t) \in \{0,1\}$ of a cell $i$ does not only depend on the states in its local neighborhood at time $t-1$, but also on the memory of its own pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb1b2b64f2780812ec48641c67530f3
https://doi.org/10.1016/j.physa.2007.02.015
https://doi.org/10.1016/j.physa.2007.02.015
Publikováno v:
Translational Bioinformatics ISBN: 9789401799263
The stem cell epigenome reflects a sensitive balance of chromatin (de-)modification processes. Here, we review our recent achievements towards a mechanistic understanding of this balance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2505f306d09fd216f3546fd20c4fcebf
https://doi.org/10.1007/978-94-017-9927-0_7
https://doi.org/10.1007/978-94-017-9927-0_7
Autor:
Thimo Rohlf, Stefan Bornholdt
Publikováno v:
Physical Review Letters. 84:6114-6117
We evolve network topology of an asymmetrically connected threshold network by a simple local rewiring rule: quiet nodes grow links, active nodes lose links. This leads to convergence of the average connectivity of the network towards the critical va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f269448b61a09ecc555dd805e4c276b4
https://doi.org/10.1103/physrevlett.84.6114
https://doi.org/10.1103/physrevlett.84.6114
Publikováno v:
Epigenomics. 4(2)
Epigenetic mechanisms play an important role in regulating and stabilizing functional states of living cells. However, in spite of an increasing amount of experimental data, models of transcriptional regulation by epigenetic processes, in particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a41c0bc90042ee92768f5ab4d90c102
https://pubmed.ncbi.nlm.nih.gov/22449191
https://pubmed.ncbi.nlm.nih.gov/22449191