Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Thimmas"'
Autor:
Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostrander, Lucas Showman, Chong Wang, Thimmasettappa Thippeswamy
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-25 (2023)
Abstract Background Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration,
Externí odkaz:
https://doaj.org/article/27b5448e94704f1a86180ed9deaf58b0
Autor:
Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 399-410 (2023)
Abstract Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex
Externí odkaz:
https://doaj.org/article/5cf3a7149c2048d9ab198687bb4291b4
Autor:
Sharda Sambhakar, Shwetha S Kamath K, Thimmasetty J, Shashank Nayak N, Bishambar Singh, Paramita Das
Publikováno v:
RGUHS Journal of Pharmaceutical Sciences, Vol 14, Iss 3 (2024)
Background This current research work discusses the Aripiprazolersquos solubility behaviour in individual solvents and solvent blends to offer some theoretical foundation for the formulation scientists regarding solute solvent interactions. AimsObjec
Externí odkaz:
https://doaj.org/article/dd5ba1c29d884d5590f09bb1a40876ed
Autor:
Suraj S. Vasanthi, Nyzil Massey, Suresh N. Nair, Jonathan P. Mochel, Lucas Showman, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Saracatinib/AZD0530 (SAR), a Src tyrosine kinase inhibitor, mitigates seizure-induced brain pathology in epilepsy models upon repeated oral dosing. However, repeated dosing is stressful and can be challenging in some seizing animals. To overcome this
Externí odkaz:
https://doaj.org/article/7c514cee98144e1db9ae0052e453e9fa
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Neurodegeneration and neuroinflammation are key processes of epileptogenesis in temporal lobe epilepsy (TLE). A considerable number (∼30%) of patients with epilepsy are resistant to currently available antiseizure drugs and thus there is a need to
Externí odkaz:
https://doaj.org/article/80bd9bddf2c642c8ae1500f79d473c8a
Autor:
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Organophosphates (OP) are highly toxic chemical nerve agents that have been used in chemical warfare. Currently, there are no effective medical countermeasures (MCMs) that mitigate the chronic effects of OP exposure. Oxidative stress is a key mechani
Externí odkaz:
https://doaj.org/article/ee60e460bdda414980be652438df1986
Autor:
Christina Meyer, Elizabeth Grego, Suraj S. Vasanthi, Nikhil S. Rao, Nyzil Massey, Claire Holtkamp, Joselyn Huss, Lucas Showman, Balaji Narasimhan, Thimmasettappa Thippeswamy
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2061 (2023)
NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitoc
Externí odkaz:
https://doaj.org/article/331dd32870e5452ba3ebce96b8785c24
Autor:
Nyzil Massey, Suraj Sundara Vasanthi, Manikandan Samidurai, Meghan Gage, Nikhil Rao, Christina Meyer, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Organophosphate nerve agent (OPNA) exposure induces acute and long-term neurological deficits. OPNA exposure at sub-lethal concentrations induces irreversible inhibition of acetylcholinesterase and cholinergic toxidrome and develops status epilepticu
Externí odkaz:
https://doaj.org/article/5bcec7d195a74a1fbab94e68ca61bb2b
Autor:
Nikhil S. Rao, Christina Meyer, Suraj S. Vasanthi, Nyzil Massey, Manikandan Samidurai, Meghan Gage, Marson Putra, Aida N. Almanza, Logan Wachter, Thimmasettappa Thippeswamy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Sex is a biological variable in experimental models. In our previous diisopropylfluorophosphate (DFP) studies, female rats required a higher dose of DFP to achieve a somewhat similar severity of status epilepticus (SE) as males. In those studies, mal
Externí odkaz:
https://doaj.org/article/3365a7c48d5447a38cc68c990cfcd13b
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 10, Iss 2, Pp 203-212 (2020)
Pharmaceutical co-crystals are novel class of pharmaceutical substances, which possess an apparent probability of advancement of polished physical properties offering stable and patentable solid forms. These multi-component crystalline forms influenc
Externí odkaz:
https://doaj.org/article/ce254798e8b743fd97da4fb634d5c82a