Výsledky vyhledávání

The influence of differently functionalized nanodiamonds on proliferation, apoptosis and EMT/MET phenomena in 2D and 3D tumor cell cultures

Autor: Matthias Peindl, Anke Krueger, Anup James Shirley, Sarah Schweeberg, Gudrun Dandekar, Thilo Waag, Franz Jakob, Regina Ebert, Heike Walles

Publikováno v: Journal of Materials Chemistry B. 9:9395-9405

Nanodiamonds (ND) have been suggested to have several potential uses in biomedicine, since they are seemingly biocompatible. However, data about the biological effects of ND in physiological conditions are scarce. In this study, we observed that pros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18e2d26917ac25e8f72b7195d557935
https://doi.org/10.1039/d1tb01739j

Zobrazit plný text záznamu

Functionalization of bone implants with nanodiamond particles and angiopoietin-1 to improve vascularization and bone regeneration

Autor: Anke Krueger, Michael Rasse, Martin Funk, Thomas Meinhardt, Michela Bruschi, Yuan Tian, Sarah Schweeberg, Doris Steinmüller-Nethl, Xujun Wu, Thilo Waag, Robert Stigler, Karin Larsson

Publikováno v: Journal of materials chemistry. B. 5(32)

One of the major challenges in bone tissue engineering is adequate vascularization within bone substituents for nutrients and oxygen supply. In this study, the production and results of a new, highly functional bone construct consisting of a commerci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07f1ef39adf73f69983f70b27617b51
https://pubmed.ncbi.nlm.nih.gov/32264425

Zobrazit plný text záznamu

Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes

Autor: Thilo Waag, Doris Steinmüller-Nethl, Anne Christine Johannessen, Anke Krueger, Emmet McCormack, Salwa Suliman, Amani O. Hamza, Kamal Mustafa, Tereza Osdal, Daniela Elena Costea, Anna Finne-Wistrand, Himalaya Parajuli, Joachim Nickel, Yang Sun

Publikováno v: Biomaterials. 95:11-21

This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance osteoinductivity. Culturin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adac0b01814efcc02e2d7244d028dc04
https://doi.org/10.1016/j.biomaterials.2016.04.002

Zobrazit plný text záznamu

Biofunctionalization of scaffold material with nano-scaled diamond particles physisorbed with angiogenic factors enhances vessel growth after implantation

Autor: Johann Kern, Thilo Waag, Günter Lepperdinger, Anke Krueger, Peter Buschmann, Magdalena M. Schimke, Michael Rasse, Robert Stigler, Doris Steinmüller-Nethl, Gerold Untergasser, Xujun Wu

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 12:823-833

Biofunctionalized scaffold facilitates complete healing of large defects. Biological constraints are induction and ingrowth of vessels. Angiogenic growth factors such as vascular endothelial growth factor or angiopoietin-1 can be bound to nano-scaled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca11d3ceeba67446baaaa8fa4a644d55
https://doi.org/10.1016/j.nano.2015.11.004

Zobrazit plný text záznamu

Disaggregation and Anionic Activation of Nanodiamonds Mediated by Sodium Hydride-A New Route to Functional Aliphatic Polyester-Based Nanodiamond Materials

Autor: Anke Krueger, Peter Olsén, Anna Finne-Wistrand, Ann-Christine Albertsson, Doris Steinmüller-Nethl, Yang Sun, Thilo Waag

Publikováno v: Particle & Particle Systems Characterization. 32:35-42

The treatment of bone defects is facing the situation of lacking donations for autotransplantation. As a valid approach, scaffold-based tissue engineering combines the construction of well-defined porous scaffolds with advanced cell culturing technol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e90c54187e8d3fb2eafa117d3bca3bce
https://doi.org/10.1002/ppsc.201400098

Zobrazit plný text záznamu

A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration

Autor: Anke Krueger, Doris Steinmüller-Nethl, Mohammed A. Yassin, Kamal Mustafa, Zhe Xing, Yang Sun, Anna Finne-Wistrand, Thilo Waag, Knut N. Leknes, Kristine Eldevik Fasmer

Publikováno v: Macromolecular bioscience. 17(6)

Functionalizing polymer scaffolds with nanodiamond particles (nDPs) has pronounced effect on the surface properties, such as improved wettability, an increased active area and binding sites for cellular attachment and adhesion, and increased ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0bf0399342d5c549aacdaa2b13541a
https://pubmed.ncbi.nlm.nih.gov/28116858

Zobrazit plný text záznamu

In vivo host response and degradation of copolymer scaffolds functionalized with nanodiamonds and bone morphogenetic protein 2

Autor: Anke Krueger, Salwa Suliman, Ying Xue, Doris Steinmüller-Nethl, Kamal Mustafa, Anna Finne-Wistrand, Daniela Elena Costea, Yang Sun, Thilo Waag, Torbjorn O. Pedersen, Joachim Nickel

The aim is to evaluate the effect of modifying poly[(l-lactide)-co-(e-caprolactone)] scaffolds (PLCL) with nanodiamonds (nDP) or with nDP+physisorbed BMP-2 (nDP+BMP-2) on in vivo host tissue response and degradation. The scaffolds are implanted subcu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e07b4602bf961213b6a573ba978e9ca
https://hdl.handle.net/1956/15338

Zobrazit plný text záznamu

Biological Effects of Functionalizing Copolymer Scaffolds with Nanodiamond Particles

Autor: Zhe Xing, Xujun Wu, Kamal Mustafa, Frank Kloss, Anke Krueger, Yang Sun, Doris Steinmüller-Nethl, Thilo Waag, Anna Finne-Wistrand, Torbjorn O. Pedersen, Ying Xue

Publikováno v: Tissue Engineering Part A; Vol 19

Significant evidence has indicated that poly(L-lactide)-co-(epsilon-caprolactone) [(poly(LLA-co-CL)] scaffolds could be one of the suitable candidates for bone tissue engineering. Oxygen-terminated nanodiamond particles (n-DP) were combined with poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31bdcefb48c5295e4dc460cb2f6d4fb
https://europepmc.org/articles/PMC3700016/

Zobrazit plný text záznamu

Allicin and derivates are cysteine protease inhibitors with antiparasitic activity

Autor: Matthias Leippe, August Stich, Thilo Waag, Tanja Schirmeister, Jennifer Rath, Christoph Gelhaus

Publikováno v: Bioorganicmedicinal chemistry letters. 20(18)

Allicin and derivatives thereof inhibit the CAC1 cysteine proteases falcipain 2, rhodesain, cathepsin B and L in the low micromolar range. The structure-activity relationship revealed that only derivatives with primary carbon atom in vicinity to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de2ef31029fe3c2d15ab6b1ec65aefd
https://pubmed.ncbi.nlm.nih.gov/20692829

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání