Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Thilo Speckmann"'
Autor:
Meriem Ouni, Fabian Eichelmann, Markus Jähnert, Christin Krause, Sophie Saussenthaler, Christiane Ott, Pascal Gottmann, Thilo Speckmann, Peter Huypens, Stefan Wolter, Oliver Mann, Martin Hrabé De Angelis, Johannes Beckers, Henriette Kirchner, Matthias B. Schulze, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101774- (2023)
Objectives: Better disease management can be achieved with earlier detection through robust, sensitive, and easily accessible biomarkers. The aim of the current study was to identify novel epigenetic biomarkers determining the risk of type 2 diabetes
Externí odkaz:
https://doaj.org/article/cbd304180aef4bbdad8c44ce9af6265c
Autor:
Leona Kovac, Thilo Speckmann, Markus Jähnert, Pascal Gottmann, Louise Fritsche, Hans-Ulrich Häring, Andreas L. Birkenfeld, Andreas Fritsche, Annette Schürmann, Meriem Ouni
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15673 (2023)
MicroRNAs (miRNAs) recently emerged as means of communication between insulin-sensitive tissues to mediate diabetes development and progression, and as such they present a valuable proxy for epigenetic alterations associated with type 2 diabetes. In
Externí odkaz:
https://doaj.org/article/36e2261c5b244496827683264c63ee65
Autor:
Alexis Z.L. Shih, Yi-Chun Chen, Thilo Speckmann, Esben Søndergaard, Annette Schürmann, C. Bruce Verchere, Thomas E. Willnow
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101585- (2022)
Objective: Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic studies show that S
Externí odkaz:
https://doaj.org/article/794e8a6764884d43b3adb7139efce1e0
Publikováno v:
Molecular Metabolism, Vol 21, Iss , Pp 1-12 (2019)
Background: The divalent cation Calcium (Ca2+) regulates a wide range of processes in disparate cell types. Within insulin-producing β-cells, increases in cytosolic Ca2+ directly stimulate insulin vesicle exocytosis, but also initiate multiple signa
Externí odkaz:
https://doaj.org/article/b8465ce0afbe4e93b3110bb581113235
Autor:
Wenke Jonas, Oliver Kluth, Anett Helms, Sarah Voß, Markus Jähnert, Pascal Gottmann, Thilo Speckmann, Birgit Knebel, Alexandra Chadt, Hadi Al-Hasani, Annette Schürmann, Heike Vogel
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3205 (2022)
Current attempts to prevent and manage type 2 diabetes have been moderately effective, and a better understanding of the molecular roots of this complex disease is important to develop more successful and precise treatment options. Recently, we initi
Externí odkaz:
https://doaj.org/article/3654d5968a2f4a68a0c3a5d64b01c21b
Autor:
Paul V. Sabatini, Thilo Speckmann, Cuilan Nian, Maria M. Glavas, Chi Kin Wong, Ji Soo Yoon, Tatsuya Kin, A.M. James Shapiro, William T. Gibson, C. Bruce Verchere, Francis C. Lynn
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 163-174 (2018)
Summary: Depolarization of neuroendocrine cells results in calcium influx, which induces vesicle exocytosis and alters gene expression. These processes, along with the restoration of resting membrane potential, are energy intensive. We hypothesized t
Externí odkaz:
https://doaj.org/article/7b8849adfc394379875cec3389786339
Publikováno v:
Diabetes. 66:2213-2219
The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in Sox4 are associated with an increased risk of developing type 2 diabetes. We used an inducible β-cell knocko
Publikováno v:
Molecular Metabolism
Background The divalent cation Calcium (Ca2+) regulates a wide range of processes in disparate cell types. Within insulin-producing β-cells, increases in cytosolic Ca2+ directly stimulate insulin vesicle exocytosis, but also initiate multiple signal
Publikováno v:
Journal of Biological Chemistry. 291:2682-2695
Cytosolic calcium influx activates signaling pathways known to support pancreatic beta cell function and survival by modulating gene expression. Impaired calcium signaling leads to decreased beta cell mass and diabetes. To appreciate the causes of th
Autor:
Chi Kin Wong, Ji Soo Yoon, Cuilan Nian, C. Bruce Verchere, Tatsuya Kin, Francis C. Lynn, William T. Gibson, Maria M. Glavas, A. M. James Shapiro, Thilo Speckmann, Paul V. Sabatini
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 163-174 (2018)
Summary: Depolarization of neuroendocrine cells results in calcium influx, which induces vesicle exocytosis and alters gene expression. These processes, along with the restoration of resting membrane potential, are energy intensive. We hypothesized t