Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Thilo S. Lange"'
Autor:
Thilo S. Lange, Kyu Kwang Kim, Rakesh K. Singh, Robert M. Strongin, Carolyn K. McCourt, Laurent Brard
Publikováno v:
PLoS ONE, Vol 3, Iss 7 (2008)
Externí odkaz:
https://doaj.org/article/793cc3c1d46b4a69ad75acf81e19e542
Autor:
Junsuk Ko, Gaurav Choudhary, Alexis White, Qing Lu, Sharon Rounds, Zhengke Wang, Thilo S. Lange, Xing Wang
Publikováno v:
Am J Respir Cell Mol Biol
Cigarette smoke (CS) exposure increases the risk for acute respiratory distress syndrome in humans and promotes alveolar–capillary barrier permeability and acute lung injury in animal models. However, the underlying mechanisms are not well understo
Publikováno v:
Drug Design, Development and Therapy, Vol 2009, Iss default, Pp 17-26 (2008)
Thilo S Lange1,2, Carolyn McCourt2, Rakesh K Singh2, Kyu Kwang Kim2, Ajay P Singh3, Brian S Luisi4, Onur Alptürk5, Robert M Strongin6, Laurent Brard21Division of Biology and Medicine Brown University, Providence, R1, USA; 2Molecular Therapeutics Lab
Externí odkaz:
https://doaj.org/article/ca313ff3586c438395941df776437e39
Autor:
Eboni Chambers, Gaurav Choudhary, Hongwei Yao, Diana Borgas, Julie Newton, Thilo S. Lange, Rajshekhar Basak, Qing Lu, Miles A. Mundy, Mahogany Oldham, Sharon Rounds
Inhalation of acrolein, a highly reactive aldehyde, causes lung edema. The underlying mechanism is poorly understood and there is no effective treatment. In this study, we demonstrated that acrolein not only dose-dependently induced lung edema but al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e810e7da0611fcb0064c609b981adaac
https://europepmc.org/articles/PMC5765414/
https://europepmc.org/articles/PMC5765414/
Autor:
Nicholi Vorsa, Preetpal S. Sidhu, Thilo S. Lange, Laurent Brard, N. Kawar, Russell Hopson, Timothy C. Horan, Shannon MacLaughlan, James F. Padbury, Richard G. Moore, Alper Uzun, Rakesh K. Singh, Ajay P. Singh, Kyle A. Glass, Sunil K. Shaw, Leggy A. Arnold, Kyu K. Kim
Publikováno v:
Genes & Cancer. 4:524-534
Hypercalcemia remains a major impediment to the clinical use of vitamin D in cancer treatment. Approaches to remove hypercalcemia and development of nonhypercalcemic agents can lead to the development of vitamin D-based therapies for treatment of var
Autor:
Nicholi Vorsa, Richard G. Moore, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Timothy C. Horan, Laurent Brard, Rakesh K. Singh
Publikováno v:
Chemical Biology & Drug Design. 79:92-103
This study determined the in vitro potential of novel compounds adamantyl-N-acetylcystein and adamantyl isothiocyanate to treat gynecological cancers. Adamantyl-N-acetylcystein is postulated to be an in vivo metabolite of adamantyl isothiocyanate as
Autor:
Kyu Kwang Kim, Katina Robison, Megan M. McCallum, Leggy A. Arnold, Thilo S. Lange, Rakesh K. Singh, Laurent Brard, Tahniyath Ara, Richard G. Moore
Publikováno v:
Gynecologic Oncology. 123:370-378
Objective In human trials calcitriol and its analogs displayed unacceptable systemic toxicities including hypercalcemia. This study was designed to evaluate a novel non-hypercalcemic vitamin-D derivative (MT19c) and its anticancer effects in cultured
Autor:
Giselle L. Saulnier Sholler, Yongping Zou, Kyu Kwang Kim, Katrin Kristjansdottir, Thilo S. Lange, Laurent Brard, Rakesh K. Singh
Publikováno v:
Chemical Biology & Drug Design. 76:164-173
Bromoacetoxy-calcidiol (B3CD), a pro-apoptotic and cytotoxic agent in neuroblastoma (NB) cell lines, displayed therapeutic potential in vivo as an anticancer drug in a NB xenograft mouse model. Tumors of all animals treated intraperitoneally with B3C
Publikováno v:
Investigational New Drugs. 29:63-72
Coumarin derivative RKS262 belongs to a new class of potential anti-tumor agents. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cel
Autor:
Laurent Brard, Ajay P. Singh, Onur Alpturk, Thilo S. Lange, Brian S. Luisi, Rakesh K. Singh, Robert M. Strongin, C.K. McCourt, Kyu Kwang Kim
Publikováno v:
Drug design, development and therapy
Thilo S Lange1,2, Carolyn McCourt2, Rakesh K Singh2, Kyu Kwang Kim2, Ajay P Singh3, Brian S Luisi4, Onur Alptürk5, Robert M Strongin6, Laurent Brard21Division of Biology and Medicine Brown University, Providence, R1, USA; 2Molecular Therapeutics Lab