Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Thilo S, Lange"'
Autor:
Junsuk Ko, Gaurav Choudhary, Alexis White, Qing Lu, Sharon Rounds, Zhengke Wang, Thilo S. Lange, Xing Wang
Publikováno v:
Am J Respir Cell Mol Biol
Cigarette smoke (CS) exposure increases the risk for acute respiratory distress syndrome in humans and promotes alveolar–capillary barrier permeability and acute lung injury in animal models. However, the underlying mechanisms are not well understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc7d846430fa91400cecd334e91fb4a
https://doi.org/10.1165/rcmb.2020-0008oc
https://doi.org/10.1165/rcmb.2020-0008oc
Publikováno v:
Drug Design, Development and Therapy, Vol 2009, Iss default, Pp 17-26 (2008)
Thilo S Lange1,2, Carolyn McCourt2, Rakesh K Singh2, Kyu Kwang Kim2, Ajay P Singh3, Brian S Luisi4, Onur Alptürk5, Robert M Strongin6, Laurent Brard21Division of Biology and Medicine Brown University, Providence, R1, USA; 2Molecular Therapeutics Lab
Externí odkaz:
https://doaj.org/article/ca313ff3586c438395941df776437e39
Autor:
Richard G Moore, Thilo S Lange, Katina Robinson, Kyu K Kim, Alper Uzun, Timothy C Horan, Nada Kawar, Naohiro Yano, Sharon R Chu, Quanfu Mao, Laurent Brard, Monique E DePaepe, James F Padbury, Leggy A Arnold, Alexander Brodsky, Tun-Li Shen, Rakesh K Singh
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34443 (2012)
BACKGROUND:Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hypercalcemia in human trials to treat cancer. We identified the first non-hypercalcemic anti-cancer vitamin D analog MT19c by altering the A-ring of er
Externí odkaz:
https://doaj.org/article/1ab19dbd7f644ccbadcc68da0d5af459
Autor:
Kyu Kwang Kim, Rakesh K Singh, Robert M Strongin, Richard G Moore, Laurent Brard, Thilo S Lange
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19049 (2011)
The objective of the present study was to investigate the specific effects of Iron(III)-salophene (Fe-SP) on viability, morphology, proliferation, cell cycle progression, ROS generation and pro-apoptotic MAPK activation in neuroblastoma (NB) cells. A
Externí odkaz:
https://doaj.org/article/48e9b7da7d8346f8aece9b095a7769b0
Autor:
Thilo S Lange, Kyu Kwang Kim, Rakesh K Singh, Robert M Strongin, Carolyn K McCourt, Laurent Brard
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2303 (2008)
In this pioneer study to the biological activity of organometallic compound Iron(III)-salophene (Fe-SP) the specific effects of Fe-SP on viability, morphology, proliferation, and cell-cycle progression on platinum-resistant ovarian cancer cell lines
Externí odkaz:
https://doaj.org/article/1e2cdd7b97df41f4b4091c2886e5c410
Autor:
Thilo S. Lange, Kyu Kwang Kim, Rakesh K. Singh, Robert M. Strongin, Carolyn K. McCourt, Laurent Brard
Publikováno v:
PLoS ONE, Vol 3, Iss 7 (2008)
Externí odkaz:
https://doaj.org/article/793cc3c1d46b4a69ad75acf81e19e542
Autor:
Eboni Chambers, Gaurav Choudhary, Hongwei Yao, Diana Borgas, Julie Newton, Thilo S. Lange, Rajshekhar Basak, Qing Lu, Miles A. Mundy, Mahogany Oldham, Sharon Rounds
Inhalation of acrolein, a highly reactive aldehyde, causes lung edema. The underlying mechanism is poorly understood and there is no effective treatment. In this study, we demonstrated that acrolein not only dose-dependently induced lung edema but al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e810e7da0611fcb0064c609b981adaac
https://europepmc.org/articles/PMC5765414/
https://europepmc.org/articles/PMC5765414/
Autor:
Nicholi Vorsa, Preetpal S. Sidhu, Thilo S. Lange, Laurent Brard, N. Kawar, Russell Hopson, Timothy C. Horan, Shannon MacLaughlan, James F. Padbury, Richard G. Moore, Alper Uzun, Rakesh K. Singh, Ajay P. Singh, Kyle A. Glass, Sunil K. Shaw, Leggy A. Arnold, Kyu K. Kim
Publikováno v:
Genes & Cancer. 4:524-534
Hypercalcemia remains a major impediment to the clinical use of vitamin D in cancer treatment. Approaches to remove hypercalcemia and development of nonhypercalcemic agents can lead to the development of vitamin D-based therapies for treatment of var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe48b8abc5ea0e9cf7203e9ca9af784b
https://doi.org/10.1177/1947601913507575
https://doi.org/10.1177/1947601913507575
Autor:
Nicholi Vorsa, Richard G. Moore, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Timothy C. Horan, Laurent Brard, Rakesh K. Singh
Publikováno v:
Chemical Biology & Drug Design. 79:92-103
This study determined the in vitro potential of novel compounds adamantyl-N-acetylcystein and adamantyl isothiocyanate to treat gynecological cancers. Adamantyl-N-acetylcystein is postulated to be an in vivo metabolite of adamantyl isothiocyanate as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a0faadc8759d856fd49e1d41ea3035c
https://doi.org/10.1111/j.1747-0285.2011.01251.x
https://doi.org/10.1111/j.1747-0285.2011.01251.x
Autor:
Kyu Kwang Kim, Katina Robison, Megan M. McCallum, Leggy A. Arnold, Thilo S. Lange, Rakesh K. Singh, Laurent Brard, Tahniyath Ara, Richard G. Moore
Publikováno v:
Gynecologic Oncology. 123:370-378
Objective In human trials calcitriol and its analogs displayed unacceptable systemic toxicities including hypercalcemia. This study was designed to evaluate a novel non-hypercalcemic vitamin-D derivative (MT19c) and its anticancer effects in cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796a3b65c7738df57de69a3d89456fbb
https://doi.org/10.1016/j.ygyno.2011.07.002
https://doi.org/10.1016/j.ygyno.2011.07.002