Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Thilo Berkenbusch"'
Autor:
Carl A. Busacca, Scot Campbell, XuWu Feng, Nelu Grinberg, Varsolona Richard J, Paul-James Jones, Xudong Wei, Nizar Haddad, Oliver Niemeier, Chris H. Senanayake, Wendelin Samstag, Heewon Lee, Juergen Schroeder, Jana Vitous, Vittorio Farina, Nina C. Gonnella, Thilo Berkenbusch, Earl Spinelli, John A. Smoliga, Jon C. Lorenz, Suresh R. Kapadia, Zhibin Li, Max Sarvestani, Anjan Saha
Publikováno v:
Asian Journal of Organic Chemistry. 1:80-89
A concise synthetic route for large-scale manufacture of the hepatitis C virus (HCV) protease inhibitor BI 201335 has been developed. A convergent synthetic design was achieved by using three advanced intermediates: a densely functionalized thiazole-
Publikováno v:
Advanced Synthesis & Catalysis. 350:1131-1148
Substituted C s -symmetric penta-1,4-dien-3-ols ("divinylcarbinols") containing cis- or trans-disubstituted C=C bonds were desymmetrized by asymmetric monoepoxidations. Sharpless conditions gave anti-configured monoepoxides. For cis,cis-divinylcarbin
Autor:
Thilo Berkenbusch, Reinhard Brückner
Publikováno v:
Synlett. :1813-1816
Divinylcarbinols 17 and 18, CS-symmetrical and cis-configured, were desymmetrized by Sharpless' asymmetric epoxidation. This furnished anti-configured monoepoxy alcohols 19 (85% ee) and 20 (94% ee), respectively, or theirmirror images (ent-19, 84% ee
Autor:
Thilo Berkenbusch, Reinhard Brückner
Publikováno v:
Tetrahedron. 54:11471-11480
An enantioselective synthesis of (+)-ginnol ( 17 ) illustrates how Sharpless' asymmetric dihydroxylation may be used for the asymmetric synthesis of monoalcohols. The dihydroxylation was perfomed with AD mix α and the unsaturated ester trans - 9 . T
Autor:
Reinhard Brückner, Thilo Berkenbusch
Publikováno v:
Tetrahedron. 54:11461-11470
A method for synthesizing optically active trans,trans-configurated α,β,γ-substituted γ-lactones is presented. Asymmetric hydroxylation of ester 8 with AD mix α (AD mix β) and subsequent dehydration provided butenolide S-6 (R-6). Conjugate addi
Autor:
Thilo Berkenbusch, Reinhard Brueckner
Publikováno v:
ChemInform. 30
Autor:
Reinhard Brueckner, Thilo Berkenbusch
Publikováno v:
ChemInform. 30
Publikováno v:
ChemInform. 36
4-tert-Butyl-2-cyclohexen-1-one dimerizes in THF solution via its kinetic enolate, leading to di-tert-butylditwistane 8 in up to 36% yield (−78 °C → room temp., protonolysis, flash chromatography). X-ray crystallography shows that 8 incorporates
Autor:
Thilo Berkenbusch, Reinhard Brückner
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 10(6)
The C(21)-C(38) fragment all-trans-41 of the unnatural enantiomer 1 of nystatin A(1) was prepared starting from the N-propionyl oxazolidinone 9. Aldol adduct ent-8 (ee > 96 %) derived in two steps was hydroborated with (thexyl)BH(2). Oxidative work-u
Autor:
Christian Harcken, Thilo Berkenbusch, Stefan Braukmuller, Andreas Umland, Konrad Siegel, Felix Gorth, Frank Von der Ohe, Reinhard Bruckner
Publikováno v:
ChemInform. 31