Výsledky vyhledávání - "Thilina D. Jayasinghe"

Akademický článek

Synthesis of C7/C8-cyclitols and C7N-aminocyclitols from maltose and X-ray crystal structure of Streptomyces coelicolor GlgEI V279S in a complex with an amylostatin GXG–like derivative

Autor: Radhika Thanvi, Thilina D. Jayasinghe, Sunayana Kapil, Babatunde Samuel Obadawo, Donald R. Ronning, Steven J. Sucheck

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

C7/C8-cyclitols and C7N-aminocyclitols find applications in the pharmaceutical sector as α-glucosidase inhibitors and in the agricultural sector as fungicides and insecticides. In this study, we identified C7/C8-cyclitols and C7N-aminocyclitols as p

Externí odkaz: https://doaj.org/article/28f1a9f932764776a7263e95a416094c

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Akademický článek

Stereoselective synthesis of a 4-⍺-glucoside of valienamine and its X-ray structure in complex with Streptomyces coelicolor GlgE1-V279S

Autor: Anshupriya Si, Thilina D. Jayasinghe, Radhika Thanvi, Donald R. Ronning, Steven J. Sucheck

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)

Abstract Glycoside hydrolases (GH) are a large family of hydrolytic enzymes found in all domains of life. As such, they control a plethora of normal and pathogenic biological functions. Thus, understanding selective inhibition of GH enzymes at the at

Externí odkaz: https://doaj.org/article/fc22d1fea7d74f8e857dd73e5c44bc81

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Targeting BRD4 and PI3K signaling pathways for the treatment of medulloblastoma

Autor: Bharti, Sethi, Virender, Kumar, Thilina D, Jayasinghe, Yuxiang, Dong, Donald R, Ronning, Haizhen A, Zhong, Donald W, Coulter, Ram I, Mahato

Publikováno v: Journal of Controlled Release. 354:80-90

Medulloblastoma (MB) is a malignant pediatric brain tumor which shows upregulation of MYC and sonic hedgehog (SHH) signaling. SHH inhibitor face acquired resistance, which is a major cause of relapse. Further, direct MYC oncogene inhibition is a chal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28b08d434f9640b5be15a5d68d7c2dc
https://doi.org/10.1016/j.jconrel.2022.12.055

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Stereoselective Synthesis of a 4-⍺-Glucoside of Valienamine, Inhibition, and X-Ray Structural Studies Involving a Bacterial Glycoside Hydrolase-Like Enzyme of The GH13 Family

Autor: Si Anshupriya, Thilina D. Jayasinghe, Radhika Thanvi, D.R. Ronning, Steven J. Sucheck

Glycoside hydrolases (GH) are a large family of hydrolytic enzymes found in all domains of life. As such, they control a plethora of normal and pathogenic biological functions. Thus, understanding selective inhibition of GH enzymes at the atomic leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d089c2dff66e4be6a383a923664420c
https://doi.org/10.21203/rs.3.rs-322389/v1