Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Thijs Booiman"'
Autor:
Renée R. C. E. Schreurs, Athanasios Koulis, Thijs Booiman, Brigitte Boeser-Nunnink, Alexandra P. M. Cloherty, Anusca G. Rader, Kharishma S. Patel, Neeltje A. Kootstra, Carla M. S. Ribeiro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Chronic HIV-1 infection is characterized by T-cell dysregulation that is partly restored by antiretroviral therapy. Autophagy is a critical regulator of T-cell function. Here, we demonstrate a protective role for autophagy in HIV-1 disease p
Externí odkaz:
https://doaj.org/article/3c90dc6926bc447289817ab4859f4bfc
Autor:
Zita Kruize, Ad C. van Nuenen, Stan W. van Wijk, Arginell F. Girigorie, Karel A. van Dort, Thijs Booiman, Neeltje A. Kootstra
Publikováno v:
Viruses, Vol 13, Iss 3, p 423 (2021)
Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC). He
Externí odkaz:
https://doaj.org/article/d9addb0636644bda8fd7da4b09037f9c
Publikováno v:
Cell Reports, Vol 13, Iss 9, Pp 1789-1799 (2015)
Human cells express natural antiviral proteins, such as APOBEC3G (A3G), that potently restrict HIV replication. As a counter-defense, HIV encodes the accessory protein Vif, which binds A3G and mediates its proteasomal degradation. Our structural know
Externí odkaz:
https://doaj.org/article/c8379c8d4718457aa9298ce8d5ae9bb6
Autor:
Thijs Booiman, Ferdinand W Wit, Arginell F Girigorie, Irma Maurer, Davide De Francesco, Caroline A Sabin, Agnes M Harskamp, Maria Prins, Claudio Franceschi, Steven G Deeks, Alan Winston, Peter Reiss, Neeltje A Kootstra, Co-morBidity in Relation to Aids (COBRA) Collaboration
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183357 (2017)
HIV-1-positive individuals on successful antiretroviral therapy (ART) are reported to have higher rates of age-associated non-communicable comorbidities (AANCCs). HIV-associated immune dysfunction has been suggested to contribute to increased AANCC r
Externí odkaz:
https://doaj.org/article/7d050fbf6abe4c06b67baa612d0b5cb4
Autor:
Mickaël J Ploquin, Yoann Madec, Armanda Casrouge, Nicolas Huot, Caroline Passaes, Camille Lécuroux, Asma Essat, Faroudy Boufassa, Béatrice Jacquelin, Simon P Jochems, Gaël Petitjean, Mathieu Angin, Kathleen Gärtner, Thalía Garcia-Tellez, Nicolas Noël, Thijs Booiman, Brigitte D Boeser-Nunnink, Pierre Roques, Asier Saez-Cirion, Bruno Vaslin, Nathalie Dereudre-Bosquet, Françoise Barré-Sinoussi, Mathilde Ghislain, Christine Rouzioux, Olivier Lambotte, Matthew L Albert, Cécile Goujard, Neeltje Kootstra, Laurence Meyer, Michaela C Müller-Trutwin
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005774 (2016)
Elevated blood CXCL10/IP-10 levels during primary HIV-1 infection (PHI) were described as an independent marker of rapid disease onset, more robust than peak viremia or CD4 cell nadir. IP-10 enhances the recruitment of CXCR3+ cells, which include maj
Externí odkaz:
https://doaj.org/article/01b4578eaea940188a90b0a4945271a3
Autor:
Thijs Booiman, Vladimir V Loukachov, Karel A van Dort, Angélique B van 't Wout, Neeltje A Kootstra
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144229 (2015)
Transcription of the HIV-1 provirus is regulated by both viral and host proteins and is very important in the context of viral latency. In latently infected cells, viral gene expression is inhibited as a result of the sequestration of host transcript
Externí odkaz:
https://doaj.org/article/5fad737902604a6d9f715af2e1ec1346
Autor:
Eloy Cuadrado, Thijs Booiman, John L van Hamme, Machiel H Jansen, Karel A van Dort, Adeline Vanderver, Gillian I Rice, Yanick J Crow, Neeltje A Kootstra, Taco W Kuijpers
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143613 (2015)
Unlike resting CD4+ T cells, activated CD4+T cells are highly susceptible to infection of human immunodeficiency virus 1 (HIV-1). HIV-1 infects T cells and macrophages without activating the nucleic acid sensors and the anti-viral type I interferon r
Externí odkaz:
https://doaj.org/article/d06d1f73c7034b34910f667c3dc8179b
Autor:
Thijs Booiman, Viviana Cobos Jiménez, Karel A van Dort, Angélique B van 't Wout, Neeltje A Kootstra
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109673 (2014)
BACKGROUND:HIV-1 infected macrophages play a key role in HIV-1 infection. Even during anti-retroviral treatment, macrophages keep producing virus due to suboptimal tissue penetration and reduced efficacy of antiretrovirals. It is therefore of major i
Externí odkaz:
https://doaj.org/article/6a9a382fabd644cf806f66ec2f23b193
Autor:
Sebastiaan M Bol, Thijs Booiman, Daniëlle van Manen, Evelien M Bunnik, Ard I van Sighem, Margit Sieberer, Brigitte Boeser-Nunnink, Frank de Wolf, Hanneke Schuitemaker, Peter Portegies, Neeltje A Kootstra, Angélique B van 't Wout
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30990 (2012)
BACKGROUND: Infection with HIV-1 may result in severe cognitive and motor impairment, referred to as HIV-1-associated dementia (HAD). While its prevalence has dropped significantly in the era of combination antiretroviral therapy, milder neurocogniti
Externí odkaz:
https://doaj.org/article/39162ba0da244103989f1c69d89be247
Autor:
Renée Schreurs, Athanasios Koulis, Thijs Booiman, Brigitte Boeser-Nunnink, Alexandra Cloherty, Anusca Rader, Kharishma Patel, Neeltje Kootstra, Carla Ribeiro
Chronic HIV-1 infection is characterized by T-cell dysregulation that is only partly restored by antiretroviral therapy. Here, we demonstrate a protective role for autophagy in HIV-1 disease pathogenesis. Targeted analysis of genetic variation in cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc637495e5fc5835c4692f70123736be
https://doi.org/10.21203/rs.3.rs-2616340/v1
https://doi.org/10.21203/rs.3.rs-2616340/v1