Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Thijn R Brummelkamp"'
Autor:
Riccardo Mezzadra, Marjolein de Bruijn, Lucas T Jae, Raquel Gomez-Eerland, Anja Duursma, Ferenc A Scheeren, Thijn R Brummelkamp, Ton N Schumacher
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212053 (2019)
Experimental and clinical observations have highlighted the role of cytotoxic T cells in human tumor control. However, the parameters that control tumor cell sensitivity to T cell attack remain incompletely understood. To identify modulators of tumor
Externí odkaz:
https://doaj.org/article/7635229cc987440c80b60faae31cd35d
Autor:
Melinda Ng, Esther Ndungo, Maria E Kaczmarek, Andrew S Herbert, Tabea Binger, Ana I Kuehne, Rohit K Jangra, John A Hawkins, Robert J Gifford, Rohan Biswas, Ann Demogines, Rebekah M James, Meng Yu, Thijn R Brummelkamp, Christian Drosten, Lin-Fa Wang, Jens H Kuhn, Marcel A Müller, John M Dye, Sara L Sawyer, Kartik Chandran
Publikováno v:
eLife, Vol 4 (2015)
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon he
Externí odkaz:
https://doaj.org/article/a4ca56856f3e47a9ba72fff1209120bf
Autor:
Peter Tsvetkov, Marc L Mendillo, Jinghui Zhao, Jan E Carette, Parker H Merrill, Domagoj Cikes, Malini Varadarajan, Ferdy R van Diemen, Josef M Penninger, Alfred L Goldberg, Thijn R Brummelkamp, Sandro Santagata, Susan Lindquist
Publikováno v:
eLife, Vol 4 (2015)
Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome function is vulnerable to environmental insults, cellular protein imbalance and targeted pharmaceuticals. Yet, mechanisms that cells deploy to counteract inhibition o
Externí odkaz:
https://doaj.org/article/ccbe588bb5ce4c2badc9e24644ddeeef
A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-κB.
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70339 (2013)
The development of forward genetic screens in human haploid cells has the potential to transform our understanding of the genetic basis of cellular processes unique to man. So far, this approach has been limited mostly to the identification of genes
Externí odkaz:
https://doaj.org/article/8490b37a67754403b20a2ccd4ac64a23
Autor:
Marcel A T M van Vugt, Alexandra K Gardino, Rune Linding, Gerard J Ostheimer, H Christian Reinhardt, Shao-En Ong, Chris S Tan, Hua Miao, Susan M Keezer, Jeijin Li, Tony Pawson, Timothy A Lewis, Steven A Carr, Stephen J Smerdon, Thijn R Brummelkamp, Michael B Yaffe
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000287 (2010)
DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While activation of DNA damage ch
Externí odkaz:
https://doaj.org/article/4f174f4259f044698e196166a19c278f
Autor:
Lisa Koob, Anoek Friskes, Louise vanBergen, Femke M. Feringa, Bram van denBroek, Emma S. Koeleman, Ellis vanBeek, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, René H. Medema
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1192-1211 (2023)
Faithful and timely repair of DNA double‐strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co‐factor MND1 facilitates the repair of DSBs in somatic cells. We show tha
Externí odkaz:
https://doaj.org/article/e82d5294e0a84e3596d187a3bb227b86
Autor:
Abdelghani Mazouzi, Sarah C. Moser, Federico Abascal, Bram van den Broek, Martin Del Castillo Velasco-Herrera, Ingrid van der Heijden, Maarten Hekkelman, Anne Paulien Drenth, Eline van der Burg, Lona J. Kroese, Kees Jalink, David J. Adams, Jos Jonkers, Thijn R. Brummelkamp
Publikováno v:
Science Advances. 9
DNA interstrand crosslinks (ICLs) pose a major obstacle for DNA replication and transcription if left unrepaired. The cellular response to ICLs requires the coordination of various DNA repair mechanisms. Homologous recombination (HR) intermediates ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e6e7cedd9db10221bdcfd61f019d11d
https://doi.org/10.1126/sciadv.adf4409
https://doi.org/10.1126/sciadv.adf4409
Autor:
Lisa Koob, Anoek Friskes, Louise van Bergen, Femke M. Feringa, Bram van den Broek, Emma S. Koeleman, Ellis van Beek, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, René H. Medema
Publikováno v:
Molecular Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f8432bc6109367b193ccf83421219ee
https://doi.org/10.1002/1878-0261.13448
https://doi.org/10.1002/1878-0261.13448
Autor:
Marianne Boes, Stefan Nierkens, Thijn R. Brummelkamp, Jaap Jan Boelens, Maarten Altelaar, Onno B. Bleijerveld, Elmer Stickel, Rianne Haarsma, Joppe Nieuwenhuis, Lotte Spel
List of used antibodies, plasmids, gRNA sequences and datasets. Figures showing expression data, gene correlations, cell line clonality, screen replicates, and protein expression in neuroblastoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2b3bbf4485a26726704e9603fe9496
https://doi.org/10.1158/0008-5472.22418492.v1
https://doi.org/10.1158/0008-5472.22418492.v1
Autor:
Marianne Boes, Stefan Nierkens, Thijn R. Brummelkamp, Jaap Jan Boelens, Maarten Altelaar, Onno B. Bleijerveld, Elmer Stickel, Rianne Haarsma, Joppe Nieuwenhuis, Lotte Spel
Basemean and fold change scores per indivudual gRNA used in the CRISPR screen resulting in a significant TRUE of FALSE hit in the screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c174cda1170abebb8180b5277a2c1d9
https://doi.org/10.1158/0008-5472.22418489.v1
https://doi.org/10.1158/0008-5472.22418489.v1