Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Thierry T Diagana"'
Autor:
Paul G Ashigbie, Susan Shepherd, Kevin L Steiner, Beatrice Amadi, Natasha Aziz, Ujjini H Manjunatha, Jonathan M Spector, Thierry T Diagana, Paul Kelly
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009057 (2021)
Cryptosporidium is a widely distributed enteric parasite that has an increasingly appreciated pathogenic role, particularly in pediatric diarrhea. While cryptosporidiosis has likely affected humanity for millennia, its recent "emergence" is largely t
Externí odkaz:
https://doaj.org/article/2b0571b14ff849bb96c349c92fc27a13
Autor:
Nicole L Bertschi, Annemarie Voorberg-van der Wel, Anne-Marie Zeeman, Sven Schuierer, Florian Nigsch, Walter Carbone, Judith Knehr, Devendra K Gupta, Sam O Hofman, Nicole van der Werff, Ivonne Nieuwenhuis, Els Klooster, Bart W Faber, Erika L Flannery, Sebastian A Mikolajczak, Vorada Chuenchob, Binesh Shrestha, Martin Beibel, Tewis Bouwmeester, Niwat Kangwanrangsan, Jetsumon Sattabongkot, Thierry T Diagana, Clemens HM Kocken, Guglielmo Roma
Publikováno v:
eLife, Vol 7 (2018)
Relapses of Plasmodium dormant liver hypnozoites compromise malaria eradication efforts. New radical cure drugs are urgently needed, yet the vast gap in knowledge of hypnozoite biology impedes drug discovery. We previously unraveled the transcriptome
Externí odkaz:
https://doaj.org/article/6d1126676c6b4f1ea54e1b0c7ad01e87
Autor:
Srinivasa P S Rao, Suresh B Lakshminarayana, Jan Jiricek, Marcel Kaiser, Ryan Ritchie, Elmarie Myburgh, Frantisek Supek, Tove Tuntland, Advait Nagle, Valentina Molteni, Pascal Mäser, Jeremy C Mottram, Michael P Barrett, Thierry T Diagana
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 28 (2020)
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the
Externí odkaz:
https://doaj.org/article/e5e1e471c0c746d79f9d7063a4a2f672
Autor:
Nelson V. Simwela, W. Armand Guiguemde, Judith Straimer, Clement Regnault, Barbara H. Stokes, Luis E. Tavernelli, Fumiaki Yokokawa, Benjamin Taft, Thierry T. Diagana, Michael P. Barrett, Andrew P. Waters
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Characterizing the mode of action of anti-malarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to
Externí odkaz:
https://doaj.org/article/5bf7e7bb83394a2cb354699274035118
Autor:
Adeline C. Y. Chua, Jessica Jie Ying Ong, Benoit Malleret, Rossarin Suwanarusk, Varakorn Kosaisavee, Anne-Marie Zeeman, Caitlin A. Cooper, Kevin S. W. Tan, Rou Zhang, Bee Huat Tan, Siti Nurdiana Abas, Andy Yip, Anne Elliot, Chester J. Joyner, Jee Sun Cho, Kate Breyer, Szczepan Baran, Amber Lange, Steven P. Maher, François Nosten, Christophe Bodenreider, Bryan K. S. Yeung, Dominique Mazier, Mary R. Galinski, Nathalie Dereuddre-Bosquet, Roger Le Grand, Clemens H. M. Kocken, Laurent Rénia, Dennis E. Kyle, Thierry T. Diagana, Georges Snounou, Bruce Russell, Pablo Bifani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Present understanding of Plasmodium vivax biology is hampered by its inability to grow in vitro. Here, the authors developed an in vitro culture of its simian counterpart, P. cynomolgi, which shares morphological and phenotypic similarities with P. v
Externí odkaz:
https://doaj.org/article/68f08622b7b941e08fb8d5ecab44264a
Autor:
Srinivasa P.S. Rao, Ujjini H. Manjunatha, Sebastian Mikolajczak, Paul G. Ashigbie, Thierry T. Diagana
Publikováno v:
Trends in Parasitology. 39:260-271
Autor:
Dennis C. Koester, Vanessa M. Marx, Sarah Williams, Jan Jiricek, Maxime Dauphinais, Olivier René, Sarah L. Miller, Lei Zhang, Debjani Patra, Yen-Liang Chen, Harry Cheung, Jonathan Gable, Suresh B. Lakshminarayana, Colin Osborne, Jean-Rene Galarneau, Upendra Kulkarni, Wendy Richmond, Angela Bretz, Linda Xiao, Frantisek Supek, Christian Wiesmann, Srinivas Honnappa, Celine Be, Pascal Mäser, Marcel Kaiser, Ryan Ritchie, Michael P. Barrett, Thierry T. Diagana, Christopher Sarko, Srinivasa P. S. Rao
Publikováno v:
Journal of Medicinal Chemistry. 65:11776-11787
Human African Trypanosomiasis (HAT) is a vector-borne disease caused by kinetoplastid parasites of the Trypanosoma genus. The disease proceeds in two stages, with a hemolymphatic blood stage and a meningo-encephalic brain stage. In the latter stage,
Autor:
Nelson V. Simwela, W. Armand Guiguemde, Judith Straimer, Clement Regnault, Fumiaki Yokokawa, Benjamin Taft, Thierry T. Diagana, Michael P. Barrett, Andrew P. Waters
Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4852ff7d6867de78ef13794bc197ef3d
https://doi.org/10.1101/2022.10.03.510714
https://doi.org/10.1101/2022.10.03.510714
Autor:
Gabriel Mitchell, Guglielmo Roma, Annemarie Voorberg-van der Wel, Martin Beibel, Anne-Marie Zeeman, Sven Schuierer, Laura Torres, Erika L Flannery, Clemens HM Kocken, Sebastian A. Mikolajczak, Thierry T. Diagana
Publikováno v:
Malaria journal. 21(1)
Background The zoonotic simian parasite Plasmodium cynomolgi develops into replicating schizonts and dormant hypnozoites during the infection of hepatocytes and is used as a model organism to study relapsing malaria. The transcriptional profiling of
Autor:
Ujjini H. Manjunatha, Natko Nuber, Cynthia L. Chappell, Wilbur H. Chen, Rajiv S. Jumani, Jay Parthiban Lakshman, Richa Chandra, Natasha Aziz, Dean Wetty, Thierry T. Diagana, Johanne Blais, Hanns-Christian Tillmann, Florencia Segal, Christian Ostermeier
Publikováno v:
ACS Infectious Diseases
Cryptosporidiosis is a leading cause of moderate-to-severe diarrhea in low- and middle-income countries, responsible for high mortality in children younger than two years of age, and it is also strongly associated with childhood malnutrition and grow