Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Thierry Schmitz"'
Autor:
Vjera Grabovac, Martin H. Hoffer, Andreas Bernkop-Schnürch, Thomas F. Palmberger, Thierry Schmitz
Publikováno v:
International Journal of Pharmaceutics. 347:79-85
The aim of the present study was to synthesize and characterize a novel thiolated polymer by covalent attachment of N-acetyl cysteine to chitosan. The obtained conjugate was characterized in vitro by quantification of immobilized thiol groups and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5265e8f3841f48f2619bfb8fdbb2ad
https://doi.org/10.1016/j.ijpharm.2007.06.040
https://doi.org/10.1016/j.ijpharm.2007.06.040
Publikováno v:
Drug Delivery. 15:245-252
This study evaluated three chitosan-N-acetyl cysteine (CAC) conjugates of increasing molecular mass as a valuable tool to improve the absorption of drugs by assessing its permeation enhancing effect regarding the active P-gp substrate rhodamine-123 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e20b183721110482dbd9896db8af50
https://doi.org/10.1080/10717540802006708
https://doi.org/10.1080/10717540802006708
Autor:
Andreas Bernkop-Schnürch, Christine Vauthier, Gilles Ponchel, Thierry Schmitz, Irene Bravo-Osuna
Publikováno v:
International Journal of Pharmaceutics. 316:170-175
The aim of the present work was to investigate the use of thiolated chitosan in the development of polysaccharide-coated nanoparticles in order to confer specific functionality to the system. After chemical modification of commercial and hydrolysed c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ce54d38a0edf5aae386d84c7929a81
https://doi.org/10.1016/j.ijpharm.2006.02.037
https://doi.org/10.1016/j.ijpharm.2006.02.037
Publikováno v:
Journal of Drug Targeting. 14:117-125
In oral peptide delivery, the gap between convenient administration and low blood concentration has to be minimized. We found that oral peptide drugs have not only to pass the various commonly known barriers encountered with the gastrointestinal trac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86743c78cf3952f33357c8d030456d5e
https://doi.org/10.1080/10611860600647967
https://doi.org/10.1080/10611860600647967
Publikováno v:
Amino Acids. 30:35-42
To date, the majority of therapeutic peptides and proteins have to be administered via parenteral routes, which are painful and inconvenient. In order to gain sufficient high blood concentrations after oral application, various barriers in the gastro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826d17e141d6ab258f60caab9cd4ef01
https://doi.org/10.1007/s00726-005-0241-6
https://doi.org/10.1007/s00726-005-0241-6
Publikováno v:
Journal of Pharmaceutical Sciences. 94:966-973
Low molecular weight heparin (LMWH) is an agent of choice in the anti-coagulant therapy and prophylaxis of thrombosis and coronary syndromes. However, the therapeutic use is partially limited due to a poor oral bioavailability. It was therefore the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563bd662fdc5bcd2020d4e5211e89c9a
https://doi.org/10.1002/jps.20311
https://doi.org/10.1002/jps.20311
Publikováno v:
Current drug metabolism. 8(5)
To date, the majority of therapeutic peptides and proteins have to be administered via parenteral routes, which are painful and inconvenient. Consequently, "injectable-to-oral-conversions" are highly on demand. Apart from a poor membrane uptake, howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d45085a063aa12c3d678b99b69a0ece
https://pubmed.ncbi.nlm.nih.gov/17584022
https://pubmed.ncbi.nlm.nih.gov/17584022
Publikováno v:
Pharmaceutical research. 24(5)
The purpose of this study was to evaluate an effect of the proteolytic enzyme papain on permeation of low molecular weight heparin (LMWH) in vitro and in vivo.In vitro permeation studies were performed using rat small intestine as permeation barrier.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d0ace244f9287f15451e94f4556249
https://pubmed.ncbi.nlm.nih.gov/17372680
https://pubmed.ncbi.nlm.nih.gov/17372680
Autor:
Andreas Bernkop-Schnürch, Hong-Lei Huang, Thierry Schmitz, Martin Werle, Alexander Wentzel, Harald Kolmar
Publikováno v:
Journal of drug targeting. 14(3)
Within this study, the potential of three clinically relevant microproteins (SE-AG-AZ, SE-EM and SE-EP) with cystine-knot architecture as pharmacophoric scaffolds for oral peptide delivery was investigated. Cystine-knot microproteins (CKM) were analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d8e57e81e47d7a6461d5e173b0732b
https://pubmed.ncbi.nlm.nih.gov/16753827
https://pubmed.ncbi.nlm.nih.gov/16753827
Autor:
Thierry Schmitz, Andreas Bernkop-Schnürch, Christine Vauthier, Brigitta Loretz, Irene Bravo-Osuna, Gilles Ponchel
Publikováno v:
Biomaterials. 28(3)
Chitosan-thiobutylamidine was developed and evaluated as a novel tool for gene delivery. The conjugate, displaying 299.1+/-11.5 micromol free thiol groups per gram polymer, formed coacervates with pDNA at a mean size of 125 nm and a zeta potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6184cb03aba30d17f49716d97ed6bf
https://pubmed.ncbi.nlm.nih.gov/16979757
https://pubmed.ncbi.nlm.nih.gov/16979757