Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Thierry SOLDATI"'
Autor:
Jahn Nitschke, Robin Huber, Stefania Vossio, Dimitri Moreau, Laurence Marcourt, Katia Gindro, Emerson F. Queiroz, Thierry Soldati, Nabil Hanna
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionMycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, remains a serious threat to human health worldwide and the quest for new anti-tubercular drugs is an enduring and demanding journey. Natural products (NPs) have played
Externí odkaz:
https://doaj.org/article/448031e5d6664ed2942a9703ecb14984
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/798af471a889457ca7be178117723188
Autor:
Louise H. Lefrançois, Jahn Nitschke, Huihai Wu, Gaël Panis, Julien Prados, Rachel E. Butler, Tom A. Mendum, Nabil Hanna, Graham R. Stewart, Thierry Soldati
Publikováno v:
mSystems, Vol 9, Iss 2 (2024)
ABSTRACTTuberculosis remains the most pervasive infectious disease and the recent emergence of drug-resistant strains emphasizes the need for more efficient drug treatments. A key feature of pathogenesis, conserved between the human pathogen Mycobact
Externí odkaz:
https://doaj.org/article/6f8ef12fa85142f6917fe6f2d44a0b6b
Autor:
Olivier Auguste Kirchhoffer, Jahn Nitschke, Pierre-Marie Allard, Laurence Marcourt, Bruno David, Antonio Grondin, Nabil Hanna, Emerson Ferreira Queiroz, Thierry Soldati, Jean-Luc Wolfender
Publikováno v:
Frontiers in Natural Products, Vol 2 (2023)
Antibiotics resistance is a clear threat to the future of current tuberculosis treatments like rifampicin, prompting the need for new treatment options in this field. While plants can offer a plethora of chemical diversity in their constitutive natur
Externí odkaz:
https://doaj.org/article/84f927e29b8e4a988111fcf402dc5647
Publikováno v:
eLife, Vol 12 (2023)
Cells are perpetually challenged by pathogens, protein aggregates or chemicals, that induce plasma membrane or endolysosomal compartments damage. This severe stress is recognised and controlled by the endosomal sorting complex required for transport
Externí odkaz:
https://doaj.org/article/99188199715a410ab3beac5b1238c28e
Autor:
Estelle Ifrid, Hajer Ouertatani-Sakouhi, Tania Jauslin, Sebastien Kicka, Gianpaolo Chiriano, Christopher F. Harrison, Hubert Hilbi, Leonardo Scapozza, Thierry Soldati, Pierre Cosson
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Klebsiella pneumoniae is the causative agent of a variety of severe infections. Many K. pneumoniae strains are resistant to multiple antibiotics, and this situation creates a need for new antibacterial molecules. K. pneumoniae pathogenicity relies la
Externí odkaz:
https://doaj.org/article/f543c1cb698447c8b1402b476d0f6c60
Autor:
Nabil Hanna, Hendrik Koliwer-Brandl, Louise H. Lefrançois, Vera Kalinina, Elena Cardenal-Muñoz, Joddy Appiah, Florence Leuba, Aurélie Gueho, Hubert Hilbi, Thierry Soldati, Caroline Barisch
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Microelements are essential for the function of the innate immune system. A deficiency in zinc or copper results in an increased susceptibility to bacterial infections.
Externí odkaz:
https://doaj.org/article/39a95568039a4b7dacf1f43313be79d2
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT The human-pathogenic fungus Aspergillus fumigatus is a ubiquitous saprophyte that causes fatal lung infections in immunocompromised individuals. Following inhalation, conidia are ingested by innate immune cells and can arrest phagolysosome m
Externí odkaz:
https://doaj.org/article/c29715319d5e41c79bc424f8f9fee853
Autor:
Otmane Lamrabet, Astrid Melotti, Frédéric Burdet, Nabil Hanna, Jackie Perrin, Jahn Nitschke, Marco Pagni, Hubert Hilbi, Thierry Soldati, Pierre Cosson
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Dictyostelium discoideum amoebae feed by ingesting bacteria, then killing them in phagosomes. Ingestion and killing of different bacteria have been shown to rely on largely different molecular mechanisms. One would thus expect that D. discoideum adap
Externí odkaz:
https://doaj.org/article/fff77f7db321436a87f6ff4d8e1735f8
Autor:
Nabil Hanna, Sébastien Kicka, Gianpaolo Chiriano, Christopher Harrison, Hajer Ouertatani Sakouhi, Valentin Trofimov, Agata Kranjc, Jahn Nitschke, Marco Pagni, Pierre Cosson, Hubert Hilbi, Leonardo Scapozza, Thierry Soldati
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Tubercular Mycobacteria and Legionella pneumophila are the causative agents of potentially fatal respiratory diseases due to their intrinsic pathogenesis but also due to the emergence of antibiotic resistance that limits treatment options. The aim of
Externí odkaz:
https://doaj.org/article/bcff22bba1b245feb81d334c5cb170c5