Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Thierry O. Fischmann"'
Autor:
Essam Metwally, Victor Mak, Aileen Soriano, Matthias Zebisch, H. Leonardo Silvestre, Paul A. McEwan, Grigori Ermakov, Maribel Beaumont, Paul Tawa, John J. Barker, Rose Yen, Akash Patel, Yeon-Hee Lim, David Healy, Jennifer Hanisak, Alan C. Cheng, Tom Greshock, Thierry O. Fischmann
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract cGMP-dependent protein kinase I-α (PKG1α) is a target for pulmonary arterial hypertension due to its role in the regulation of smooth muscle function. While most work has focused on regulation of cGMP turnover, we recently described severa
Externí odkaz:
https://doaj.org/article/35e2c7e8e424458aafb60de67b006cea
Autor:
Victoria A. Kleiner, Thierry O. Fischmann, John A. Howe, Douglas C. Beshore, Michael J. Eddins, Yan Hou, Todd Mayhood, Daniel Klein, Debbie D. Nahas, Bob J. Lucas, He Xi, Edward Murray, Daphne Y. Ma, Krista Getty, Rachel Fearns
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA viruses responsible for severe respiratory infections and resulting disease in infants, elderly, and immunocompromised adults1–3. Therapeutic small molecule
Externí odkaz:
https://doaj.org/article/b774cd14df994f13b41ff196588a5489
Autor:
Lars Guelen, Thierry O Fischmann, Jerelyn Wong, Smita Mauze, Marco Guadagnoli, Nikolina Bąbała, Jozef Wagenaars, Veronica Juan, David Rosen, Winnie Prosise, Maurice Habraken, Imke Lodewijks, Danling Gu, Judith Stammen-Vogelzangs, Ying Yu, Jeanne Baker, David Lutje Hulsik, Lilian Driessen-Engels, Dan Malashock, Joost Kreijtz, Astrid Bertens, Evert de Vries, Astrid Bovens, Arne Bramer, Yiwei Zhang, Richard Wnek, Sean Troth, Elliot Chartash, Konstantin Dobrenkov, Svetlana Sadekova, Andrea van Elsas, Jason K Cheung, Laurence Fayadat-Dilman, Jannie Borst, Amy M Beebe, Hans Van Eenennaam
Publikováno v:
Journal for ImmunoTherapy of Cancer, 10(9). BMJ PUBLISHING GROUP
BackgroundImmune checkpoint inhibitors (ICI) have radically changed cancer therapy, but most patients with cancer are unresponsive or relapse after treatment. MK-5890 is a CD27 agonist antibody intended to complement ICI therapy. CD27 is a member of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e2a5657834d447f836b811d356fb97
https://doi.org/10.1136/jitc-2022-005049
https://doi.org/10.1136/jitc-2022-005049
Autor:
Jiaqiang Cai, Jiayi Xu, Ying-Duo Gao, Wang James J-S, Deodial Guiadeen, Wensheng Yu, Arto D. Krikorian, Joseph A. Kozlowski, Jie Zhang-Hoover, Hao Wu, Sobhana Babu Boga, Jeremy Presland, Chad Bennett, Xiaolei Gao, Charles G. Garlisi, Kevin M. Maloney, Shilan Liu, My Sam Mansueto, Joseph Kelly, Abdul-Basit Alhassan, Alexandra Hicks, Rajan Anand, Jian Liu, Erica Leccese, Philip E. Brandish, Ronald M. Kim, Peter Stivers, Joseph L. Duffy, Sriram Tyagarajan, Thierry O. Fischmann, Oleg Selyutin, Younong Yu, Ian Knemeyer, Zangwei Xu, Chundao Yang
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(17)
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition, and for the treatment of B cell related diseases. Many BTK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da5ce66383962022d93e832cf2c0143
https://pubmed.ncbi.nlm.nih.gov/32738973
https://pubmed.ncbi.nlm.nih.gov/32738973
Autor:
Denarra Simmons, Giovanna Scapin, Chakravarthy Nachu Narasimhan, Paul Reichert, Corey Strickland, Ray Polniak, Erika Walsh, Xiaoyu Yang, Winifred W. Prosise, Wendy Benjamin, Thierry O. Fischmann, Johnathan Welch, Daya Patel, April Spinale
Publikováno v:
NPJ Microgravity
npj Microgravity, Vol 5, Iss 1, Pp 1-8 (2019)
npj Microgravity, Vol 5, Iss 1, Pp 1-8 (2019)
Crystallization processes have been widely used in the pharmaceutical industry for the manufacture, storage, and delivery of small-molecule and small protein therapeutics. However, the identification of crystallization processes for biologics, partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb45bdad7acc4ef24653373a04bc34e
http://europepmc.org/articles/PMC6889310
http://europepmc.org/articles/PMC6889310
Autor:
Deodial Guiadeen, Shilan Liu, Jian Liu, Charles G. Garlisi, Arto D. Krikorian, Ronald M. Kim, Ying-Duo Gao, Peter Stivers, Hugh Y. Zhu, Alan B. Cooper, Rajan Anand, Philip E. Brandish, Younong Yu, Nathan Bays, Jiaqiang Cai, Ian Knemeyer, Erica Leccese, Zangwei Xu, Kevin M. Maloney, Alexandra Hicks, Sobhana Babu Boga, Chundao Yang, Joseph A. Kozlowski, My Sam Mansueto, Hao Wu, Thierry O. Fischmann, Desai Jagdish A, Jeremy Presland, Abdul-Basit Alhassan, Xiaolei Gao, Wang James J-S
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3939-3943
8-Amino-imidazo[1,5- a ]pyrazine-based Bruton’s tyrosine kinase (BTK) inhibitors, such as 6 , exhibited potent inhibition of BTK but required improvements in both kinase and hERG selectivity (Liu et al., 2016; Gao et al., 2017). In an effort to mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374dfa7e3c822671c1df7ad53a01c129
https://doi.org/10.1016/j.bmcl.2017.03.040
https://doi.org/10.1016/j.bmcl.2017.03.040
Autor:
Laurence Fayadat-Dilman, Thierry O. Fischmann, Jeanne Baker, Corey Strickland, Alan C. Cheng, Mark Hsieh, Makiko Uchida, Gopalan Raghunathan, Carl Mieczkowski
Publikováno v:
Antibodies
Volume 10
Issue 1
Antibodies, Vol 10, Iss 8, p 8 (2021)
Volume 10
Issue 1
Antibodies, Vol 10, Iss 8, p 8 (2021)
Reversible antibody self-association, while having major developability and therapeutic implications, is not fully understood or readily predictable and correctable. For a strongly self-associating humanized mAb variant, resulting in unacceptable vis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3ff6da0d83838dcaff910ec229a90b
https://doi.org/10.3390/antib10010008
https://doi.org/10.3390/antib10010008
Autor:
Artjohn Villafania, Christopher M. Barbieri, Terry Roemer, Hao Wang, Thierry O. Fischmann, Li Xiao, Rumin Zhang, Haifeng Tang, John A. Howe
Publikováno v:
RNA Biology
Bacterial riboswitches are non-coding RNA structural elements that direct gene expression in numerous metabolic pathways. The key regulatory roles of riboswitches, and the urgent need for new classes of antibiotics to treat multi-drug resistant bacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700734b4e5e5f087bcf3dc756a22a15c
https://doi.org/10.1080/15476286.2016.1216304
https://doi.org/10.1080/15476286.2016.1216304
Autor:
John A. Howe, Julja Burchard, Gabriel Mercado, Graham Smith, Daniel J. Klein, Margaret T. Butko, Scott S. Walker, Thierry O. Fischmann, Corey Strickland, Hai-Young Kim, Elliott B. Nickbarg, Alan Hruza, Ali Nahvi, Noreen F. Rizvi, Matthew Richards, Mark A. McCoy, Peter J. Dandliker, Chad Chamberlin, Peter Saradjian
Publikováno v:
ACS chemical biology. 13(3)
Recent advances in understanding the relevance of noncoding RNA (ncRNA) to disease have increased interest in drugging ncRNA with small molecules. The recent discovery of ribocil, a structurally distinct synthetic mimic of the natural ligand of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b49ae92950caad1b013beb70995111b
https://pubmed.ncbi.nlm.nih.gov/29412640
https://pubmed.ncbi.nlm.nih.gov/29412640
Autor:
Artjohn Villafania, Hao Wang, Li Xiao, Charles Gill, Payal R. Sheth, John Cummings, Terry Roemer, Andrew Galgoci, Charles G. Garlisi, Rumin Zhang, Carl J. Balibar, Christopher M. Barbieri, Juliana C. Malinverni, Nicholas Murgolo, Ellen Xia, Brad Sherborne, Haifeng Tang, Michael A. Plotkin, Paul Zuck, Daniel Riley, Scott S. Walker, Ali Nahvi, Paul Mann, Diane Rindgen, Ronald E. Painter, John A. Howe, Jin Wu, Todd Mayhood, Donna Carr, Reynalda K. de Jesus, Weidong Pan, Thierry O. Fischmann
Publikováno v:
Nature. 526:672-677
Riboswitches are non-coding RNA structures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or ion, to regulate gene expression. As such, riboswitches serve as a novel, yet largely unexploited, class of emerging d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9370295b7c3eaaa0b0cae549c30d113
https://doi.org/10.1038/nature15542
https://doi.org/10.1038/nature15542