Use of a Th1 Stimulator Adjuvant for Vaccination against Neospora caninum Infection in the Pregnant Mouse Model

Autor: Denis Grandgirard, Stephen L. Leib, Andrew Hemphill, Thierry Monney

Publikováno v: Pathogens, Vol 2, Iss 2, Pp 193-208 (2013)

Vertical transmission from an infected cow to its fetus accounts for the vast majority of new Neospora caninum infections in cattle. A vaccine composed of a chimeric antigen named recNcMIC3-1-R, based on predicted immunogenic domains of the two micro

Externí odkaz: https://doaj.org/article/551ff08850b848e594fbe36d9daef9dd

Pre-clinical characterization of ISB 1342, a CD38xCD3 T-cell engager for relapsed/refractory multiple myeloma

Autor: Blandine Pouleau, Carole Estoppey, Perrine Suere, Emilie Nallet, Amélie Laurendon, Thierry Monney, Daniela Pais Ferreira, Adam Drake, Laura Carretero-Iglesia, Julie Macoin, Jeremy Berret, Maria Pihlgren, Marie-Agnes Doucey, Girish S Gudi, Vinu Menon, Venkatesha Udupa, Abhishek Maiti, Gautam Borthakur, Ankita Srivastava, Stanislas Blein, Lamine Mbow, Thomas Matthes, Zeynep Kaya, Claire M Edwards, James R Edwards, Emmanuelle Menoret, Charlotte Kervoelen, Catherine Pellat-Deceunynck, Philippe Moreau, Eugene Alexander Zhukovsky, Mario Perro, Myriam Chimen

Publikováno v: Blood Journal.

Whilst treatment of multiple myeloma (MM) with daratumumab significantly extend patient lifespan, resistance to therapy is inevitable. ISB 1342 was designed to target MM cells from patients with relapsed/refractory MM (r/rMM) displaying lower sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4fe89bd3308d6688a193e59e795c418
https://doi.org/10.1182/blood.2022019451

Abstract 2903: ISB 1442, a first-in-class CD38 and CD47 bispecific antibody innate cell modulator for the treatment of CD38+ malignancies

Autor: Stefano Sammicheli, Camille Grandclement, Elie Dheilly, Maria Panagopoulou, Evangelia Martini, Perrine Suere, Blandine Pouleau, Carole Estoppey, Julia Frei, Jeremy Loyau, Thierry Monney, Adam Drake, Alain Rubod, Marie Agnes Doucey, Vinu Menon, Venkatesha Udupa, Sunitha GN, Daniel Rasmussen, Jeppe Koch Olsen, Roberto Gionannini, Girish Gudi, Ankita Srivastava, Cyril Konto, Mario Perro

Publikováno v: Cancer Research. 82:2903-2903

ISB 1442 is a fully human bispecific antibody (BsAb) using BEAT (Bispecific Engagement by Antibodies based on the T-cell receptor) platform to target CD38 and CD47 as treatment for CD38+ malignancies, including multiple myeloma (MM). ISB 1442 is desi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::017b7033934a6e47259004da3916dfc8
https://doi.org/10.1158/1538-7445.am2022-2903

Immunoglobulin domain interface exchange as a platform technology for the generation of Fc heterodimers and bispecific antibodies

Autor: Stanislas Blein, Emelie Svensson, Florence Bourquin, Thierry Monney, Paul Wassmann, Sunitha Gn, Romain Ollier, Cian Stutz, Darko Skegro

Publikováno v: The Journal of Biological Chemistry

Bispecific antibodies (bsAbs) are of significant importance to the development of novel antibody-based therapies, and heavy chain (Hc) heterodimers represent a major class of bispecific drug candidates. Current technologies for the generation of Hc h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39da5f0b44eab166109a50f9f4732c62
https://pubmed.ncbi.nlm.nih.gov/28450393

Differential Effects on Survival, Humoral Immune Responses and Brain Lesions in Inbred BALB/C, CBA/CA, and C57BL/6 Mice Experimentally Infected with Neospora caninum Tachyzoites

Autor: Tanja G. T. Mols-Vorstermans, Andrew Hemphill, Dick Schaap, Eveline Boerhout, Thierry Monney

Publikováno v: ISRN Parasitology
Mols-Vorstermans, Tanja; Hemphill, Andrew; Monney, Thierry; Schaap, Dick; Boerhout, Eveline (2013). Differential Effects on Survival, Humoral Immune Responses and Brain Lesions in Inbred BALB/C, CBA/CA, and C57BL/6 Mice Experimentally Infected with Neospora caninum Tachyzoites. ISRN Parasitology, 2013, pp. 1-11. Hindawi 10.5402/2013/830980

C57BL/6, BALB/c, and CBA/Ca mouse strains with different MHC-I haplotypes were compared with respect to susceptibility to Neospora caninum infection. Groups of 5 mice received , , or tachyzoites of the NC-Liverpool isolate by intraperitoneal injectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5340e4df355f18c8c87e3935f184649
https://doi.org/10.5402/2013/830980