Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Thierry Lomberget"'
Autor:
Alexandre Bancet, Rita Frem, Florian Jeanneret, Angélique Mularoni, Pauline Bazelle, Caroline Roelants, Jean-Guy Delcros, Jean-François Guichou, Catherine Pillet, Isabelle Coste, Toufic Renno, Christophe Battail, Claude Cochet, Thierry Lomberget, Odile Filhol, Isabelle Krimm
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108903- (2024)
Summary: Although the involvement of protein kinase CK2 in cancer is well-documented, there is a need for selective CK2 inhibitors suitable for investigating CK2 specific roles in cancer-related biological pathways and further exploring its therapeut
Externí odkaz:
https://doaj.org/article/41eefb09154c47d1a837761d86fb8080
Autor:
Ghina Alameh, Agnès Emptoz-Bonneton, Marc Rolland de Ravel, Eva L. Matera, Elisabeth Mappus, Patrick Balaguer, Luc Rocheblave, Thierry Lomberget, Charles Dumontet, Marc Le Borgne, Michel Pugeat, Catherine Grenot, Claude Y. Cuilleron
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 684-691 (2019)
Synthetic progesterone and 5α/β-pregnane-3,20-dione derivatives were evaluated as in vitro and in vivo modulators of multidrug-resistance (MDR) using two P-gp-expressing human cell lines, the non-steroidogenic K562/R7 erythroleukaemia cells and the
Externí odkaz:
https://doaj.org/article/55b0290ee7904a11adb07838554e6862
Autor:
Benoît Bestgen, Zakia Belaid-Choucair, Thierry Lomberget, Marc Le Borgne, Odile Filhol, Claude Cochet
Publikováno v:
Pharmaceuticals, Vol 10, Iss 1, p 16 (2017)
Protein kinase CK2 is a tetrameric holoenzyme composed of two catalytic (α and/or α’) subunits and two regulatory (β) subunits. Crystallographic data paired with fluorescence imaging techniques have suggested that the formation of the CK2 holoen
Externí odkaz:
https://doaj.org/article/0f8d4e0a389a48888fcf88e77cc213fa
Autor:
Alexandre Bancet, Rita Frem, Florian Jeanneret, Angélique Mularoni, Pauline Bazelle, Caroline Roelants, Jean-Guy Delcros, Jean-François Guichou, Catherine Pillet, Isabelle Coste, Toufic Renno, Christophe Battail, Claude Cochet, Thierry Lomberget, Odile Filhol, Isabelle Krimm
Although the involvement of protein kinase CK2 in cancer is well-documented, there is a need for selective CK2 inhibitors suitable for investigating CK2 specific roles in cancer-related biological pathways and further explore its therapeutic potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecc80309dd80d08e01af158a30d3d7bc
https://doi.org/10.1101/2022.12.16.520736
https://doi.org/10.1101/2022.12.16.520736
Autor:
Sylvie Radix, François Hallé, Zahia Mahiout, Amélie Teissonnière, Grégoire Bouchez, Ludovic Auberger, Roland Barret, Thierry Lomberget
Publikováno v:
Helvetica Chimica Acta. 105
Autor:
Mathilde Briday, François Hallé, Lauriane Lecoq, Sylvie Radix, Juliette Martin, Roland Montserret, Marie Dujardin, Marie-Laure Fogeron, Michael Nassal, Beat H. Meier, Thierry Lomberget, Anja Böckmann
Publikováno v:
Chemical Science, 13 (30)
Hepatitis B virus (HBV) is a small enveloped retrotranscribing DNA virus and an important human pathogen. Its capsid-forming core protein (Cp) features a hydrophobic pocket proposed to be central notably in capsid envelopment. Indeed, mutations in an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbe6ac2592fec220726c542109d7fc6
Autor:
Alexandre Bancet, Claire Raingeval, Thierry Lomberget, Jean-François Guichou, Isabelle Krimm, Marc Le Borgne
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (20), pp.11420-11435. ⟨10.1021/acs.jmedchem.0c00242⟩
Journal of Medicinal Chemistry, 2020, 63 (20), pp.11420-11435. ⟨10.1021/acs.jmedchem.0c00242⟩
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (20), pp.11420-11435. ⟨10.1021/acs.jmedchem.0c00242⟩
Journal of Medicinal Chemistry, 2020, 63 (20), pp.11420-11435. ⟨10.1021/acs.jmedchem.0c00242⟩
International audience; Fragment-based drug discovery is a strategy widely used in both academia and pharmaceutical companies to generate small-molecule protein inhibitors and drug candidates. Among the approaches reported in the literature (growing,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c05ee129f575cbff72f7c36846be933
https://hal.archives-ouvertes.fr/hal-03045139
https://hal.archives-ouvertes.fr/hal-03045139
Autor:
Ruben Abagyan, Renaud Prudent, Thierry Lomberget, Céline F. Sautel, Béatrice Laudet, Matthias Engel, Isabelle Krimm, Odile Filhol, Marc Le Borgne, Irina Kufareva, Mohamed Ettaoussi, Claude Cochet, Paul Brear, Benoit Bestgen, Virginie Moucadel
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-52141-5⟩
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.15893. ⟨10.1038/s41598-019-52141-5⟩
Scientific Reports, 2019, 9 (1), pp.15893. ⟨10.1038/s41598-019-52141-5⟩
Scientific reports, vol 9, iss 1
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-52141-5⟩
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.15893. ⟨10.1038/s41598-019-52141-5⟩
Scientific Reports, 2019, 9 (1), pp.15893. ⟨10.1038/s41598-019-52141-5⟩
Scientific reports, vol 9, iss 1
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by peptides to achieve f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb42963b4bb31b7a9a23b98e865c8e28
https://hal.archives-ouvertes.fr/hal-02466039
https://hal.archives-ouvertes.fr/hal-02466039
Autor:
Thierry Lomberget, Jordane Preto, Abdelfattah Faouzi, Cong Viet Do, Alexandre Arnaud, Marion Verrière, Caroline Barette, Alexandre Bancet, Marie-Odile Fauvarque, Roland Barret, Zineb Bousfiha, Amaury Farce, Lars Petter Jordheim, Thi Thanh Binh Nguyen
Publikováno v:
European Journal of Medicinal Chemistry. 215:113275
Combretastatin A-4 inspired heterocyclic derivatives were synthesized and evaluated for their biological activities on tubulin polymerization and cell proliferation. Among the 19 described sulfur-containing compounds, derivatives (Z)-4h and (Z)-4j ex
Autor:
Isabelle Krimm, Claude Cochet, Irina Kufareva, Ahmed A. M. Kamal, Thierry Lomberget, Benoit Bestgen, Rolf W. Hartmann, Ruben Abagyan, Matthias Engel, Wei-Guang Seetoh, Chris Abell, Marc Le Borgne
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (4), pp.1803-1816. ⟨10.1021/acs.jmedchem.8b01766⟩
Journal of Medicinal Chemistry, 2019, 62 (4), pp.1803-1816. ⟨10.1021/acs.jmedchem.8b01766⟩
J Med Chem
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (4), pp.1803-1816. ⟨10.1021/acs.jmedchem.8b01766⟩
Journal of Medicinal Chemistry, 2019, 62 (4), pp.1803-1816. ⟨10.1021/acs.jmedchem.8b01766⟩
J Med Chem
CK2 is a ubiquitous Ser/Thr protein kinase involved in the control of various signaling pathways and is known to be constitutively active. In the present study, we identified aryl 2-aminothiazoles as a novel class of CK2 inhibitors, which displayed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066beaa02f97df972d46a5674a216934
https://hal.archives-ouvertes.fr/hal-02004986
https://hal.archives-ouvertes.fr/hal-02004986