Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Thierry Lave"'
Publikováno v:
New Insights into Toxicity and Drug Testing
Physiologically based pharmacokinetic (PBPK) models differ from classical PK models in that they include specific compartments for tissues involved in exposure, toxicity, biotransforma‐ tion and clearance processes connected by blood flow (Figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3415b6c7e255ea1504291b9f6226d133
http://www.intechopen.com/articles/show/title/physiologically-based-pharmacokinetic-modeling-a-tool-for-understanding-admet-properties-and-extrapo
http://www.intechopen.com/articles/show/title/physiologically-based-pharmacokinetic-modeling-a-tool-for-understanding-admet-properties-and-extrapo
Publikováno v:
Clinical Drug Investigation. 9:150-155
The objective of this study was to investigate the presence of stereoselective processes in the pharmacokinetics and metabolism of tertatolol in humans, using urinary excretion data. Six healthy male volunteers were given single 5mg oral doses of (+,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a582861192a6458469573fc5caa9b20
https://doi.org/10.2165/00044011-199509030-00003
https://doi.org/10.2165/00044011-199509030-00003
Autor:
Patrick F. Smith, Micaela B. Reddy, Sophie Le Pogam, Peter N. Morcos, Thierry Lave, Ying Ou, Karl Frank
Publikováno v:
Antimicrobial agents and chemotherapy. 56(6)
This analysis was conducted to determine whether the hepatitis C virus (HCV) viral kinetics (VK) model can predict viral load (VL) decreases for nonnucleoside polymerase inhibitors (NNPolIs) and protease inhibitors (PIs) after 3-day monotherapy studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15d862f28cebfb9adabfbc00a6a2991
https://pubmed.ncbi.nlm.nih.gov/22470110
https://pubmed.ncbi.nlm.nih.gov/22470110
Autor:
Andrzej M. Kierzek, Timothy P. Hickling, Isabel Figueroa, J. Cory Kalvass, Marjoleen Nijsen, Krithika Mohan, Geertruida M. Veldman, Akihiro Yamada, Hiroyuki Sayama, Sachiko Yokoo, Abhishek Gulati, Renu S. Dhanikula, Jochem Gokemeijer, Tarek A. Leil, Craig J. Thalhauser, Mario Giorgi, Maciej J. Swat, Vijayalakshmi Chelliah, Ben G. Small, Neil Benson, Michael Walker, Kapil Gadkar, Valerie Quarmby, Rong Deng, Andrea Ferrante, Gemma L. Dickinson, Jan‐Stefan Van Der Walt, Lian Zhou, Xiaoying Chen, Hannah M. Jones, Jatin Narula, Sophie Tourdot, Thierry Lavé, Benjamin Ribba, Piet H. van derGraaf
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 773-776 (2019)
Externí odkaz:
https://doaj.org/article/368f598c595b469b8b9deb6681ea6d5a
Autor:
Mark R. Davies, Michael Martinec, Robert Walls, Roman Schwarz, Gary R. Mirams, Ken Wang, Guido Steiner, Andy Surinach, Carlos Flores, Thierry Lavé, Thomas Singer, Liudmila Polonchuk
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 5, Pp 100076- (2020)
Summary: There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose us
Externí odkaz:
https://doaj.org/article/8ab556035a2b4ff38523463e38599500
Publikováno v:
Metabolism: clinical and experimental. 38(6)
Prolonged parenteral nutrition frequently includes lipid emulsions. This report investigates how emulsions containing triacylglycerols of different molecular weight affect the rate of clearance in vivo and the activity in vitro of the two enzymes res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7549b92cbfa1e6ef8ed229570dee039c
https://pubmed.ncbi.nlm.nih.gov/2725290
https://pubmed.ncbi.nlm.nih.gov/2725290