Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Thierry Lave"'
Publikováno v:
New Insights into Toxicity and Drug Testing
Physiologically based pharmacokinetic (PBPK) models differ from classical PK models in that they include specific compartments for tissues involved in exposure, toxicity, biotransforma‐ tion and clearance processes connected by blood flow (Figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3415b6c7e255ea1504291b9f6226d133
http://www.intechopen.com/articles/show/title/physiologically-based-pharmacokinetic-modeling-a-tool-for-understanding-admet-properties-and-extrapo
http://www.intechopen.com/articles/show/title/physiologically-based-pharmacokinetic-modeling-a-tool-for-understanding-admet-properties-and-extrapo
Publikováno v:
Clinical Drug Investigation. 9:150-155
The objective of this study was to investigate the presence of stereoselective processes in the pharmacokinetics and metabolism of tertatolol in humans, using urinary excretion data. Six healthy male volunteers were given single 5mg oral doses of (+,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a582861192a6458469573fc5caa9b20
https://doi.org/10.2165/00044011-199509030-00003
https://doi.org/10.2165/00044011-199509030-00003
Autor:
Patrick F. Smith, Micaela B. Reddy, Sophie Le Pogam, Peter N. Morcos, Thierry Lave, Ying Ou, Karl Frank
Publikováno v:
Antimicrobial agents and chemotherapy. 56(6)
This analysis was conducted to determine whether the hepatitis C virus (HCV) viral kinetics (VK) model can predict viral load (VL) decreases for nonnucleoside polymerase inhibitors (NNPolIs) and protease inhibitors (PIs) after 3-day monotherapy studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15d862f28cebfb9adabfbc00a6a2991
https://pubmed.ncbi.nlm.nih.gov/22470110
https://pubmed.ncbi.nlm.nih.gov/22470110
Publikováno v:
Metabolism: clinical and experimental. 38(6)
Prolonged parenteral nutrition frequently includes lipid emulsions. This report investigates how emulsions containing triacylglycerols of different molecular weight affect the rate of clearance in vivo and the activity in vitro of the two enzymes res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7549b92cbfa1e6ef8ed229570dee039c
https://pubmed.ncbi.nlm.nih.gov/2725290
https://pubmed.ncbi.nlm.nih.gov/2725290
Autor:
Naga, Doha1,2 (AUTHOR), Muster, Wolfgang1 (AUTHOR), Musvasva, Eunice1 (AUTHOR), Ecker, Gerhard F.2 (AUTHOR) gerhard.f.ecker@univie.ac.at
Publikováno v:
Journal of Cheminformatics. 5/7/2022, Vol. 14 Issue 1, p1-19. 19p.
Autor:
Caruso, Antonello1 (AUTHOR) antonello.caruso@roche.com, Vollmer, Jannik2 (AUTHOR), Machacek, Matthias2 (AUTHOR), Kortvely, Elod3 (AUTHOR)
Publikováno v:
PLoS Computational Biology. 10/2/2020, Vol. 16 Issue 10, p1-23. 23p. 1 Diagram, 2 Charts, 5 Graphs.
In silico prediction of ADME and pharmacokinetics: Report of an expert meeting organised by COST B15
Publikováno v:
In European Journal of Pharmaceutical Sciences 2002 17(4):183-193
Autor:
Parrott, Neil1 neil_john.parrot@roche.com, Jones, Hannah1, Paquereau, Nicolas1, Lavé, Thierry1
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. Mar2005, Vol. 96 Issue 3, p193-199. 7p.
Publikováno v:
Journal of Pharmacokinetics & Pharmacodynamics; Dec2017, Vol. 44 Issue 6, p617-630, 14p
Publikováno v:
Journal of Pharmaceutical Investigation (2093-5552); Mar2017, Vol. 47 Issue 2, p151-161, 11p