Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Thierry Kortulewski"'
Autor:
Amandine Bery, Olivier Etienne, Laura Mouton, Sofiane Mokrani, Christine Granotier-Beckers, Laurent R. Gauthier, Justyne Feat-Vetel, Thierry Kortulewski, Elodie A. Pérès, Chantal Desmaze, Philippe Lestaveal, Vilma Barroca, Antony Laugeray, Fawzi Boumezbeur, Vincent Abramovski, Stéphane Mortaud, Arnaud Menuet, Denis Le Bihan, Jean-Pierre de Villartay, François D. Boussin
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112342- (2023)
Summary: XLF/Cernunnos is a component of the ligation complex used in classical non-homologous end-joining (cNHEJ), a major DNA double-strand break (DSB) repair pathway. We report neurodevelopmental delays and significant behavioral alterations assoc
Externí odkaz:
https://doaj.org/article/932eb1262b3c484399e5f2d802035f1e
Autor:
Marc-André Mouthon, Lise Morizur, Léa Dutour, Donovan Pineau, Thierry Kortulewski, François D. Boussin
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101784- (2020)
Summary: The production of neurons from neural stem cells (NSCs) persists throughout life in the mouse ventricular-subventricular zone (V-SVZ). We have previously reported that NSCs from adult V-SVZ are contained in cell populations expressing the ca
Externí odkaz:
https://doaj.org/article/9e6b35aed5df4132b10eabc8c39e3dff
Autor:
Biliana Todorova, Lucille Adam, Slobodan Culina, Raphaël Boisgard, Frédéric Martinon, Antonio Cosma, Mart Ustav, Thierry Kortulewski, Roger Le Grand, Catherine Chapon
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract In vivo electroporation (EP) is used to enhance the uptake of nucleic acids and its association with DNA vaccination greatly stimulates immune responses to vaccine antigens delivered through the skin. However, the effect of EP on cutaneous c
Externí odkaz:
https://doaj.org/article/d6ef145983f04a4f905a9c10ea861c5e
Autor:
Cyril Catelain, Fabio Michelet, Aurore Hattabi, Sonia Poirault-Chassac, Thierry Kortulewski, Diana Tronik-Le Roux, William Vainchenker, Evelyne Lauret
Publikováno v:
Stem Cell Research, Vol 13, Iss 3, Pp 431-441 (2014)
Understanding the role of Notch and its ligands within the different bone marrow niches could shed light on the mechanisms regulating haematopoietic progenitor cells (HPCs) maintenance and self-renewal. Here, we report that murine bone marrow HPCs ac
Externí odkaz:
https://doaj.org/article/e311910aa12e4a058dc38a5cf8cd0803
Autor:
Samir Dekali, Christelle Gamez, Thierry Kortulewski, Kelly Blazy, Patrice Rat, Ghislaine Lacroix
Publikováno v:
Toxicology Reports, Vol 1, Iss C, Pp 157-171 (2014)
As the lung is one of the main routes of exposure to manufactured nanoparticles, we developed an in vitro model resembling the alveolo-capillary barrier for the study of nanoparticle translocation. In order to provide a relevant and ethical in vitro
Externí odkaz:
https://doaj.org/article/2f2f9bee8e124836aa8858ea34fcf9ce
Autor:
Vincent Paget, Samir Dekali, Thierry Kortulewski, Romain Grall, Christelle Gamez, Kelly Blazy, Olivier Aguerre-Chariol, Sylvie Chevillard, Anne Braun, Patrice Rat, Ghislaine Lacroix
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123297 (2015)
Nanoparticle surface chemistry is known to play a crucial role in interactions with cells and their related cytotoxic effects. As inhalation is a major route of exposure to nanoparticles, we studied specific uptake and damages of well-characterized f
Externí odkaz:
https://doaj.org/article/72a4f42bd5454e2c9cf58f16d80ce4c7
Publikováno v:
PLoS Genetics, Vol 4, Iss 8, p e1000146 (2008)
The generation of a RecA filament on single-stranded DNA is a critical step in homologous recombination. Two main pathways leading to the formation of the nucleofilament have been identified in bacteria, based on the protein complexes mediating RecA
Externí odkaz:
https://doaj.org/article/132a908fca36413b97edc172c6a59d0c
Autor:
Isaline Bontemps, Celine Lallemand, Denis Biard, Nathalie Dechamps, Thierry Kortulewski, Emmanuelle Bourneuf, Capucine Siberchicot, François Boussin, Sylvie Chevillard, Anna Campalans, Jerome Lebeau
Publikováno v:
Oncology reports. 49(1)
SUMMARYThere is compelling evidence that cancer stem cells (CSCs) play an essential role in failure of conventional antitumor therapy. In breast cancer, CD24-/low/CD44+ phenotype as well as a high aldehyde dehydrogenase activity (ALDH+) are widely as
Autor:
Anne-Sophie Gille, Sébastien Jacques, Isabelle Allemand, Vilma Barroca, Lydia Riou, Thierry Kortulewski, Filippo Rosselli, F. Dumont, Franck Letourneur, Virginie Firlej, Amandine Jarysta, Pierre Fouchet, Clémentine Lapoujade
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2021, ⟨10.1093/hmg/ddab222⟩
Human Molecular Genetics, Oxford University Press (OUP), 2021, ⟨10.1093/hmg/ddab222⟩
Fanconi anemia (FA) is a rare human genetic disorder characterized by bone marrow failure, predisposition to cancer and developmental defects including hypogonadism. Reproductive defects leading to germ cell aplasia are the most consistent phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7bcbcfbd98e2d772f297881c0fe77a
https://hal-cnrs.archives-ouvertes.fr/hal-03376710/file/ddab222-1.pdf
https://hal-cnrs.archives-ouvertes.fr/hal-03376710/file/ddab222-1.pdf
Autor:
Thierry Kortulewski, Aurélia Barascu, Pascale Bertrand, Emilie Rass, Angela Moussa, Sophie Zinn-Justin, Caroline Chabance-Okumura, Paul Wanschoor, Simon Willaume, Laure Etourneaud, Ralph Scully, Xavier Veaute, Diane Genet, Anna Campalans, Jordane Depagne, Eléa Dizet, Benoit Thézé, Didier Busso, Gaëlle Pennarun, Lamya Irbah, Julien Picotto, Catherine Le Chalony
Publikováno v:
Science Advances
Lamin B1 controls 53BP1 recruitment to DNA damage.
Double-strand breaks (DSBs) are harmful lesions and a major cause of genome instability. Studies have suggested a link between the nuclear envelope and the DNA damage response. Here, we show tha
Double-strand breaks (DSBs) are harmful lesions and a major cause of genome instability. Studies have suggested a link between the nuclear envelope and the DNA damage response. Here, we show tha