Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Thierry Groblewski"'
Publikováno v:
European Journal of Pharmacology. 669:24-31
Comparison of human, rat and mouse cannabinoid CB(2) receptor primary sequences has shown significant divergence at the mRNA and protein sequence level, raising the possibility of species specific pharmacological properties. Additionally, given the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91b1a305da79433eb18d9fabcc6f599
https://doi.org/10.1016/j.ejphar.2011.08.002
https://doi.org/10.1016/j.ejphar.2011.08.002
Autor:
Amynah Amir Ali Pradhan, Christian Ndong, Cyrla Hoffert, Jennifer M. A. Laird, Dajan O'Donnell, Jean Pierre Morello, Thierry Groblewski, Carole Puma
Publikováno v:
Pain. 143:130-137
Sensory neuron-specific receptors (SNSRs) belong to a large family of GPCRs, known as Mrgs (Mas-related genes), many of which are preferentially expressed in primary afferent nociceptors. Selective SNSR agonists produce pain-like behaviors in rats, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b4b687a2d3cbe72e8a5446b28311a0
https://doi.org/10.1016/j.pain.2009.02.010
https://doi.org/10.1016/j.pain.2009.02.010
Autor:
Sophie Dautrey, Julie Ducharme, Huy Khan Vu, Denis Projean, Jean-Louis Brazier, Thierry Groblewski
Publikováno v:
Pharmaceutical Research. 22:62-70
This study was designed to examine the effect of Freund's complete adjuvant (FCA)-induced inflammation on liver P450 expression and activities in the first 7 days that followed a single FCA injection in the rat hindpaw.Rats were humanely sacrificed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5649b075c074e3cd874bb58e350847
https://doi.org/10.1007/s11095-004-9010-6
https://doi.org/10.1007/s11095-004-9010-6
Publikováno v:
European Journal of Neuroscience. 17:2750-2754
Cannabinoids have been considered for some time as potent therapeutic agents in chronic pain management. Central and systemic administration of natural, synthetic and endogenous cannabinoids produce antinociceptive and antihyperalgesic effects in bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b19df6e7d67f9b8aa54007e08b2b9a02
https://doi.org/10.1046/j.1460-9568.2003.02704.x
https://doi.org/10.1046/j.1460-9568.2003.02704.x
Autor:
Pourashraf Mehrnaz, Russell C. Mauger, Steve Wesolowski, Phillip D Edwards, Simon Sydserff, Carine Lévesque, Maxime Tremblay, Thierry Groblewski, Vijayaratnam Santhakumar, Lois Ann Lazor, Bernstein Peter Robert, James Folmer, Pascall Giguère, William Potts, Denis Labrecque, Scott Throner, Joseph Cacciola, Mark Sylvester, Mohammed Dasser, Clay W Scott, Dean G. Brown, Andrew Griffin
Publikováno v:
Journal of medicinal chemistry. 57(3)
A new series of potent and selective histamine-3 receptor (H3R) antagonists was identified on the basis of an azaspiro[2.5]octane carboxamide scaffold. Many scaffold modifications were largely tolerated, resulting in nanomolar-potent compounds in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69954ef50a32d3a1cdac6f8403f68ac6
https://pubmed.ncbi.nlm.nih.gov/24410637
https://pubmed.ncbi.nlm.nih.gov/24410637
Autor:
Didier Pruneau, Christian Siatka, Philippe Vassault, Jacky Marie, Jean-Luc Paquet, Jean-Claude Bonnafous, Renée Larguier, Eric Richard, Cecilia Ponce, Thierry Groblewski, Bernard Maigret
Publikováno v:
Journal of Biological Chemistry. 276:41100-41111
A prototypic study of the molecular mechanisms of activation or inactivation of peptide hormone G protein-coupled receptors was carried out on the human B2 bradykinin receptor. A detailed pharmacological analysis of receptor mutants possessing either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::866253f0e4f0cc41e2cb0c35f5e1f428
https://doi.org/10.1074/jbc.m104875200
https://doi.org/10.1074/jbc.m104875200
Autor:
Carole Puma, Thierry Groblewski, Françoise Mennicken, Luc Meury, Chang Qing Cao, Paul A. Cassar, Jennifer M. A. Laird, Rosemarie Panetta
Publikováno v:
Physiological genomics. 45(2)
Neuromedin U (NMU) plays an important role in a number of physiological processes, but the relative contribution of its two known receptors, NMUR1 and NMUR2, is still poorly understood. Here we report the existence of a SNP T1022→A (Val341→Glu) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a77465d8629f13fafbaeda2d3b62ea
https://pubmed.ncbi.nlm.nih.gov/23212943
https://pubmed.ncbi.nlm.nih.gov/23212943
Publikováno v:
European Journal of Biochemistry. 231:204-213
Interactions between the lamb uterine estrogen receptor occupied by estradiol, 4-hydroxytamoxifen (a non-steroidal partial estrogen antagonist) or ICI 164,384 (a steroidal pure estrogen antagonist), and the vitellogenin A2 estrogen-response element (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021b395be61b0e9a4c24697edad835fc
https://doi.org/10.1111/j.1432-1033.1995.0204f.x
https://doi.org/10.1111/j.1432-1033.1995.0204f.x
Autor:
William Brown, Tomaszewski Miroslaw, Etienne Lessard, Christopher Walpole, Wei Zhongyong, Hua Yang, Beha Sara, Sanjay Srivastava, Maxime Tremblay, Shi Yi Yue, Shawn Johnstone, Stephane St-Onge, Thierry Groblewski, Anne-Julie Archambault, Ziping Liu, Page Daniel
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(12)
Cannabinoid CB1 receptor agonists exhibit potent analgesic effects in rodents and humans, but their clinical utility as analgesic drugs is often limited by centrally mediated side effects. We report herein the preparation of N-methyl-3-(tetrahydro-2H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8398b5e47f84620dc49296ccdf8d606e
https://pubmed.ncbi.nlm.nih.gov/22607668
https://pubmed.ncbi.nlm.nih.gov/22607668
Autor:
Ji, Zhang, Cyrla, Hoffert, Huy Khang, Vu, Thierry, Groblewski, Sultan, Ahmad, Dajan, O'Donnell
Publikováno v:
The European journal of neuroscience. 17(12)
Cannabinoids have been considered for some time as potent therapeutic agents in chronic pain management. Central and systemic administration of natural, synthetic and endogenous cannabinoids produce antinociceptive and antihyperalgesic effects in bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20fa68ccdeee86b761c77ef8e083abe3
https://pubmed.ncbi.nlm.nih.gov/12823482
https://pubmed.ncbi.nlm.nih.gov/12823482