Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational study

Autor: Kim Philipp Jablonski, Leopold Carron, Julien Mozziconacci, Thierry Forné, Marc-Thorsten Hütt, Annick Lesne

Publikováno v: Human Genomics, Vol 16, Iss 1, Pp 1-15 (2022)

Abstract Background Genome-wide association studies have identified statistical associations between various diseases, including cancers, and a large number of single-nucleotide polymorphisms (SNPs). However, they provide no direct explanation of the

Externí odkaz: https://doaj.org/article/971c30040d5841b98ac163c4f768dd70

H19 antisense RNA can up-regulate Igf2 transcription by activation of a novel promoter in mouse myoblasts.

Autor: Van Giang Tran, Franck Court, Anne Duputié, Etienne Antoine, Nathalie Aptel, Laura Milligan, Françoise Carbonell, Marie-Noëlle Lelay-Taha, Jacques Piette, Michaël Weber, Didier Montarras, Christian Pinset, Luisa Dandolo, Thierry Forné, Guy Cathala

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37923 (2012)

It was recently shown that a long non-coding RNA (lncRNA), that we named the 91H RNA (i.e. antisense H19 transcript), is overexpressed in human breast tumours and contributes in trans to the expression of the Insulin-like Growth Factor 2 (IGF2) gene

Externí odkaz: https://doaj.org/article/ee39985557a84364b441e1ede4cdd599

Quantitative Chromosome Conformation Capture (3C-qPCR)

Autor: Cosette, Rebouissou, Séphora, Sallis, Thierry, Forné

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2532

Many population-based methods investigating chromatin dynamics and organization in eukaryotes are based on the chromosome conformation capture (3C) method. Here, we provide an updated version of the quantitative 3C (3C-qPCR) protocol for improved and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc6bcd55f111e6f998b584b33179aef6
https://pubmed.ncbi.nlm.nih.gov/35867242

Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster

Autor: Jean-François Théroux, Jennie Yang, Kathryn Vaillancourt, Deborah C. Mash, Alberto J. López, Gustavo Turecki, Corina Nagy, Erin S. Calipari, Naguib Mechawar, Carl Ernst, Volodymyr Yerko, Benoit Labonté, Thierry Forné, Kimberly C. Thibeault, Gary G. Chen, Eric J. Nestler, Zahia Aouabed

Publikováno v: Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2021, 26, pp.3134-3151. ⟨10.1038/s41380-020-00909-x⟩
Molecular psychiatry

Epigenetic mechanisms, like those involving DNA methylation, are thought to mediate the relationship between chronic cocaine dependence and molecular changes in addiction-related neurocircuitry, but have been understudied in human brain. We initially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301da56c49f3dbafe88fcbb50acadd0c
https://doi.org/10.1038/s41380-020-00909-x

Quantitative Chromosome Conformation Capture (3C-qPCR)

Autor: Cosette Rebouissou, Séphora Sallis, Thierry Forné

Publikováno v: Spatial Genome Organization ISBN: 9781071624968
Spatial Genome Organization: Methods and Protocols
Spatial Genome Organization: Methods and Protocols, In press

International audience; Many population-based methods investigating chromatin dynamics and organization in eukaryotes are based on the Chromosome Conformation Capture (3C) method. Here, we provide an updated version of the quantitative 3C (3C-qPCR) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27e53faf2a058207578aba28700b2b2
https://doi.org/10.1007/978-1-0716-2497-5_1