Peptidoglycan potentiates the membrane disrupting effect of the carboxyamidated form of DMS-DA6, a Gram-positive selective antimicrobial peptide isolated from Pachymedusa dacnicolor skin.

Autor: Sébastien Cardon, Emmanuelle Sachon, Ludovic Carlier, Thierry Drujon, Astrid Walrant, Estefanía Alemán-Navarro, Verónica Martínez-Osorio, Dominique Guianvarc'h, Sandrine Sagan, Yannick Fleury, Rodrigue Marquant, Christophe Piesse, Yvonne Rosenstein, Constance Auvynet, Claire Lacombe

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0205727 (2018)

The occurrence of nosocomial infections has been on the rise for the past twenty years. Notably, infections caused by the Gram-positive bacteria Staphylococcus aureus represent a major clinical problem, as an increase in antibiotic multi-resistant st

Externí odkaz: https://doaj.org/article/78b544e90a0947459e588490d3adcb67

A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases

Autor: Gérard Bolbach, Robert H. Dodd, Emmanuelle Sachon, Olivier Pamlard, Sandra Beaupierre, Dominique Guianvarc'h, Thierry Drujon, Sandrine Sagan, Fabienne Burlina, Catherine Guillou, Karine Guitot

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, 2017, 409 (15), pp.3767-3777. ⟨10.1007/s00216-017-0319-5⟩

International audience; Histone lysine methylation is associated with essential biological functions like transcription activation or repression, depending on the position and the degree of methylation. This post-translational modification is introdu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb293a7043393dcca9550772d355e5bc
https://pubmed.ncbi.nlm.nih.gov/28389916

Inhibition of Diamino Pelargonic Acid Aminotransferase, an Enzyme of the Biotin Biosynthetic Pathway, by Amiclenomycin: A Mechanistic Study

Autor: Olivier Ploux, Denis Lesage, Stéphane Mann, Dominique Florentin, Andrée Marquet, Thierry Drujon

Publikováno v: Helvetica Chimica Acta. 86:3836-3850

The mechanism of action of amiclenomycin (1a), a naturally occuring inhibitor of diaminopelargonic acid aminotransferase, has been established. The enzyme catalyzes the formation of an aromatic adduct between the inhibitor and pyridoxal-5′-phosphat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d149da7810e5dc327c53fd76ac7880f4
https://doi.org/10.1002/hlca.200390322

Synthesis and Evaluation of Analogues of N-Phthaloyl-L-tryptophan (RG108) as Inhibitors of DNA Methyltransferase 1

Autor: Alexandre Ceccaldi, Philippe Schambel, Catherine Senamaud-Beaufort, Thierry Drujon, Christine Champion, Philippe Karoyan, Paola B. Arimondo, Gaël Marloie, Dominique Guianvarc'h, Saâdia Asgatay, Arumugam Rajavelu, Alexandre Erdmann, Olivier Lequin, Albert Jeltsch

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2013, 57 (2), pp.421-434. ⟨10.1021/jm401419p⟩
Journal of Medicinal Chemistry, 2013, 57 (2), pp.421-434. ⟨10.1021/jm401419p⟩

International audience; : DNA methyltransferases (DNMT) are promising drug targets in cancer provided that new, more specific, and chemically stable inhibitors are discovered. Among the non-nucleoside DNMT inhibitors, N-Phthaloyl-L-tryptophan 1 (RG10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0452e3b2b46d795a16ee9931438d23
https://hal.archives-ouvertes.fr/hal-00920710

An active site mutant of Escherichia coli cyclopropane fatty acid synthase forms new non-natural fatty acids providing insights on the mechanism of the enzymatic reaction

Autor: Dominique Guianvarc'h, Isabelle Correia, Olivier Ploux, Thierry Drujon, Guangqi E

Publikováno v: Biochimie
Biochimie, Elsevier, 2013, 95 (12), pp.2336-2344. ⟨10.1016/j.biochi.2013.08.007⟩
Psychological Science
Psychological Science, 2013, 95 (12), pp.2336-2344. ⟨10.1016/j.biochi.2013.08.007⟩
Biochimie, 2013, 95 (12), pp.2336-2344. ⟨10.1016/j.biochi.2013.08.007⟩
Psychological Science, Association for Psychological Science, 2013, 95 (12), pp.2336-2344. ⟨10.1016/j.biochi.2013.08.007⟩

International audience; : We have produced and purified an active site mutant of the Escherichia coli cyclopropane fatty acid synthase (CFAS) by replacing the strictly conserved G236 within cyclopropane synthases, by a glutamate residue, which corres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8be0384a5a16c7679c371573b330787
https://pubmed.ncbi.nlm.nih.gov/23954860