Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thierry Clerc"'
Autor:
Alain Beck, Charlotte Beau-Larvor, Alain Batton, Laurence Zanna, Frédéric Marion, Sarah Cianférani, Philippe Maillos, Jean-François Haeuw, Marion Millet, Thierry Clerc, Barbara Akla, Martine Farrie, Marie-Claire Janin, Nathalie Corvaia, Cyrille Dreyfus, Celine Thuilliez
Publikováno v:
Cancer Research. 80:4054-4054
There are currently 5 antibody drug conjugates (ADC) on the market and over 80 other ADCs evaluated in the clinic. The major drawbacks of the commonly employed bioconjugation methods based on nucleophilic coupling to lysine and cysteine are the non-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84227d4c67908831d0a23c267340584c
https://doi.org/10.1158/1538-7445.am2020-4054
https://doi.org/10.1158/1538-7445.am2020-4054
Autor:
Isabelle Limon, Gilbert Bereziat, Claire Kanony-Truc, Véronique Mateo, Mégane Babiak, Nicolas Amalric, Justine Hur, Thierry Clerc, Régis Blaise
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(9)
Cerebral amyloid angiopathy (CAA) is a major contributor to Alzheimer's disease (AD) pathogenesis. Like AD, CAA is often accompanied by marked inflammation, aggravating associated vasculopathies. No evidence-based prevention or treatment strategies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d5872c1ca59e827ec2f77e65d5496e
https://pubmed.ncbi.nlm.nih.gov/29620941
https://pubmed.ncbi.nlm.nih.gov/29620941
Autor:
Thierry Clerc
Publikováno v:
International Journal of Complementary & Alternative Medicine. 1
Chronic conditions such as diabetes or cardiovascular diseases bring suffering to many people in the rich and developing world alike. The fact that they are becoming more frequent is also a significant financial burden for the patients and society al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b21eeb91d56c3009faf3a1d2ecde80
https://doi.org/10.15406/ijcam.2015.01.00040
https://doi.org/10.15406/ijcam.2015.01.00040
Autor:
Nicolas Monjotin, Thomas Similowski, Eric Garrigue, Guillaume D’Auzers, Thierry Clerc, Philippe Devillier
Publikováno v:
Respiratory Research
Respiratory Research, BioMed Central, 2015, 16 (1), pp.68. ⟨10.1186/s12931-015-0227-1⟩
Respiratory Research, 2015, 16 (1), pp.68. ⟨10.1186/s12931-015-0227-1⟩
Respiratory Research, BioMed Central, 2015, 16 (1), pp.68. ⟨10.1186/s12931-015-0227-1⟩
Respiratory Research, 2015, 16 (1), pp.68. ⟨10.1186/s12931-015-0227-1⟩
Background Long acting bronchodilators are the standard of care in the management of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the efficacy and safety of V0162, a novel anticholinergic agent with bronchodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8bfe326f06101bdae7a84a41930b5a
https://hal.sorbonne-universite.fr/hal-01162400/document
https://hal.sorbonne-universite.fr/hal-01162400/document
Autor:
Emmanuel Naline, Peter Heusler, Thierry Clerc, Didier Cussac, Stéphanie Tardif, Philippe Devillier
Publikováno v:
Pharmacological research. 100
The anticholinergic properties of the mequitazine enantiomer V0162 make it a drug candidate for the treatment of chronic obstructive airway diseases. Here, we compared V0162’s in vitro pharmacological activity at recombinant human M 3 muscarinic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c8f9911abf9163ba67d5b34ac77312
https://pubmed.ncbi.nlm.nih.gov/26241178
https://pubmed.ncbi.nlm.nih.gov/26241178
Publikováno v:
Journal de Radiologie. 87:919-926
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb53ba8f5ded6f6cf1a10d869f63c45
https://doi.org/10.1016/s0221-0363(06)74108-7
https://doi.org/10.1016/s0221-0363(06)74108-7
Autor:
Olivier Ghez, Benoit D’journo, Thierry Clerc, Pascal Thomas, Fabrice Barlesi, Christophe Doddoli, Stéphane Robitail
Publikováno v:
International Journal of Pharmaceutics. 297:180-189
MTX-liposomes, prepared with a polymerised core (LSP), were administered in anaesthetised rats by pulmonary instillation versus free drug. No toxicological effects were macroscopically observed. After each time point: 15, 30, 60 and 90 min, animals w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c749dd3ee5b36e9ec8c54ee9db024f0
https://doi.org/10.1016/j.ijpharm.2005.03.012
https://doi.org/10.1016/j.ijpharm.2005.03.012
Autor:
Myriam Witvrouw, Jean-Louis Kraus, Patrick Vlieghe, Jean-Pierre Salles, Erik De Clercq, Thierry Clerc, Christophe Pannecouque
Publikováno v:
Journal of Medicinal Chemistry. 44:3014-3021
New 5'-O-carbonate prodrugs of zidovudine (AZT) have been synthesized in order to enhance its uptake by HIV-1 infected cells, to improve its anti-HIV potency, and to optimize the intramolecular cyclic rearrangement process related to the 5'-O-(4-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78376d3fe14337247b4cd19eebd8964e
https://doi.org/10.1021/jm010863i
https://doi.org/10.1021/jm010863i
Autor:
Henry Portugal, Huguette Lafont, Olivier Morel, Magali Chautan, A M Pauli, Michel Jomier, Thierry Clerc, Françoise Chanussot, Claude Laruelle, Michèle Senft
Publikováno v:
European Journal of Pharmacology. 235:59-68
Crilvastatin is a drug from the pyrrolidone family that had been shown to induce non-competitive inhibition of rat hydroxymethylglutaryl-coenzyme A reductase activity in vitro. The aim of this study was to evaluate the activity of crilvastatin on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c22752624d42eb3d7fba40f0f2e4186
https://doi.org/10.1016/0014-2999(93)90820-8
https://doi.org/10.1016/0014-2999(93)90820-8
Autor:
Erik De Clercq, Patrick Vlieghe, Jean-Claude Chermann, Thierry Clerc, Frédéric Bihel, Myriam Witvrouw, Jean-Pierre Salles, Christophe Pannecouque, Jean-Louis Kraus
Publikováno v:
ChemInform. 32
Prodrugs of zidovudine (AZT) have been synthesized in an effort to enhance its uptake by HIV-1 infected cells and its anti-HIV activity. The 5‘-OH function of AZT was functionalized with various enzymatically labile alkyl groups using specific proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::061c90f5417af6d2b51be9b0650c4af6
https://doi.org/10.1002/chin.200124210
https://doi.org/10.1002/chin.200124210