Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Thierry Christophe"'
Autor:
Angélica Cristina Rhoden, João Garibaldi Almeida Viana, Vicente Celestino Pires Silveira, Thierry Christophe Bonaudo, Gilberto Vilmar Kozloski
Publikováno v:
Agriculture, Vol 13, Iss 8, p 1524 (2023)
In recent decades, significant changes have driven the advancement of agricultural production systems in Brazil. The objective of this study is to analyze the efficiency and transformation of the agricultural production system in the Ibirapuitã Envi
Externí odkaz:
https://doaj.org/article/64fd309c2d064a55989b51ee29dcc735
Autor:
Gert de Wilde, Maarten Gees, Sara Musch, Katleen Verdonck, Mia Jans, Anne-Sophie Wesse, Ashvani K. Singh, Tzyh-Chang Hwang, Thierry Christophe, Mathieu Pizzonero, Steven Van der Plas, Nicolas Desroy, Marlon Cowart, Pieter Stouten, Luc Nelles, Katja Conrath
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The deletion of phenylalanine at position 508 (F508del) in cystic fibrosis transmembrane conductance regulator (CFTR) causes a severe defect in folding and trafficking of the chloride channel resulting in its absence at the plasma membrane of epithel
Externí odkaz:
https://doaj.org/article/8d68380c55104f5f99c3962f9d0c136b
Autor:
Tae-Hee Kim, Yoonae Ko, Thierry Christophe, Jonathan Cechetto, Junwon Kim, Kyoung-Ae Kim, Annette S Boese, Jean-Michel Garcia, Denis Fenistein, Moon Kyeong Ju, Junghwan Kim, Sung-Jun Han, Ho Jeong Kwon, Vincent Brondani, Peter Sommer
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68767 (2013)
Classical target-based, high-throughput screening has been useful for the identification of inhibitors for known molecular mechanisms involved in the HIV life cycle. In this study, the development of a cell-based assay that uses a phenotypic drug dis
Externí odkaz:
https://doaj.org/article/aa8935f6c8a64286a69f9c66334d0492
Autor:
Priscille Brodin, Yannick Poquet, Florence Levillain, Isabelle Peguillet, Gerald Larrouy-Maumus, Martine Gilleron, Fanny Ewann, Thierry Christophe, Denis Fenistein, Jichan Jang, Mi-Seon Jang, Sei-Jin Park, Jean Rauzier, Jean-Philippe Carralot, Rachel Shrimpton, Auguste Genovesio, Jesus A Gonzalo-Asensio, Germain Puzo, Carlos Martin, Roland Brosch, Graham R Stewart, Brigitte Gicquel, Olivier Neyrolles
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001100 (2010)
The ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we developed a high throughput phenotypi
Externí odkaz:
https://doaj.org/article/3fbdc7f8e69e49e48b8fb602f57de815
Autor:
Jair L Siqueira-Neto, Ok-Ryul Song, Hyunrim Oh, Jeong-Hun Sohn, Gyongseon Yang, Jiyoun Nam, Jiyeon Jang, Jonathan Cechetto, Chang Bok Lee, Seunghyun Moon, Auguste Genovesio, Eric Chatelain, Thierry Christophe, Lucio H Freitas-Junior
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 5, p e675 (2010)
Drugs currently available for leishmaniasis treatment often show parasite resistance, highly toxic side effects and prohibitive costs commonly incompatible with patients from the tropical endemic countries. In this sense, there is an urgent need for
Externí odkaz:
https://doaj.org/article/ccd4fdb790414498a3983eca222dd7eb
Autor:
Thierry Christophe, Mary Jackson, Hee Kyoung Jeon, Denis Fenistein, Monica Contreras-Dominguez, Jaeseung Kim, Auguste Genovesio, Jean-Philippe Carralot, Fanny Ewann, Eun Hye Kim, Sae Yeon Lee, Sunhee Kang, Min Jung Seo, Eun Jung Park, Henrieta Skovierová, Ha Pham, Giovanna Riccardi, Ji Youn Nam, Laurent Marsollier, Marie Kempf, Marie-Laure Joly-Guillou, Taegwon Oh, Won Kyung Shin, Zaesung No, Ulf Nehrbass, Roland Brosch, Stewart T Cole, Priscille Brodin
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000645 (2009)
A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tub
Externí odkaz:
https://doaj.org/article/99417d33f11047f2814f85afb272f7e0
Akademický článek
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Autor:
Stéphanie Lavazais, Manja Jargosch, Sonia Dupont, Frédéric Labéguère, Christel Menet, Catherine Jagerschmidt, Frenz Ohm, Laszlo Kupcsik, Isabelle Parent, Céline Cottereaux, Florence Marsais, Line Oste, An Van de Water, Thierry Christophe, Steve De Vos, Padraic Fallon, Felix Lauffer, Philippe Clément-Lacroix, Kilian Eyerich, Reginald Brys
Publikováno v:
Science Translational Medicine. 15
Innate immunity not only shapes the way epithelial barriers interpret environmental cues but also drives adaptive responses. Therefore, modulators of innate immune responses are expected to have high therapeutic potential across immune-mediated infla
Autor:
L. Lepescheux, R. Gosmini, F. De Ceuninck, Thierry Christophe, E. van der Aar, I. Botez, Nele Vandervoort, Pierre Deprez, D. Amantini, Roland Blanque, D. Merciris, Robert Touitou, Philippe Clément-Lacroix, C. Cottereaux, S. Meurisse, Patrick Mollat, F. Brebion, D. Comas, Christopher B. Little, Margaret M. Smith
Publikováno v:
Osteoarthritis and Cartilage. 30:291-301
Summary Objective A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a key enzyme in degradation of cartilage in osteoarthritis (OA). We report the pharmacological characterization of GLPG1972/S201086, a new, potent and sel
Autor:
Alain Monjardet, Thierry Christophe, Nicolas Triballeau, Helene Jary, Luke Jonathan Alvey, Romain Luc Marie Gosmini, Frédéric André De Ceuninck, Pierre Deprez, Robert Touitou, Roland Blanque, D. Amantini, Nele Vandervoort, Ellen van der Aar, Philip Leonard, F. Brebion, Patrick Mollat, Natacha Bienvenu, C. Cottereaux, I. Botez, Varin Marie Laurence Claire, Christophe Peixoto
Publikováno v:
Journal of Medicinal Chemistry. 64:2937-2952
There are currently no approved disease-modifying osteoarthritis (OA) drugs (DMOADs). The aggrecanase ADAMTS-5 is key in the degradation of human aggrecan (AGC), a component of cartilage. Therefore, ADAMTS-5 is a promising target for the identificati