Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Thierry Bruyère"'
Autor:
Thierry Bruyère, Georges Gaillard
Publikováno v:
Connexions. :141-154
La dialogique inclusion/exclusion est l’une des dynamiques-clefs qui « travaille » nos societes hypermodernes. Les « exclus » sont les temoins vivants de l’insupportable de la destructuration de la Polis (du « vivre ensemble » dans la cite)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4949497ce1c48fa780ac3e7053a967
https://doi.org/10.3917/cnx.110.0141
https://doi.org/10.3917/cnx.110.0141
Autor:
Markus Gude, Georg Rueedi, Thomas Pfeifer, Christian Hubschwerlen, Daniel Ritz, Thierry Kimmerlin, L. Jacob, A.-C. Blumstein, Daniel Bur, Alain Chambovey, Lars Prade, Peter Seiler, Philippe Panchaud, Eric A. Ertel, Thierry Bruyère
Publikováno v:
Journal of Medicinal Chemistry. 60:3755-3775
Our strategy to combat resistant bacteria consisted of targeting the GyrB/ParE ATP-binding sites located on bacterial DNA gyrase and topoisomerase IV and not utilized by marketed antibiotics. Screening around the minimal ethyl urea binding motif led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd48a433f27169780b7c54901c1e1ae
https://doi.org/10.1021/acs.jmedchem.6b01834
https://doi.org/10.1021/acs.jmedchem.6b01834
Autor:
Thierry Bruyère, Eric A. Ertel, Stephanie Enderlin-Paput, Hans H. Locher, Michel Enderlin-Paput, Daniel Ritz, Christopher Kohl, Jean-Christophe Gauvin, Patrick Hess, Jean-Philippe Surivet, Azely Mirre, Daniel Bur, Cornelia Zumbrunn, Georg Rueedi, Christian Hubschwerlen, Peter Seiler
Publikováno v:
Journal of Medicinal Chemistry. 60:3776-3794
There is an urgent unmet medical need for novel antibiotics that are effective against a broad range of bacterial species, especially multidrug resistant ones. Tetrahydropyran-based inhibitors of bacterial type II topoisomerases (DNA gyrase and topoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03730300d43232dbf6451dab25886d78
https://doi.org/10.1021/acs.jmedchem.6b01831
https://doi.org/10.1021/acs.jmedchem.6b01831
Autor:
Philippe Pfaff, Andreja Knezevic, Susanne Schroeder, Hans H. Locher, Thierry Bruyère, Patrick Caspers, Daniel Ritz, Wolfgang Keck
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:901-908
Cadazolid is a new oxazolidinone-type antibiotic currently in clinical development for the treatment of Clostridium difficile -associated diarrhea. Here, we report investigations on the mode of action and the propensity for spontaneous resistance dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c67db593b7c5653c935ff9f362e3977
https://doi.org/10.1128/aac.01831-13
https://doi.org/10.1128/aac.01831-13
Autor:
Daniel Bur, Azely Mirre, Michel Enderlin-Paput, Georg Rueedi, Christian Hubschwerlen, Hans H. Locher, Daniel Ritz, Cornelia Zumbrunn, Wolfgang Keck, Maria Boehme, Marina Dos Santos, Jean-Christophe Gauvin, Peter Seiler, Jean-Philippe Surivet, Verena Kaegi, Jonathan Delers, Christopher Kohl, Thierry Bruyère, Mika Gaertner
Publikováno v:
Journal of Medicinal Chemistry. 56:7396-7415
There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed8ae2c35d8e3bcbd6ebfe5d79033c9
https://doi.org/10.1021/jm400963y
https://doi.org/10.1021/jm400963y
Autor:
Marina Dos Santos, Daniel Ritz, Verena Kaegi, Azely Mirre, Maria Weiss, Stéphanie Kraemer, Daniel Bur, Michel Enderlin-Paput, Jean-Christophe Gauvin, Hakim Hadana, Georg Rueedi, Thierry Bruyère, Christian Hubschwerlen, Peter Seiler, Mika Gaertner, Jonathan Delers, Christopher Kohl, Wolfgang Keck, Jean-Philippe Surivet, Hans H. Locher, Patrick Hess, Eric A. Ertel, Cornelia Zumbrunn, Romain Sube
Publikováno v:
Journal of medicinal chemistry. 58(2)
Novel antibacterial drugs that are effective against infections caused by multidrug resistant pathogens are urgently needed. In a previous report, we have shown that tetrahydropyran-based inhibitors of bacterial type II topoisomerases (DNA gyrase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e943cd2f129c2bf098a7a5867bb79e41
https://pubmed.ncbi.nlm.nih.gov/25494934
https://pubmed.ncbi.nlm.nih.gov/25494934
Autor:
César Fernández, Thierry Bruyère, Egon Mösinger, Paul Ramage, Thomas Szyperski, Kurt Wüthrich
Publikováno v:
Journal of Molecular Biology. 266:576-593
The nuclear magnetic resonance (NMR) structure of the 15 kDa pathogenesis-related protein P14a, which displays antifungicidal activity and is induced in tomato leaves as a response to pathogen infection, was determined using 15N/13C doubly labeled an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196a5d74e07a56ca9abdb97464bce338
https://doi.org/10.1006/jmbi.1996.0772
https://doi.org/10.1006/jmbi.1996.0772