Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Thierry, Soussi"'
Autor:
Adar Yaacov, Gregory Lazarian, Tatjana Pandzic, Simone Weström, Panagiotis Baliakas, Samia Imache, Valérie Lefebvre, Florence Cymbalista, Fanny Baran-Marszak, Shai Rosenberg, Thierry Soussi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Intratumoral heterogeneity is an important clinical challenge because low burden clones expressing specific genetic alterations drive therapeutic resistance mechanisms. We have developed CAVE (cancer-associated variant enrichment), a gene-ag
Externí odkaz:
https://doaj.org/article/245ecc24d1874afcb302e97755ef1cba
Autor:
Qiang Zhang, Dimitrios-Ilias Balourdas, Bruno Baron, Alon Senitzki, Tali E. Haran, Klas G. Wiman, Thierry Soussi, Andreas C. Joerger
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-11 (2022)
Abstract The extremophile Alvinella pompejana, an annelid worm living on the edge of hydrothermal vents in the Pacific Ocean, is an excellent model system for studying factors that govern protein stability. Low intrinsic stability is a crucial factor
Externí odkaz:
https://doaj.org/article/6293f38a3c7d4577850a7e1f3760078f
Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract The diagnosis of somatic and germline TP53 mutations in human tumors or in individuals prone to various types of cancer has now reached the clinic. To increase the accuracy of the prediction of TP53 variant pathogenicity, we gathered functio
Externí odkaz:
https://doaj.org/article/0b0146cc59364ff9b0de255c6286014d
Autor:
Thierry Soussi, Panagiotis Baliakas
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Locus-specific databases are invaluable tools for both basic and clinical research. The extensive information they contain is gathered from the literature and manually curated by experts. Cancer genome sequencing projects generate an immense amount o
Externí odkaz:
https://doaj.org/article/3aa641d4a5d9454885cf8a72d8cd77bb
Autor:
Sue Haupt, Franco Caramia, Alan Herschtal, Thierry Soussi, Guillermina Lozano, Hu Chen, Han Liang, Terence P. Speed, Ygal Haupt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
There is disproportionally high cancer prevalence in males. Here, the authors analyse the tumour suppressor p53 in sporadic cancers, highlighting a higher incidence of its mutation in males. Males are further disadvantaged by a failure to shield agai
Externí odkaz:
https://doaj.org/article/1a749f75f57f428ea7b81ae7e79a67f1
Autor:
Lawrence A. Donehower, Thierry Soussi, Anil Korkut, Yuexin Liu, Andre Schultz, Maria Cardenas, Xubin Li, Ozgun Babur, Teng-Kuei Hsu, Olivier Lichtarge, John N. Weinstein, Rehan Akbani, David A. Wheeler
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1370-1384.e5 (2019)
Summary: The TP53 tumor suppressor gene is frequently mutated in human cancers. An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of p53 pathway in
Externí odkaz:
https://doaj.org/article/9022b74d0598404a877ef42a55e267d2
Autor:
Jesse J. Salk, Kaitlyn Loubet-Senear, Elisabeth Maritschnegg, Charles C. Valentine, Lindsey N. Williams, Jacob E. Higgins, Reinhard Horvat, Adriaan Vanderstichele, Daniela Nachmanson, Kathryn T. Baker, Mary J. Emond, Emily Loter, Maria Tretiakova, Thierry Soussi, Lawrence A. Loeb, Robert Zeillinger, Paul Speiser, Rosa Ana Risques
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 132-144.e3 (2019)
Summary: High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant cancer molecules in minimally invasive body fluid samples. We demonstrate 80% sensitivity for ovarian c
Externí odkaz:
https://doaj.org/article/321fc6803f4e46e7a0f6986070caf555
Autor:
Valentina Sica, Jose Manuel Bravo-San Pedro, Valentina Izzo, Jonathan Pol, Sandra Pierredon, David Enot, Sylvère Durand, Noélie Bossut, Alexis Chery, Sylvie Souquere, Gerard Pierron, Evangelia Vartholomaiou, Naoufal Zamzami, Thierry Soussi, Allan Sauvat, Laura Mondragón, Oliver Kepp, Lorenzo Galluzzi, Jean-Claude Martinou, Holger Hess-Stumpp, Karl Ziegelbauer, Guido Kroemer, Maria Chiara Maiuri
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 820-834.e9 (2019)
Summary: Inhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-yl)piperazine (BAY87-2243, abbreviated as B87), a complex I inhibitor,
Externí odkaz:
https://doaj.org/article/2e77a726e5534371a4b12359e5c7bfd6
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a5041ed0c39a5c338200d6029762d5
https://doi.org/10.1158/1535-7163.22518652.v1
https://doi.org/10.1158/1535-7163.22518652.v1
Interrogating the genomics of circulating tumor DNA (ctDNA; the liquid biopsy) has advantages in patients in whom tissue biopsy is difficult. However, the reported concordance between genomic analysis of tissue DNA and ctDNA is variable among studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10aca1750bc9ac0e2077279621fc5b4d
https://doi.org/10.1158/1535-7163.c.6542047.v1
https://doi.org/10.1158/1535-7163.c.6542047.v1