Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Thierry, Coppola"'
Publikováno v:
Cells, Vol 13, Iss 5, p 420 (2024)
Neurotransmission occurs within highly specialized compartments forming the active synapse where the complex organization and dynamics of the interactions are tightly orchestrated both in time and space. Post-translational modifications (PTMs) are ce
Externí odkaz:
https://doaj.org/article/8749907bbc7f4e1897b1797e927ec4d4
Autor:
Thierry Coppola, Guillaume Daziano, Ilona Legroux, Sophie Béraud-Dufour, Nicolas Blondeau, Patricia Lebrun
Publikováno v:
Cells, Vol 12, Iss 23, p 2768 (2023)
Research in the field of pharmacology aims to generate new treatments for pathologies. Nowadays, there are an increased number of chronic disorders that severely and durably handicap many patients. Among the most widespread pathologies, obesity, whic
Externí odkaz:
https://doaj.org/article/70a557f00c384720b63c425ad556abff
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
The pharmacological properties and physiological roles of the type I receptor sortilin, also called neurotensin receptor-3, are various and complex. Sortilin is involved in important biological functions from neurotensin and pro-Nerve Growth Factor s
Externí odkaz:
https://doaj.org/article/da4614af9b0a4e759338cba3f6c9021c
Publikováno v:
Cells, Vol 2, Iss 1, Pp 124-135 (2013)
The neuropeptide, neurotensin, exerts numerous biological functions, including an efficient anti-apoptotic role, both in the central nervous system and in the periphery. This review summarizes studies that clearly evidenced the protective effect of n
Externí odkaz:
https://doaj.org/article/7f3772913e46472cb69f94a047215744
Autor:
Céline Hivelin, Sophie Béraud-Dufour, Christelle Devader, Amar Abderrahmani, Sébastien Moreno, Hamid Moha ou Maati, Alaeddine Djillani, Catherine Heurteaux, Marc Borsotto, Jean Mazella, Thierry Coppola
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the contro
Externí odkaz:
https://doaj.org/article/5ce0b490bc014551ba4a958c50acb044
Autor:
Vilailak Prachyawarakorn, Veronika Leláková, Catherine Heurteaux, Phanruethai Pailee, Nicolas Blondeau, Jean Mazella, Sophie Béraud-Dufour, Jiří Václavík, Jan Hošek, Catherine Widmann, Karel Šmejkal, Thierry Coppola
Publikováno v:
Journal of Ethnopharmacology
Journal of Ethnopharmacology, Elsevier, 2020, pp.113147. ⟨10.1016/j.jep.2020.113147⟩
Journal of Ethnopharmacology, Elsevier, 2020, pp.113147. ⟨10.1016/j.jep.2020.113147⟩
Ethnopharmacological relevance Macaranga Thou. (Euphorbiaceae) is a large genus that comprises over 300 species distributed between Western Africa and the islands of the South Pacific. Plants of this genus have a long-standing history of use in tradi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842e0299b41b150681329b02e226d1ff
https://hal.archives-ouvertes.fr/hal-02912692/document
https://hal.archives-ouvertes.fr/hal-02912692/document
Autor:
Runhild Gammelsaeter, Thierry Coppola, Païkan Marcaggi, Jon Storm-Mathisen, Farrukh A Chaudhry, David Attwell, Romano Regazzi, Vidar Gundersen
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22960 (2011)
In the brain, glutamate is an extracellular transmitter that mediates cell-to-cell communication. Prior to synaptic release it is pumped into vesicles by vesicular glutamate transporters (VGLUTs). To inactivate glutamate receptor responses after rele
Externí odkaz:
https://doaj.org/article/ce013e0324d6440cbf1388615fce098a
Autor:
Jean Mazella, Olivier Pétrault, Guillaume Lucas, Emmanuel Deval, Sophie Béraud-Dufour, Carine Gandin, Malika El-Yacoubi, Catherine Widmann, Alice Guyon, Eric Chevet, Said Taouji, Grégory Conductier, Alain Corinus, Thierry Coppola, Gabriella Gobbi, Jean-Louis Nahon, Catherine Heurteaux, Marc Borsotto
Publikováno v:
PLoS Biology, Vol 8, Iss 4, p e1000355 (2010)
Current antidepressant treatments are inadequate for many individuals, and when they are effective, they require several weeks of administration before a therapeutic effect can be observed. Improving the treatment of depression is challenging. Recent
Externí odkaz:
https://doaj.org/article/1ce8e5d7cde54153ac1956b5d289c1e1
Publikováno v:
Biochemical and Biophysical Research Communications. 482:87-92
In this work, we aimed to correlate the expression of sortilin with the production of sortilin-derived propeptide (PE) during adipocyte differentiation, insulin resistance and inflammation. We also investigated the effect of spadin, a shorter analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05dc19615c8cf4129f10ecf0949d1da4
https://doi.org/10.1016/j.bbrc.2016.10.139
https://doi.org/10.1016/j.bbrc.2016.10.139