Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Thierry, Christophe"'
Autor:
Angélica Cristina Rhoden, João Garibaldi Almeida Viana, Vicente Celestino Pires Silveira, Thierry Christophe Bonaudo, Gilberto Vilmar Kozloski
Publikováno v:
Agriculture, Vol 13, Iss 8, p 1524 (2023)
In recent decades, significant changes have driven the advancement of agricultural production systems in Brazil. The objective of this study is to analyze the efficiency and transformation of the agricultural production system in the Ibirapuitã Envi
Externí odkaz:
https://doaj.org/article/64fd309c2d064a55989b51ee29dcc735
Akademický článek
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Autor:
Gert de Wilde, Maarten Gees, Sara Musch, Katleen Verdonck, Mia Jans, Anne-Sophie Wesse, Ashvani K. Singh, Tzyh-Chang Hwang, Thierry Christophe, Mathieu Pizzonero, Steven Van der Plas, Nicolas Desroy, Marlon Cowart, Pieter Stouten, Luc Nelles, Katja Conrath
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The deletion of phenylalanine at position 508 (F508del) in cystic fibrosis transmembrane conductance regulator (CFTR) causes a severe defect in folding and trafficking of the chloride channel resulting in its absence at the plasma membrane of epithel
Externí odkaz:
https://doaj.org/article/8d68380c55104f5f99c3962f9d0c136b
Autor:
L. Lepescheux, R. Gosmini, F. De Ceuninck, Thierry Christophe, E. van der Aar, I. Botez, Nele Vandervoort, Pierre Deprez, D. Amantini, Roland Blanque, D. Merciris, Robert Touitou, Philippe Clément-Lacroix, C. Cottereaux, S. Meurisse, Patrick Mollat, F. Brebion, D. Comas, Christopher B. Little, Margaret M. Smith
Publikováno v:
Osteoarthritis and Cartilage. 30:291-301
Summary Objective A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a key enzyme in degradation of cartilage in osteoarthritis (OA). We report the pharmacological characterization of GLPG1972/S201086, a new, potent and sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3703c4b9781633c63762275b997650
https://doi.org/10.1016/j.joca.2021.08.012
https://doi.org/10.1016/j.joca.2021.08.012
Autor:
Stéphanie Lavazais, Manja Jargosch, Sonia Dupont, Frédéric Labéguère, Christel Menet, Catherine Jagerschmidt, Frenz Ohm, Laszlo Kupcsik, Isabelle Parent, Céline Cottereaux, Florence Marsais, Line Oste, An Van de Water, Thierry Christophe, Steve De Vos, Padraic Fallon, Felix Lauffer, Philippe Clément-Lacroix, Kilian Eyerich, Reginald Brys
Publikováno v:
Science Translational Medicine. 15
Innate immunity not only shapes the way epithelial barriers interpret environmental cues but also drives adaptive responses. Therefore, modulators of innate immune responses are expected to have high therapeutic potential across immune-mediated infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d1ddc3b64e21e46fda5864368a152e3
https://doi.org/10.1126/scitranslmed.abj3289
https://doi.org/10.1126/scitranslmed.abj3289
Autor:
Alain Monjardet, Thierry Christophe, Nicolas Triballeau, Helene Jary, Luke Jonathan Alvey, Romain Luc Marie Gosmini, Frédéric André De Ceuninck, Pierre Deprez, Robert Touitou, Roland Blanque, D. Amantini, Nele Vandervoort, Ellen van der Aar, Philip Leonard, F. Brebion, Patrick Mollat, Natacha Bienvenu, C. Cottereaux, I. Botez, Varin Marie Laurence Claire, Christophe Peixoto
Publikováno v:
Journal of Medicinal Chemistry. 64:2937-2952
There are currently no approved disease-modifying osteoarthritis (OA) drugs (DMOADs). The aggrecanase ADAMTS-5 is key in the degradation of human aggrecan (AGC), a component of cartilage. Therefore, ADAMTS-5 is a promising target for the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63e1d09bcd2c3ffc719892459e89ab3
https://doi.org/10.1021/acs.jmedchem.0c02008
https://doi.org/10.1021/acs.jmedchem.0c02008
Autor:
Graeme Milligan, Luke Jonathan Alvey, Annick Hagers, Thierry Christophe, Emanuelle Wakselman, Luc Nelles, Line Oste, Steve De Vos, Ann Vandevelde, Katja Conrath, Laurent Saniere, Stephen Robert Fletcher, Laura Jenkins, Sandrine Le Tallec, D. Merciris, Pierre Deprez, Roland Blanque, C. Cottereaux, Romain Luc Marie Gosmini, Ellen van der Aar, Cécile da Costa, Sonia Dupont, Thi Thu Trang Mai, Vanessa Quenehen, Labeguere Frederic Gilbert, Philippe Clément-Lacroix, Florilène Soulas, Reginald Brys, Gregory John Robert Newsome, Nele Vandervoort, Amynata Tirera
Publikováno v:
Journal of Medicinal Chemistry. 63:13526-13545
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8f803bd9662806c89d70fe1a829f85
https://doi.org/10.1021/acs.jmedchem.0c00272
https://doi.org/10.1021/acs.jmedchem.0c00272
Autor:
Nicolas Triballeau, Bertrand Heckmann, Nicolas Houvenaghel, Tanja Poljak, F. Marsais, Adeline Marie Elise Palisse, Emanuelle Wakselman, Mario Smehil, Mia Jans, Kathleen Sonck, Monica Borgonovi, Denis Bucher, Sandy El Bkassiny, Javier Blanc, Beatrice Coornaert, Thierry Christophe, Philippe Pujuguet, Vatroslav Letfus, M. Auberval, Lola Lecru, Laurent Saniere, Inge Duys, Reginald Brys, Line Oste, Brigitte Allart, Alex Jaunet, Maxim De Wachter, Catherine Jagerschmidt, Koen Karel Jansen, Oscar Mammoliti, Ludovic Waeckel, Giovanni Tricarico, Christel Jeanne Marie Menet, Renata Rupčić
Publikováno v:
Journal of medicinal chemistry. 64(19)
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease. Current treatments only slow down disease progression, making new therapeutic strategies compelling. Increasing evidence suggests that S1P2 antagonists could be effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045dde34db98ae7f215ad12e45f175db
https://pubmed.ncbi.nlm.nih.gov/34581584
https://pubmed.ncbi.nlm.nih.gov/34581584
Autor:
Thierry Christophe, Nicolas Houvenaghel, Philippe Clément-Lacroix, Reginald Brys, Line Oste, Inge Duys, Emanuelle Wakselman, Bertrand Heckmann, Caroline Joannesse, Alex Jaunet, Adeline Marie Elise Palisse, Brigitte Allart, Laurent Saniere, Mia Jans, Monica Borgonovi, Sandy El Bkassiny, Oscar Mammoliti, Beatrice Coornaert, Christel Jeanne Marie Menet, Kathleen Sonck
Publikováno v:
Journal of medicinal chemistry. 64(9)
Mounting evidence from the literature suggests that blocking S1P2 receptor (S1PR2) signaling could be effective for the treatment of idiopathic pulmonary fibrosis (IPF). However, only a few antagonists have been so far disclosed. A chemical enablemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf77a662664d4953efc380b9590624
https://pubmed.ncbi.nlm.nih.gov/33939425
https://pubmed.ncbi.nlm.nih.gov/33939425
Autor:
Thierry, Christophe
Le livre, consacré à la littérature en Thuringe au Moyen Âge, est l’œuvre d’un spécialiste, qui a déjà consacré plusieurs travaux à ce sujet, notamment une Geschichte der mittelalterlichen deutschen Literatur Thüringens en 2012. Comme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=openedition_::7687b356307c137aa61964cc414da0bd
http://journals.openedition.org/ccm/5169
http://journals.openedition.org/ccm/5169
