Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Thienorphine"'
Akademický článek
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Autor:
Ling-Lei Kong, Guo-Lin Shen, Zhi-Yuan Wang, Xiao-Mei Zhuang, Wei-Bin Xiao, Mei Yuan, Ze-Hui Gong, Hua Li
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G) unde
Externí odkaz:
https://doaj.org/article/23dd9e0dc695449cab63adec03644287
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 2, Iss 2, Pp 174-180 (2012)
Thienorphine (TNP) is a new partial opioid agonist currently developed as a promising drug candidate with the intended clinical indication for the treatment of opioid dependence. The pharmacokinetic profile and biliary excretion of TNP and its glucur
Externí odkaz:
https://doaj.org/article/49902e8116df4dc7adc0127f2c65cc6e
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
European Journal of Pharmacology. 789:144-151
Opioid analgesics are widely used in moderate to severe pain including renal colic. Morphine is believed to cause spasm of ureter and affect the bladder contractions. Thienorphine is a partial opioid agonist that is a good candidate for the treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59540f31c2b02a5994c46a52b91371c8
https://doi.org/10.1016/j.ejphar.2016.07.029
https://doi.org/10.1016/j.ejphar.2016.07.029
Publikováno v:
Brain Research. 1748:147083
Thienorphine hydrochloride is a new anti-relapse drug for opioid abusers that is currently in phase II clinical trial. In the present study, the antinociception, dependence, and signal transduction induced by thienorphine were examined. Thienorphine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f6c4873845202c8b4fb9a8bcc00355
https://doi.org/10.1016/j.brainres.2020.147083
https://doi.org/10.1016/j.brainres.2020.147083
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
European Journal of Pharmacology. 737:22-28
Opioid analgesics are widely believed to cause spasm of the bile duct sphincter and so impede bile flow. Thienorphine is a partial opioid agonist that is a good candidate for the treatment of opioid dependence; however, to date, no studies have repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0476f77ad02ffced545629d72bd1f78
https://doi.org/10.1016/j.ejphar.2014.04.044
https://doi.org/10.1016/j.ejphar.2014.04.044
Publikováno v:
Drug Delivery. 23:777-783
Poly (d,l-lactic-co-glycolide) nanoparticles (PLGA-NPs) have attracted considerable interest as new delivery vehicles for small molecules, with the potential to overcome issue such as poor drug solubility and cell permeability. However, their negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042a629aeb12d340e39e081acb33aaf1
https://doi.org/10.3109/10717544.2014.916765
https://doi.org/10.3109/10717544.2014.916765
Publikováno v:
Synapse. 67:779-785
Thienorphine is a new nonselective partial agonist of opioid receptors, which is currently under a Phase II clinical trial in China as a new treatment for opioid dependence. In this study, we compared the effect of thienorphine with morphine on long-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20fa2c15bc803cbdeb6c34e7618d9a07
https://doi.org/10.1002/syn.21682
https://doi.org/10.1002/syn.21682