Hepatocyte growth factor as a downstream mediator of vascular endothelial growth factor-dependent preservation of growth in the developing lung

Autor: Thiennu H. Vu, Steven H. Abman, Alexander Jordan Metoxen, Gregory J. Seedorf, Neil E. Markham, Robert Rock, Sharon L. Ryan

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 310:L1098-L1110

Impaired vascular endothelial growth factor (VEGF) signaling contributes to the pathogenesis of bronchopulmonary dysplasia (BPD). We hypothesized that the effects of VEGF on lung structure during development may be mediated through its downstream eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026bbd12fff8178af63a50a075dbf9b3
https://doi.org/10.1152/ajplung.00423.2015

Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity

Autor: Peter Colosi, Cameron M. McDougall, Dingquan Zou, Hua Su, Zhijian Wu, Wan Zhu, Michael T. Lawton, Lei Zhan, Zhengda Sun, Thiennu H. Vu, John Forsayeth, Fanxia Shen, Abraham Scaria, Lei Mao, Rui Zhang, Jeffrey Nelson, Shuai Kang

Publikováno v: Zhu, W; Shen, F; Mao, L; Zhan, L; Kang, S; Sun, Z; et al.(2017). Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity. Stroke, 48(5), 1420-1423. doi: 10.1161/STROKEAHA.116.015713. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6wd4n6t1
Stroke, vol 48, iss 5

Background and Purpose— Brain arteriovenous malformation (bAVM) is an important risk factor for intracranial hemorrhage. Current therapies are associated with high morbidities. Excessive vascular endothelial growth factor has been implicated in bAV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dd974a77eb24988d1a567d8d9c6375
http://www.escholarship.org/uc/item/6wd4n6t1

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice

Autor: Kevin Tan, Walter Lorizio, Alexis N. Brumwell, Jonathan P. Alexander, Xiaopeng Li, Thiennu H. Vu, Arnoud Sonnenberg, Harold A. Chapman, Ying Wei

Publikováno v: Journal of Clinical Investigation. 121:2855-2862

Laminins and their integrin receptors are implicated in epithelial cell differentiation and progenitor cell maintenance. We report here that a previously unrecognized subpopulation of mouse alveolar epithelial cells (AECs) expressing the laminin rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e56ae045bff6c48d4451a39a39b3a2d
https://doi.org/10.1172/jci57673

Identification of P311 as a Potential Gene Regulating Alveolar Generation

Autor: James K. Leung, Farrah Kheradmand, Hiroaki Yamamoto, Sangeeta Goswami, Thiennu H. Vu, Liqing Zhao

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 35:48-54

Smoking-related destructive lung diseases such as chronic obstructive pulmonary disease (COPD) and emphysema are a major cause of morbidity and mortality worldwide. The immediate cause of emphysema is the obliteration of alveoli that are key function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe9ea9cecedc5a4ab0eb4538a72e863
https://doi.org/10.1165/rcmb.2005-0475oc

Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature

Autor: Thiennu H. Vu, Napoleone Ferrara, Ke Wang, Liqing Zhao

Publikováno v: Mechanisms of Development. 122(7-8):877-886

The vasculature forms an intrinsic functional component of the lung and its development must be tightly regulated and coordinated with lung epithelial morphogenesis. Vascular endothelial growth factor (VEGF) and its receptors are highly expressed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2864c3c445fe998bc138eb023a357c02