Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Thien-Fah Mah"'
Autor:
Kanchi Baijal, Iryna Abramchuk, Carmen M Herrera, Thien-Fah Mah, M Stephen Trent, Mathieu Lavallée-Adam, Michael Downey
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002558 (2024)
Polyphosphates (polyP) are chains of inorganic phosphates that can reach over 1,000 residues in length. In Escherichia coli, polyP is produced by the polyP kinase (PPK) and is thought to play a protective role during the response to cellular stress.
Externí odkaz:
https://doaj.org/article/73e0db87c2774996a791644695328b0a
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Pseudomonas aeruginosa thrives in the airways of individuals with cystic fibrosis, in part by forming robust biofilms that are resistant to immune clearance or antibiotic treatment. In the cystic fibrosis lung, the thickened mucus layers create an ox
Externí odkaz:
https://doaj.org/article/eba989a5e2e64a8ba5b6a1ea6c2f005d
Autor:
Irene Guzmán-Soto, Christopher McTiernan, Mayte Gonzalez-Gomez, Alex Ross, Keshav Gupta, Erik J. Suuronen, Thien-Fah Mah, May Griffith, Emilio I. Alarcon
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102443- (2021)
Summary: Biofilm formation in living organisms is associated to tissue and implant infections, and it has also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm development and being able to mimic such processes is
Externí odkaz:
https://doaj.org/article/8e6ad75c21d640fbbae938df6773dae8
Publikováno v:
mSphere, Vol 4, Iss 2 (2019)
ABSTRACT The two-component system TctD-TctE is important for regulating the uptake of tricarboxylic acids in Pseudomonas aeruginosa. TctD-TctE accomplishes this through derepression of the gene opdH, which encodes a tricarboxylic acid-specific porin.
Externí odkaz:
https://doaj.org/article/4219bd99b4384b2e9bdaf0a40ed5303b
Publikováno v:
Heliyon, Vol 4, Iss 12, Pp e01067- (2018)
In living organisms, biofilms are defined as complex communities of bacteria residing within an exopolysaccharide matrix that adheres to a surface. In the clinic, they are typically the cause of chronic, nosocomial, and medical device-related infecti
Externí odkaz:
https://doaj.org/article/5ceb146c95094b14b73381385e768733
Autor:
Patrick K Taylor, Antonius T M Van Kessel, Antonio Colavita, Robert E W Hancock, Thien-Fah Mah
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182582 (2017)
The regulation of biofilm development requires multiple mechanisms and pathways, but it is not fully understood how these are integrated. Small RNA post-transcriptional regulators are a strong candidate as a regulatory mechanism of biofilm formation.
Externí odkaz:
https://doaj.org/article/61fd25f64b264ef88ed5ac24af399a9b
Autor:
Li Zhang, Meredith Fritsch, Lisa Hammond, Ryan Landreville, Cristina Slatculescu, Antonio Colavita, Thien-Fah Mah
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61625 (2013)
Pseudomonas aeruginosa is a key opportunistic pathogen characterized by its biofilm formation ability and high-level multiple antibiotic resistance. By screening a library of random transposon insertion mutants with an increased biofilm-specifc antib
Externí odkaz:
https://doaj.org/article/3f64d85e5ed2469e834dd78d598fdf68
Publikováno v:
Frontiers in Microbiology; 2023, p1-11, 11p
Autor:
André R. Paquette, Sterling R. Payne, Geoffrey A. McKay, Jordan T. Brazeau-Henrie, Micheal G. Darnowski, Anitha Kammili, Federico Bernal, Thien-Fah Mah, Samantha Gruenheid, Dao Nguyen, Christopher N. Boddy
Publikováno v:
RSC Medicinal Chemistry. 13:445-455
Optimized RpoN-based stapled peptides selectively bind promoter DNA sequence and inhibit virulence of Pseudomonas aeruginosa in an in vivo model.
Autor:
André R, Paquette, Sterling R, Payne, Geoffrey A, McKay, Jordan T, Brazeau-Henrie, Micheal G, Darnowski, Anitha, Kammili, Federico, Bernal, Thien-Fah, Mah, Samantha, Gruenheid, Dao, Nguyen, Christopher N, Boddy
Publikováno v:
RSC Med Chem
Stapled peptides have the ability to mimic α-helices involved in protein binding and have proved to be effective pharmacological agents for disrupting protein–protein interactions. DNA-binding proteins such as transcription factors bind their cogn