Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thibaut Imberdis"'
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007283 (2018)
Synaptic degeneration is one of the earliest pathological correlates of prion disease, and it is a major determinant of the progression of clinical symptoms. However, the cellular and molecular mechanisms underlying prion synaptotoxicity are poorly u
Externí odkaz:
https://doaj.org/article/c04bb2bb643346d8aaf7fbcaa772cf8c
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005623 (2016)
Synaptic pathology is an early feature of prion as well as other neurodegenerative diseases. Although the self-templating process by which prions propagate is well established, the mechanisms by which prions cause synaptotoxicity are poorly understoo
Externí odkaz:
https://doaj.org/article/1ba9a8f0a2664876bbd25b21def6beee
Autor:
Sylvaine Huc-Brandt, Nelson Hieu, Thibaut Imberdis, Nicolas Cubedo, Michelle Silhol, Patricia L A Leighton, Thomas Domaschke, W Ted Allison, Véronique Perrier, Mireille Rossel
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113331 (2014)
Prion protein is involved in severe neurodegenerative disorders but its physiological role is still in debate due to an absence of major developmental defects in knockout mice. Previous reports in zebrafish indicate that the two prion genes, PrP1 and
Externí odkaz:
https://doaj.org/article/e2cfb2daf3fc420bbc20ab6098895275
Publikováno v:
International Journal of Cell Biology, Vol 2013 (2013)
Prion diseases are fatal neurodegenerative sporadic, inherited, or acquired disorders. In humans, Creutzfeldt-Jakob disease is the most studied prion disease. In animals, the most frequent prion diseases are scrapie in sheep and goat, bovine spongifo
Externí odkaz:
https://doaj.org/article/b3f266be79e4473484c753529ff5baaf
Publikováno v:
Journal of Neurochemistry. 165:246-258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7df38e15c068c9974f48af647fbc510c
https://doi.org/10.1111/jnc.15763
https://doi.org/10.1111/jnc.15763
Autor:
Arati Tripathi, Heba Alnakhala, Elizabeth Terry-Kantor, Andrew Newman, Lei Liu, Thibaut Imberdis, Saranna Fanning, Silke Nuber, Nagendran Ramalingam, Dennis Selkoe, Ulf Dettmer
Publikováno v:
J Neurosci
α-Synuclein (αS) plays a key role in Parkinson's disease. Although Parkinson's disease is typically “sporadic,” inherited αS missense mutations provide crucial insights into molecular mechanisms. Here, we examine two clinical mutants, E46K and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0403987c65b329da0b220e75feb6c3
https://doi.org/10.1523/jneurosci.1881-21.2022
https://doi.org/10.1523/jneurosci.1881-21.2022
Autor:
Andrew J. Newman, Thibaut Imberdis, Nagendran Ramalingam, Dennis J. Selkoe, Saranna Fanning, Tae-Eun Kim, Ulf Dettmer, Arati Tripathi, Lisa Brontesi
Publikováno v:
Human Molecular Genetics
α-Synuclein (αS) has been well-documented to play a role in human synucleinopathies such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). First, the lesions found in PD/DLB brains—Lewy bodies and Lewy neurites—are rich in aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b68a131888ea5880050feaa42030206
https://doi.org/10.1093/hmg/ddab188
https://doi.org/10.1093/hmg/ddab188
Autor:
Xiaoping Hronowski, Haley Cirka, Molly M Rajsombath, Silke Nuber, Kevin J. Hodgetts, Christian P. Müller, Thibaut Imberdis, Andreas Weihofen, Ulf Dettmer, Dennis J. Selkoe, Saranna Fanning, Jürgen Winkler, Alice Y Nam, Liubov S. Kalinichenko, Vera Lambrecht, Junmin Wang
Publikováno v:
Annals of Neurology
Objective Parkinson disease (PD) has useful symptomatic treatments that do not slow the neurodegenerative process, and no significant disease-modifying treatments are approved. A key therapeutic target in PD is α-synuclein (αS), which is both genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf767deba263a4ec1a59f5fdd8c5bc9
https://doi.org/10.1002/ana.25920
https://doi.org/10.1002/ana.25920
Autor:
Tracy L. Young-Pearse, Ulf Dettmer, Thibaut Imberdis, Elizabeth Terry-Kantor, Dennis J. Selkoe, Oren A. Levy, Tae-Eun Kim, Saranna Fanning, Gary P.H. Ho, Georgia L. Stirtz, Joseph Negri, Nagendran Ramalingam
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Misfolding and accumulation of the protein α-synuclein (αS) inside nerve cells characterize Parkinson’s disease (PD) and related brain diseases, for which no disease-modifying therapies exist. Robust cell models are needed that recap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4501e0548e0147d5434121663847b8e
https://doi.org/10.1073/pnas.1903216116
https://doi.org/10.1073/pnas.1903216116
Autor:
Elizabeth Terry-Kantor, Zachary M LaVoie, Thibaut Imberdis, Arati Tripathi, Dennis J. Selkoe, Gary P.H. Ho, Ulf Dettmer, Saranna Fanning, Nagendran Ramalingam
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 15
International Journal of Molecular Sciences, Vol 21, Iss 5193, p 5193 (2020)
Volume 21
Issue 15
International Journal of Molecular Sciences, Vol 21, Iss 5193, p 5193 (2020)
Genetic and biochemical evidence attributes neuronal loss in Parkinson&rsquo
s disease (PD) and related brain diseases to dyshomeostasis of the 14 kDa protein &alpha
synuclein (&alpha
S). There is no consensus on how &alpha
S exer
s disease (PD) and related brain diseases to dyshomeostasis of the 14 kDa protein &alpha
synuclein (&alpha
S). There is no consensus on how &alpha
S exer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090d04563685bf18328d9dbab9f98eb4