Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration

Autor: Thibaut Desgeorges, Eva Galle, Jing Zhang, Ferdinand von Meyenn, Katrien De Bock

Publikováno v: Molecular Metabolism, Vol 83, Iss , Pp 101923- (2024)

Objectives: We have previously shown that lactate is an essential metabolite for macrophage polarisation during ischemia-induced muscle regeneration. Recent in vitro work has implicated histone lactylation, a direct derivative of lactate, in macropha

Externí odkaz: https://doaj.org/article/287e519043c34a03a1f37341da88e588

Open-CSAM, a new tool for semi-automated analysis of myofiber cross-sectional area in regenerating adult skeletal muscle

Autor: Thibaut Desgeorges, Sophie Liot, Solene Lyon, Jessica Bouvière, Alix Kemmel, Aurélie Trignol, David Rousseau, Bruno Chapuis, Julien Gondin, Rémi Mounier, Bénédicte Chazaud, Gaëtan Juban

Publikováno v: Skeletal Muscle, Vol 9, Iss 1, Pp 1-12 (2019)

Abstract Adult skeletal muscle is capable of complete regeneration after an acute injury. The main parameter studied to assess muscle regeneration efficacy is the cross-sectional area (CSA) of the myofibers as myofiber size correlates with muscle for

Externí odkaz: https://doaj.org/article/af468bb1cfe74c36946bbc447c839939

Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids

Autor: Giorgio Caratti, Thibaut Desgeorges, Gaëtan Juban, Ulrich Stifel, Aurélie Fessard, Mascha Koenen, Bozhena Caratti, Marine Théret, Carsten Skurk, Bénédicte Chazaud, Jan P Tuckermann, Rémi Mounier

Macrophages are key cells after tissue damage since they mediate both acute inflammatory phase and regenerative inflammation by shifting from pro-inflammatory to restorative cells. Glucocorticoids (GCs) are the most potent anti-inflammatory hormone i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe217c6af0dbf216f31decfdc796710

Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation

Autor: Juliana E Toller-Kawahisa, Marine Theret, Julien Gondin, Rémi Mounier, Bénédicte Chazaud, Simon McArthur, Thibaut Desgeorges, Chris P. M. Reutelingsperger, Thomas Gobbetti, Mauro Perretti, Gaëtan Juban

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2020, 130, pp.1156-1167. ⟨10.1172/jci124635⟩
Journal of Clinical Investigation, 130(3), 1156-1167. American Society for Clinical Investigation
The Journal of Clinical Investigation

International audience; Understanding the circuits that promote an efficient resolution of inflammation is crucial to deciphering the molecular and cellular processes required to promote tissue repair. Macrophages play a central role in the regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a01610c81a2307258c6a5eac4b78e7d
https://doi.org/10.1172/jci124635

AMPKα1 is essential for Glucocorticoid Receptor triggered anti-inflammatory macrophage activation

Autor: Bénédicte Chazaud, Gaëtan Juban, Mascha Koenen, Giorgio Caratti, Jan Tuckermann, Thibaut Desgeorges, Bozhena Kozak, Marine Theret, Rémi Mounier

SummaryMacrophages are key immune cells which mediate both the acute inflammatory phase and the repair phase after tissue damage. Macrophages switch from pro-inflammatory to anti-inflammatory cells that sustain repair and return to tissue homeostasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba96899a1b67a70db95acf78aaa4dbef
https://doi.org/10.1101/2020.01.02.892836