Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thibaut De Smedt"'
Autor:
Nathalie Busso, Mahir Karababa, Massimo Nobile, Aline Rolaz, Frédéric Van Gool, Mara Galli, Oberdan Leo, Alexander So, Thibaut De Smedt
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2267 (2008)
Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting enzyme in the salvage pathway of NAD biosynthesis from nicotinamide. Since its expression is upregulated during inflammation, NAMPT represents a novel clinic
Externí odkaz:
https://doaj.org/article/47341f4c91b14572a6d75de2584587a5
Autor:
Nicolás Gonzalo Núñez, Roger Geiger, Florian Gobet, Mark Conti, Isabelle Dunand-Sauthier, Walter Reith, Kerstin Hahn, Sylvain Lemeille, Alessandra Piersigilli, Stéphanie Hugues, Adrià-Arnau Martí i Líndez, Thibaut De Smedt, Burkhard Becher, J. Thomas Hannich, Howard Riezman
Publikováno v:
JCI Insight, Vol. 4, No 24 (2019)
As sufficient extracellular arginine is crucial for T cell function, depletion of extracellular arginine by elevated arginase 1 (Arg1) activity has emerged as a hallmark immunosuppressive mechanism. However, the potential cell-autonomous roles of arg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142393d6a875bcb7e19b979eac87d1fe
https://europepmc.org/articles/PMC6975264/
https://europepmc.org/articles/PMC6975264/
Autor:
Véronique Kruys, Cyril Gueydan, Frédéric Van Gool, Thibaut De Smedt, Raul Mostoslavsky, Oberdan Leo, Mara Galli, Pierre Paul Prevot, Frederick W. Alt, Antonio Bedalov
Publikováno v:
Nature Medicine. 15:206-210
Tumor necrosis factor (TNF) synthesis is known to play a major part in numerous inflammatory disorders, and multiple transcriptional and post-transcriptional regulatory mechanisms have therefore evolved to dampen the production of this key proinflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6feda68ce9637b82016aa2e17d6c2249
https://doi.org/10.1038/nm.1906
https://doi.org/10.1038/nm.1906
Autor:
Menno van Nimwegen, Mirjam Kool, Bart N. Lambrecht, Jürg Tschopp, Aline Rolaz, Hamida Hammad, Thibaut De Smedt, Virginie Pétrilli, Rosa Castillo, Ingrid M. Bergen
Publikováno v:
Scopus-Elsevier
Adjuvants are vaccine additives that stimulate the immune system without having any specific antigenic effect of itself. In this study we show that alum adjuvant induces the release of IL-1β from macrophages and dendritic cells and that this is abro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a776af174ec3a74c299a33a02fb0a089
https://doi.org/10.4049/jimmunol.181.6.3755
https://doi.org/10.4049/jimmunol.181.6.3755
Autor:
Steven F. Ziegler, Martin E Dahl, Daniel J. Campbell, Baohua Zhou, David B. Lewis, Michael R. Comeau, H. Denny Liggitt, Theingi Aye, Thibaut De Smedt, Dora Gyarmati
Publikováno v:
Nature Immunology. 6:1047-1053
The cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor-deficient mice had consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c942e6dd0f75abfe301e8034b2d42871
https://doi.org/10.1038/ni1247
https://doi.org/10.1038/ni1247
Autor:
Brad Greenfield, Pierre Brawand, Charles R. Maliszewski, Thibaut De Smedt, David Fitzpatrick, Kenneth Brasel
Publikováno v:
The Journal of Immunology. 169:6711-6719
The putative counterparts of human plasmacytoid pre-dendritic cells (pDCs) have been described in vivo in mouse models and very recently in an in vitro culture system. In this study, we report that large numbers of bone marrow-derived murine CD11c+B2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffa7b957b6f0dadca0ebf0145620f6b
https://doi.org/10.4049/jimmunol.169.12.6711
https://doi.org/10.4049/jimmunol.169.12.6711
Autor:
Thibaut De Smedt, Eric A. Butz, Peter Robert Baum, William C. Fanslow, Charles R. Maliszewski, Jeffrey S. Smith
Publikováno v:
The Journal of Immunology. 168:661-670
Dendritic cells (DCs) are bone marrow-derived APCs that display unique properties aimed at stimulating naive T cells. Several members of the TNF/TNFR families have been implicated in T cell functions. In this study, we examined the role that Ox40 cos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb78466bb10f09303164a2a48565203
https://doi.org/10.4049/jimmunol.168.2.661
https://doi.org/10.4049/jimmunol.168.2.661
Autor:
Jeffrey S. Smith, Muriel Moser, Bernard Pajak, Thibaut De Smedt, Roberto Maldonado-López, Charles R. Maliszewski, Eric A. Butz
Publikováno v:
Journal of Leukocyte Biology. 69:951-958
Dendritic cells (DCs) are essential for the priming of immune responses. This antigen-presenting function of DCs develops in sequence in a process called maturation, during which they become potent sensitizers of naïve T cells but reduce their abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06d8c85e05ac231e7f7173e4c5171c9
https://doi.org/10.1189/jlb.69.6.951
https://doi.org/10.1189/jlb.69.6.951
Publikováno v:
Blood. 96:3029-3039
Murine dendritic cells (DCs) can be classified into at least 2 subsets, “myeloid-related” (CD11bbright, CD8α−) and “lymphoid-related” (CD11bdull, CD8α+), but the absolute relationship between the 2 remains unclear. Methods of generating D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa29bf850e2e16567946ad3855c58ab
https://doi.org/10.1182/blood.v96.9.3029.h8003029_3029_3039
https://doi.org/10.1182/blood.v96.9.3029.h8003029_3029_3039
Autor:
Muriel Moser, Véronique Moulin, Emmanuel Briend, Georgette Vansanten, Roberto Maldonado-López, Bernard Pajak, Thibaut De Smedt, Oberdan Leo, Carl De Trez, Jacques Urbain
Publikováno v:
Journal of Clinical Pathology. 53:518-524
Aims—To describe a new fixation and embedding method for tissue samples, immunohistowax processing, which preserves both morphology and antigen immunoreactivity, and to use this technique to investigate the role of dendritic cells in the immune res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025d996d443acdef47aa3c080d21a25d
https://doi.org/10.1136/jcp.53.7.518
https://doi.org/10.1136/jcp.53.7.518