Cortical Circuit Dysfunction as a Potential Driver of Amyotrophic Lateral Sclerosis

Autor: Aurore Brunet, Geoffrey Stuart-Lopez, Thibaut Burg, Jelena Scekic-Zahirovic, Caroline Rouaux

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects selected cortical and spinal neuronal populations, leading to progressive paralysis and death. A growing body of evidences suggests that the disease may origi

Externí odkaz: https://doaj.org/article/8a1ed8a5b50042f1995609ace847b0c7

Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis

Autor: Matthieu Moisse, Philip Van Damme, Thibaut Burg, Ludo Van Den Bosch, Elisabeth Rossaert

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11224, p 11224 (2021)
Volume 22
Issue 20

Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disorder of the motor system. While the etiology is still incompletely understood, defects in metabolism act as a major contributor to the disease progression. Recently,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4740f24a560440596c98626d3697036
https://lirias.kuleuven.be/handle/123456789/682942

Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanism

Autor: Jelena, Scekic-Zahirovic, Mathieu, Fischer, Geoffrey, Stuart-Lopez, Thibaut, Burg, Johan, Gilet, Sylvie, Dirrig-Grosch, Christine, Marques, Marie-Christine, Birling, Pascal, Kessler, Caroline, Rouaux

Publikováno v: Progress in neurobiology. 200

Amyotrophic lateral sclerosis (ALS) arises from the combined degeneration of motor neurons (MN) and corticospinal neurons (CSN). Recent clinical and pathological studies suggest that ALS might start in the motor cortex and spread along the corticofug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0aa40d398c2f738929ee1469394d26c
https://pubmed.ncbi.nlm.nih.gov/33309802

Absence of Subcerebral Projection Neurons Is Beneficial in a Mouse Model of Amyotrophic Lateral Sclerosis

Autor: Thibaut Burg, Charlotte Bichara, Jelena Scekic‐Zahirovic, Mathieu Fischer, Geoffrey Stuart‐Lopez, Aurore Brunet, François Lefebvre, Matilde Cordero‐Erausquin, Caroline Rouaux

Publikováno v: Annals of Neurology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::03a527a9759c1a196b26a03a976a17c0

Absence of subcerebral projection neurons delays disease onset and extends survival in a mouse model of ALS

Autor: Mathieu Fischer, Matilde Cordero-Erausquin, Caroline Rouaux, Geoffrey Stuart-Lopez, François Lefebvre, Jelena Scekic-Zahirovic, Thibaut Burg, Charlotte Bichara

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease of adulthood that affects voluntary motricity and rapidly leads to full paralysis and death. ALS arises from the combined degeneration of motoneurons in the spinal cord and brai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02577a749dc0432dd419180f3ca250d