Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Thibault Hirsch"'
Autor:
Thibault Hirsch, Damien Neyens, Céline Duhamel, Alexandre Bayard, Christophe Vanhaver, Mathieu Luyckx, Francisco Sala de Oyanguren, Claude Wildmann, Nicolas Dauguet, Jean-Luc Squifflet, Virginie Montiel, Mélanie Deschamps, Pierre van der Bruggen
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114401- (2024)
Summary: Human CD8 tumor-infiltrating lymphocytes (TILs) with impaired effector functions and PD-1 expression are categorized as exhausted. However, the exhaustion-like features reported in TILs might stem from their activation rather than the conseq
Externí odkaz:
https://doaj.org/article/0f085d4caac14811beacbcd7a9577525
Autor:
Damien Neyens, Thibault Hirsch, Achraqat Abdel Aziz Issa Abdel Hadi, Nicolas Dauguet, Christophe Vanhaver, Alexandre Bayard, Claude Wildmann, Mathieu Luyckx, Jean-Luc Squifflet, Quentin D’Hondt, Céline Duhamel, Antoine Huaux, Virginie Montiel, Mélanie Dechamps, Pierre van der Bruggen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells. However, information on human HELIOS+ CD8 T cells is limited and
Externí odkaz:
https://doaj.org/article/1b8bb38eba084558be37214e1573ea67
Autor:
Henri-François Renard, François Tyckaert, Cristina Lo Giudice, Thibault Hirsch, Cesar Augusto Valades-Cruz, Camille Lemaigre, Massiullah Shafaq-Zadah, Christian Wunder, Ruddy Wattiez, Ludger Johannes, Pierre van der Bruggen, David Alsteens, Pierre Morsomme
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
How and which cell surface molecules are taken up by clathrin-independent endocytosis is an ongoing area of research. Here, the authors show that the tumor marker CD166 is a clathrin-independent cargo that is taken up by endophilin-A3 and galectin-8,
Externí odkaz:
https://doaj.org/article/5ff27bc5c991414daddf2ddab6903674
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Most tumours are poorly infiltrated by T cells. Here the authors show that galectin-3 secreted by tumours binds both glycosylated IFNγ and glycoproteins of the tumour extracellular matrix, thus avoiding IFNγ diffusion and the formation of an IFNγ-
Externí odkaz:
https://doaj.org/article/ae4938525c0b414ebd58383ae6a1f724
Autor:
Pierre van der Bruggen, Camille Lemaigre, Cesar Augusto Valades-Cruz, Henri-François Renard, François Tyckaert, Ludger Johannes, Ruddy Wattiez, Cristina Lo Giudice, Pierre Morsomme, David Alsteens, Massiullah Shafaq-Zadah, Christian Wunder, Thibault Hirsch
Publikováno v:
Nature Communications, Vol. 11, no.1, p. 1457 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, 2020, 11 (1), pp.1457. ⟨10.1038/s41467-020-15303-y⟩
Nature Communications, Vol. 11, no. 1457, p. 1-13 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1457. ⟨10.1038/s41467-020-15303-y⟩
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, 2020, 11 (1), pp.1457. ⟨10.1038/s41467-020-15303-y⟩
Nature Communications, Vol. 11, no. 1457, p. 1-13 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1457. ⟨10.1038/s41467-020-15303-y⟩
While several clathrin-independent endocytic processes have been described so far, their biological relevance often remains elusive, especially in pathophysiological contexts such as cancer. In this study, we find that the tumor marker CD166/ALCAM (A